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78篇 您的检索式：作者名="Deumens"

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	题名	作者	年代	出处	被引量
1	Fibroadhesive scarring of grafted collagen scaffolds interferes with implant–host neural tissue integration and bridging in experimental spinal cord injury显示文摘Severe traumatic spinal cord injury(SCI)results in a devastating and permanent loss of function,and is currently an incurable condition.It is generally accepted that future intervention strategies will require combinational approaches,including bioengineered scaffolds,to support axon growth across tissue scarring and cystic cavitation.Previously,we demonstrated that implantation of a microporous type-I collagen scaffold into an experimental model of SCI was capable of supporting functional recovery in the absence of extensive implant–host neural tissue integration.Here,we demonstrate the reactive host cellular responses that may be detrimental to neural tissue integration after implantation of collagen scaffolds into unilateral resection injuries of the adult rat spinal cord.Immunohistochemistry demonstrated scattered fibroblast-like cell infiltration throughout the scaffolds as well as the presence of variable layers of densely packed cells,the fine processes of which extended along the graft–host interface.Few reactive astroglial or regenerating axonal profiles could be seen traversing this layer.Such encapsulation-type behaviour around bioengineered scaffolds impedes the integration of host neural tissues and reduces the intended bridging role of the implant.Characterization of the cellular and molecular mechanisms underpinning this behaviour will be pivotal in the future design of collagen-based bridging scaffolds intended for regenerative medicine.	Haktan Altinova Sebastian Hammes Moniek Palm Jose Gerardo-Nava Pascal Achenbach Ronald Deumens Emmanuel Hermans Tobias Fuhrmann Arne Boecker Sabien Geraldine Antonia van Neerven Ahmet Bozkurt Joachim Weis Gary Anthony Brook	2019	Regenerative Biomaterials2019，6，2：	4
2	Modeling Parkinson's disease in rats:an evaluation of 6-OHDA lesions of the nigrostriatal pathway显示文摘	DEUMENS R BLOKLAND A PRICKAERTS J	2002	Exp Neurol2002，175，2：	1
3	Modeling Parkinson's disease in rat:an evaluation of 6-OHDA lesionsof the nigrostriatal pathway显示文摘	Deumens R Blokland A Prickaerts J	2002	Exp Neurol2002，175，2：	1
4	Prevention of chronic postoperative pain: cellular, molecular, and clinical insights for mechanism-based treatment approaches显示文摘	Deumens R Steyaert A Forget P	2013	Prog Neurobiol2013，104，：	1
5	Modeling Parkinson's disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway显示文摘	Blokland A Prickaerts J	2002	Exp Neurol2002，175，：	1
6	Modeling Parkinson's disease in rat:an evaluation of 6-OHDA lesions of the nigrostriatal pathway显示文摘	Deumens R Blokland A Prickaerts J	2002	Exp Neurol2002，175，2：	1
7	Modeling Parkinson's disease in rats:an evaluation of 6-OHDA lesions of the nigrostriatal pathway显示文摘	Deumens R Blokland A Prickaerts J	2002	Exp Neurol2002，175，2：	1
8	Modeling Parkinson's disease in rat: an evaluation of 6-OHDA lesions of the nigrestriatal pathway显示文摘	Deumens R Blokland A Prickaerts J	2002	Exp Neurol2002，175，2：	1
9	The CatWalk gait analysis in assessment of both dynamic and static gai', changes after adult rat sciatic nerve resection显示文摘	Deumens R Jaken RJ Marcus MA	2007	J Neuro- sci Methods2007，，12：	1
10	Modeling Parkinson's disease in rats:an evaluation of 6-OHDA lesions of the nigrostriatal pathway显示文摘	Deumens R Blokland A Prickaerts J	2002	Exp Neurol2002，175，2：	1
11	Modeling Parkinson's disease in rats:An evaluation of 6-OHDA lesions of the nigrostriatal pathway显示文摘	Deumens R Blokland A Prickaerts J	2002	Exp Neurol2002，175，2：	1
12	Regeneration of descending axon tracts after spinal cord injury显示文摘	Deumens R Koopmans GC Joosten EA	2005	Prog Neurobiol2005，77，12：	1
13	The assessment of locomotor function in spinal cord injured rats:the importance of objective analysis of coordination显示文摘	Koopmans Gc Deumens R Honing WM	2005	J Neurotrauma2005，22，2：	1
14	Influence of intrathecal delivery of bone marrow-derived mesenchymal stem cells on spinal inflammation and pain hypersensitivity in a rat model of peripheral nerve injury 显示文摘	Schafer S Berger JV Deumens R	2014	J Neuroinflamm2014，11，：	1
15	Alignment of glial cells stimulates directional neurite growth of CNS neurons in vitro显示文摘	Deumens R Koopmans GC Den Bakker CG	2004	Neuroscience2004，125，3：	1
16	Modeling Parkinson' s disease in rats: a evaluation of 6-OHDA lesions of the nigrostriatal pathway显示文摘	Deumens R Blokland A Priekaerts J	2002	Exp Neurol2002，175，2：	1
17	Modeling Parkinson' s disease in rat : an evaluation of 6-OHDA lesions of the nigrostria- tal pathway 显示文摘	Deumens R Blokland A Prickaerts J	2002	Exp Neurol2002，175，：	1
18	Alignment of glial cells stimulates directional neurite growth of CNS neurons in vitro 显示文摘	DEUMENS R KOOPMANS G C DEN BAKKER C G	2004	Neuroscience2004，125，：	1
19	Modeling Parkinson's disease in rat :an evaluation of 6-OHDA lesions of the nigrostriatal pathway显示文摘	Deumens R Blokland A Priekaerts J	2002	Exp Neurol2002，175，：	1
20	Alignment of glial cells stimulates directional neurite growth of CNS neurons in vitro显示文摘	Deumens R Koopmans G C Den Bakker C G	2004	Neuroscience2004，125，：	1

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