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| 1 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 2 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 3 | Gelatin degradation assay reveals MMP-9 inhibitors and function of O-glycosylated domain显示文摘AIM: To establish a novel, sensitive and high-throughput gelatinolytic assay to define new inhibitors and compare domain deletion mutants of gelatinase B/matrix metalloproteinase (MMP)-9. METHODS: Fluorogenic Dye-quenched (DQ)TM-gelatin was used as a substrate and biochemical parameters (substrate and enzyme concentrations, DMSO solvent concentrations) were optimized to establish a highthroughput assay system. Various small-sized libraries (ChemDiv, InterBioScreen and ChemBridge) of hetero-cyclic, drug-like substances were tested and compared with prototypic inhibitors. RESULTS: First, we designed a test system with gelatin as a natural substrate. Second, the assay was validated by selecting a novel pyrimidine-2,4,6-trione (barbitu- rate) inhibitor. Third, and in line with present structural data on collagenolysis, it was found that deletion of the O-glycosylated region significantly decreased gelatinolytic activity (kcat/kM ± 40% less than full-length MMP-9). CONCLUSION: The DQTM-gelatin assay is useful in high-throughput drug screening and exosite targeting. We demonstrate that flexibility between the catalytic and hemopexin domain is functionally critical for gelatinolysis. | Jennifer Vandooren Nathalie Geurts Erik Martens Philippe E Van den Steen Steven De Jonghe Piet Herdewijn Ghislain Opdenakker | 2011 | World Journal of Biological Chemistry2011，2，1： | 3 |
| 4 | Meeting report:a hard look at the state of enamel research显示文摘The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines(ENAMEL) Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National Institute of Dental and Craniofacial Research(NIDCR). Discussion topics included model organisms, stem cells/cell lines, and tissues/3 D cell culture/organoids. Scientists from a number of disciplines,representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field. | ophir d klein olivier duverger wendy shaw rodrigo s lacruz derk joester janet moradian-oldak megan k pugach j timothy wright sarah e millar ashok b kulkarni john d bartlett thomas gh diekwisch pamela den besten james p simmer | 2017 | International Journal of Oral Science2017，9，4： | 3 |
| 5 | Effect of a loading dose regimen of three infusions of chimeric monoclonal antibody to tumour necrosis factor alpha (infliximab) in spondyloarthropathy: an open pilot study显示文摘 | van den Bosch F Kruithof E Baeten D | 2000 | Annals of the Rheumatic Disease2000，，： | 2 |
| 6 | Medical image matching-a review with classification 显示文摘 | VAN DEN ELSEN P A POL E J D VIERGEVER M A | 1993 | IEEE Eng in Med & Biol1993，12，1： | 2 |
| 7 | Effect of 1,2-propanediol and dimethylsulphoxide on the meiotic spindle of the mouse oocytes显示文摘 | Van der Elst J van den Abbeel E Jacobs R | 1988 | Hum Reprod1988，3，： | 2 |
| 8 | The carboxyl-terminal part of the putative Berne virus polymerase is expressed by ribosomal frameshifting and contains sequence motifs which indicate that toro- and eoronaviruses are evolutionarily related 显示文摘 | Snijder E J den Boon J A Bredenbeek P J | 1990 | Nucleic Acids Res1990，18，： | 1 |
| 9 | An intrusion-detection model 显示文摘 | | 1987 | IEEE Transactions on Software Engineering1987，13，2： | 1 |
| 10 | eal-time PCR assay for the identification of Thrips palmi显示文摘 | KOX L F F van den BELD H E ZIJLSTRA C | 2005 | Bulletin OEPP/EPPO Bulletin2005，35，： | 1 |
| 11 | Organic carbon in soils of the world显示文摘 | ESWARRAN H E VAN DEN BERG E V REICH P | 1993 | Soil Science Society of America Journal1993，57，： | 1 |
| 12 | Treatment of asperginosis:Clinical prcatice guidelines of the infectious diseases society of America显示文摘 | Walsh T J Anaissie E J Denning D W | 2008 | Clin Infect Dis2008，46，： | 1 |
| 13 | Cell transplantation for cardiac regenerarion:where do we stand? 显示文摘 | van den Bos E J van der Giessen WJ Duncker DJ | 2008 | Neth Heart J2008，16，3： | 1 |
| 14 | Influence of swirl on theinitial merging zone of a turbulent annular jet 显示文摘 | Vanierschot M van den Bulck E | 2008 | Physics of Fluids2008，20，10： | 1 |
| 15 | A Lattice Model of Secure Information Flow显示文摘 | D E Denning | 1976 | Communications of the ACM1976，19，5： | 1 |
| 16 | Randomized study to compare balloon angioplasty and elective stent implantation in venous bypass grafts: the venestent study 显示文摘 | Hanekamp C E E Jacques J K den Heijer P | 2003 | Catheter Cardiovasc Interv2003，60，： | 1 |
| 17 | Molecular and biological characterization of human monoclonal antibodies bingding to the spike and nucleocapsid proteins of Severe Acute Respiratory Syndrome Coronavirus显示文摘 | Van den Brink E N Meulen J Cox F | 2005 | J Virol2005，79，： | 1 |
| 18 | An Intrusion Detection Model 显示文摘 | Dorothy E Denning | 1987 | IEEE Transactions on Software Engineering1987，13，2： | 1 |
| 19 | Organic car- bon in soils of the world显示文摘 | ESWARAN H Van den Berg E Reich P | 1993 | Soil Sei Soc Amer J1993，57，： | 1 |
| 20 | Feeder - free culture of human embryonic stem cells in conditioned medium for efficient genetic mod- ification 显示文摘 | Braam SR Denning C Matsa E | 2008 | Nat Protoc2008，3，9： | 1 |
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