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| 1 | Compliance Analysis of a 3-DOF Spindle Head by Considering Gravitational Effects显示文摘The compliance modeling is one of the most significant issues in the stage of preliminary design for parallel kinematic machine(PKM). The gravity ignored in traditional compliance analysis has a significant effect on pose accuracy of tool center point(TCP) when a PKM is horizontally placed. By taking gravity into account, this paper presents a semi-analytical approach for compliance analysis of a 3-DOF spindle head named the A3 head. The architecture behind the A3 head is a 3-RPS parallel mechanism having one translational and two rotational movement capabilities, which can be employed to form the main body of a 5-DOF hybrid kinematic machine especially designed for high-speed machining of large aircraft components. The force analysis is carried out by considering both the externally applied wrench imposed upon the platform as well as gravity of all moving components. Then, the deflection analysis is investigated to establish the relationship between the deflection twist and compliances of all joints and links using semi-analytical method. The merits of this approach lie in that platform deflection twist throughout the entire task workspace can be evaluated in a very efficient manner. The effectiveness of the proposed approach is verified by the FEA and experiment at different configurations and the results show that the discrepancy of the compliances is less than 0.04 μm/N-1 and that of the deformations is less than 10μm. The computational and experimental results show that the deflection twist induced by gravity forces of the moving components has significant bearings on pose accuracy of the platform, providing an informative guidance for the improvement of the current design. The proposed approach can be easily applied to the compliance analysis of PKM by considering gravitational effects and to evaluate the deformation caused by gravity throughout the entire workspace. | LI Qi WANG Manxin HUANG Tian CHETWYND G Derek | 2015 | Chinese Journal of Mechanical Engineering2015,28,1: | 11 |
| 2 | A semi-analytical approach for stiffness modeling of PKM by considering compliance of machine frame with complex geometry显示文摘Stiffness modeling is one of the most significant issues in the design of parallel kinematic machine (PKM). This paper presents a semi-analytical approach that enables the stiffness of PKM with complex machine frame geometry to be estimated effectively. This approach can be implemented by three steps: (i) decomposition of the entire system into two sub-systems associated with the parallel mechanism and the machine frame respectively; (ii) stiffness modeling of each sub-system using the analytical approach and the finite element analysis; and (iii) generation of the stiffness model of the entire system by means of linear superposition. In the modeling process of each sub-system, the virtual work princi- ple and overall deflection Jacobian are employed with special attention to the bending rigidity of the constrained passive limb and the interface stiffness of the machine frame. The stiffness distribution of a 5-DOF hybrid robot named TriVariant-B is investigated as an example to illustrate the effectiveness of this approach. The contributions of component rigidities to that of the system are evaluated using global indices. It shows that the results achieved by this approach have a good match to those obtained through finite element analysis and experiments. | WANG YouYu HUANG Tian ZHAO XueMan MEI JiangPing Derek G CHETWYND | 2008 | Chinese Science Bulletin2008,53,16: | 4 |
| 3 | Diagnosis and surgical management of breast cancer metastatic to the spine显示文摘Breast cancer is the most common malignancy and the second leading cause of death in Western women. Breast cancer most commonly metastasizes to the bone and has a particular affinity with the spine, accounting for 2/3 of osseous metastases discovered. With significant improvements in cancer therapies, the number of patients at risk for symptomatic spinal metastases is likely to increase. Patients may suffer from intractable pain and neurological dysfunction, negatively influencing their quality of life. Timely diagnosis of patients is crucial and has been aided by several breakthrough advances in imaging techniques which aid in detection, staging, and follow-up of bone metastases. Breast metastases are usually responsive to hormonal therapy and pharmacologic interventions, but skeletal metastases often require surgical intervention. The treatments are palliative but goals include the preserving or restoring neurologic function, ensuring spinal stability, and relieving pain. Advances in surgical techniques and instrumentation have allowed more effective decompres-sion and stabilization of the spine, and with the support of recent evidence the trend has shifted towards using more advanced surgical options in appropriately selected patients. In this review, the clinical presentation, diagnosis, patient selection, and surgical management of breast cancer metastatic to the spine are discussed. | Derek G Ju Alp Yurter Ziya L Gokaslan Daniel M Sciubba | 2014 | World Journal of Clinical Oncology2014,5,3: | 4 |
| 4 | Non-invasive detection of vulnerable coronary plaque显示文摘Critical coronary stenosis have been shown to contribute to only a minority of acute coronary syndromes and sudden cardiac death.Autopsy studies have identified a subgroup of high-risk patients with disrupted vulnerable plaque and modest stenosis.Consequently,a clinical need exists to develop methods to identify these plaques prospectively before disruption and clinical expression of disease.Recent advances in invasive and non-invasive imaging techniques have shown the potential to identify these high-risk plaques.Non-invasive imaging with magnetic resonance imaging,computed tomography and positron emission tomography holds the potential to differentiate between low-and highrisk plaques.There have been significant technological advances in non-invasive imaging modalities,and the aim is to achieve a diagnostic sensitivity for these technologies similar to that of the invasive modalities.Molecular imaging with the use of novel targeted nanoparticles may help in detecting high-risk plaques that will ultimately cause acute myocardial infarction.Moreover,nanoparticle-based imaging may even provide non-invasive treatments for these plaques.However,at present none of these imaging modalities are able to detect vulnerable plaque nor have they been shown to definitively predict outcome.Further trials are needed to provide more information regarding the natural history of high-risk but non-flow-limiting plaque to establish patient specific targeted therapy and to refine plaque stabilizing strategies in the future. | Faisal Sharif Derek G Lohan William Wijns | 2011 | World Journal of Cardiology2011,3,7: | 2 |
| 5 | Diffusion with hydrolysis and ion association in aqueous solutions of beryllium sulfate 显示文摘 | Hao Ling Lu Ruanhui Derek G L | 1996 | Journal of Solution Chemistry1996,25,3: | 1 |
| 6 | WNT signaling in ovarian follicle biology and tumorigenesis显示文摘 | Alexandre B Alan K G Derek B | 2009 | Trends in Endocrinology and Metabolism2009,21,1: | 1 |
| 7 | Lethal and sub-lethal effects of the salmon delousing agent dichlorvos on the larvae of the lobster (Homarus gammarus L) and herring (Clupea harengus L)显示文摘 | JOHN G M DEREK S DUNCAN D S | 1991 | Aquaculture1991,98,: | 1 |
| 8 | Volume rendering versus maximum intensity projection in CT angiography显示文摘 | Elliot KF Derek RN David G | 2006 | Radio Graphics2006,26,3: | 1 |
| 9 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008,,6: | 1 |
| 10 | New insights into magnetic derivatives for structural mapping显示文摘 | Derek J Airhead F Chris G M | 2004 | The Leading Edge2004,23,2: | 1 |
| 11 | Short-term alcohol and drug treatment outcomes predict long-term outcome显示文摘 | Constance Weisner G Thomas Ray Jennifer R Mertens Derek D Satre Charles Moore | 2003 | Drug and Alcohol Dependence2003,,3: | 1 |
| 12 | A general and novel approach for parameter identification of 6-DOF parallel kinematic machines显示文摘 | Huang Tian Chetwynd Derek G David J | 2005 | Mechanism and Machine Theory2005,40,2: | 1 |
| 13 | Modeling Terrestrial Laser Scanner Data for Precise Structural Deformation Measurement显示文摘 | Stuart J G Derek D L | 2007 | Journal of Surveying Engineering2007,,5: | 1 |
| 14 | Surface grafting of cellulose nanocrystals with poly(ethylene oxide) in aqueous media显示文摘 | Elisabeth K Derek G G | 2010 | Langrnuir2010,26,13: | 1 |
| 15 | CNMR spectra of nylon 6/12 eopolymers and related model compounds 显示文摘 | ISAAC G DEREK J ARISTIDES H | 2000 | European Polymer Journal2000,36,7: | 1 |
| 16 | Application of the equilibriumplanformconcept to natural beaches in Northern Ireland显示文摘 | Derek W T Jackson J Andrew G C | | 0,,: | 1 |
| 17 | Use of Medical Comorbidifies to Predict Complications after Hip Frature Surgery in the Elderly显示文摘 | Derek J Donegan A Nicolas G | 2010 | J Bone Joint Surg Am2010,92,4: | 1 |
| 18 | Investigation of the Use of a Stacked HPGe Detector for Improving Gamma Ray Spectra at Energies above 2MeV显示文摘 | Darren G S Derek B Klaus F | 2005 | Nucl Instrum Meth A2005,536,: | 1 |
| 19 | Preparation and properties of semicon ducting polycrystalline tin oxide 显示文摘 | Colin A V Derek G C | 1972 | Solid States Science and Technology1972,119,4: | 1 |
| 20 | Parabolic focal conics in self-assembled solid films of cellulose nanocrystals 显示文摘 | Roman Maren Gray Derek G | 2005 | Langmuir2005,21,12: | 1 |