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| 1 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 2 | NLRP3炎症小体对急性胰腺炎小鼠全身炎症反应及代偿性抗炎反应综合征的调节作用显示文摘【据《Gastroenterology》2019年10月报道】题:NLRP3炎症小体对急性胰腺炎小鼠全身炎症反应及代偿性抗炎反应综合征的调节作用(作者Sendler M等)胰腺炎开始时主要是无菌的局部炎症,其引起全身性炎症反应综合征(SIRS),然后是代偿性抗炎反应综合征(CARS)。来自德国格赖夫斯瓦尔德大学的Sendler等通过研究探讨了小鼠和人类血清中该过程的机制。 | 李德钊 郭晓林 SENDLER M van den BRANDT C GLAUBITZ J | 2020 | 临床肝胆病杂志2020，36，3： | 24 |
| 3 | IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treat- ment of Cancer Brain Tumor Group显示文摘 | van den Bent M J Dubbink HJ Marie Y Brandes AA Taphoorn MJ Wesseling P Frenay M Tijssen CC Lacombe D ldbaih A van Marion R Kros JM Dinjens WN Gorlia T. Sanson M. | 2010 | 中国神经肿瘤杂志2010，8，1： | 22 |
| 4 | 大别山双河和碧溪岭超高压变质岩流体包裹体研究显示文摘对大别山双河和碧溪岭含柯石英榴辉岩和硬玉石英岩进行了详细的流体包裹体研究。根据流体包裹体的成分和盐度的不同 ,可以划分出至少五种类型不同的气液包裹体 :( 1) N2 包裹体 ;( 2 )高盐度流体包裹体 ;( 3) CO2 包裹体 ;( 4) CO2 -H2 O包裹体 ;( 5 )低盐度流体包裹体。N2 包裹体仅见于含柯石英榴辉岩 ,而高盐度流体包裹体则几乎存在于所有的榴辉岩和硬玉石英岩中。 CO2 包裹体沿榴辉岩中微剪切带分布 ,或存在于强变形的硬玉石英岩中 ,而低盐度流体包裹体分布较为局限。N2 和高盐度流体被认为是超高压变质作用平衡的产物 ,来源于变质前的古孔隙流体。而且榴辉岩中含有一系列盐度不同的流体显微域 ,其大小与矿物颗粒相当。在板块折返过程中 ,包裹体中流体可能发生迁移 ,但是不会超出寄主晶体的范围。CO2流体明显是外来的 ,可能来自共生大理岩或含碳酸盐的变质沉积岩。这与菱镁矿和柯石英等共生组合所指示的进变质过程中大理岩不存在脱碳反应的结论相一致。而低盐度流体则可能系顶峰变质矿物分解而成 。 | 傅斌 肖益林 J L R Touret A M Van den Kerkhof JHoefs 郑永飞 | 2000 | 岩石学报2000，16，1： | 14 |
| 5 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 6 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 7 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 8 | Development of ^(18)F-labeled radiotracers for neuroreceptor imaging with positron emission tomography显示文摘Positron emission tomography(PET)is an in vivo molecular imaging tool which is widely used in nuclear medicine for early diagnosis and treatment follow-up of many brain diseases.PET uses biomolecules as probes which are labeled with radionuclides of short half-lives,synthesized prior to the imaging studies.These probes are called radiotracers.Fluorine-18 is a radionuclide routinely used in the radiolabeling of neuroreceptor ligands for PET because of its favorable half-life of 109.8 min.The delivery of such radiotracers into the brain provides images of transport,metabolic,and neurotransmission processes on the molecular level.After a short introduction into the principles of PET,this review mainly focuses on the strategy of radiotracer development bridging from basic science to biomedical application.Successful radiotracer design as described here provides molecular probes which not only are useful for imaging of human brain diseases,but also allow molecular neuroreceptor imaging studies in various small-animal models of disease,including geneticallyengineered animals.Furthermore,they provide a powerful tool for in vivo pharmacology during the process of pre-clinical drug development to identify new drug targets,to investigate pathophysiology,to discover potential drug candidates,and to evaluate the pharmacokinetics and pharmacodynamics of drugs in vivo. | Peter Brust Jrg van den Hoff Jrg Steinbach | 2014 | Neuroscience Bulletin2014，30，5： | 3 |
| 9 | Meeting report:a hard look at the state of enamel research显示文摘The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines(ENAMEL) Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National Institute of Dental and Craniofacial Research(NIDCR). Discussion topics included model organisms, stem cells/cell lines, and tissues/3 D cell culture/organoids. Scientists from a number of disciplines,representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field. | ophir d klein olivier duverger wendy shaw rodrigo s lacruz derk joester janet moradian-oldak megan k pugach j timothy wright sarah e millar ashok b kulkarni john d bartlett thomas gh diekwisch pamela den besten james p simmer | 2017 | International Journal of Oral Science2017，9，4： | 3 |
| 10 | Medical image matching-a review with classification 显示文摘 | VAN DEN ELSEN P A POL E J D VIERGEVER M A | 1993 | IEEE Eng in Med & Biol1993，12，1： | 2 |
| 11 | Efficiency estimation from cobb-douglas production functions with composed error显示文摘 | Meeusen W & J van den Broeck | 1977 | International Economic Review1977，18，2： | 2 |
| 12 | Effect of 1,2-propanediol and dimethylsulphoxide on the meiotic spindle of the mouse oocytes显示文摘 | Van der Elst J van den Abbeel E Jacobs R | 1988 | Hum Reprod1988，3，： | 2 |
| 13 | Submicron and ultrafine grained hardmetals for microdrills and metal cutting inserts显示文摘 | G Gille B Szesny K Dreyer H van den Berg J Schmidt T Gestrich G Leitner | 2002 | International Journal of Refractory Metals and Hard Materials2002，，1： | 2 |
| 14 | Deep drawing simulations of Tailored Blanks and experimental verification 显示文摘 | MEINDERS T VAN DEN BERG A HUETINK J | 2000 | Journal of Materials Processing Technology2000，103，： | 2 |
| 15 | Can deterministic chaos create order in fluidized bed scale up 显示文摘 | van den Bleek C M Schouten J C | 1993 | Chem Eng Sci1993，48，13： | 2 |
| 16 | Argon plasma coagulation in flexible gastrointestinal endoscopy: pilot experiences 显示文摘 | Wahab PJ Mulder C J Den Hattog G | 1997 | Endoscopy1997，29，3： | 2 |
| 17 | Stability of oriented Silicalite-1 films in view of zeolite membrane preparation 显示文摘 | Den Exter M J Van Bekkum H Rijn C J M | 1997 | Zeolites1997，19，： | 1 |
| 18 | Site of triggering of the accommodation reflex in man显示文摘 | Van den Berghe PD Vos R Janssens J | 2000 | Gastroenterology2000，114，： | 1 |
| 19 | The carboxyl-terminal part of the putative Berne virus polymerase is expressed by ribosomal frameshifting and contains sequence motifs which indicate that toro- and eoronaviruses are evolutionarily related 显示文摘 | Snijder E J den Boon J A Bredenbeek P J | 1990 | Nucleic Acids Res1990，18，： | 1 |
| 20 | Hamilton cycles and eigenvalues of graphs显示文摘 | Van Den Heuvel J | 1995 | Linear Algebra and its Applications1995，，： | 1 |
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