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| 1 | Celiac disease:Management of persistent symptoms in patients on a gluten-free diet显示文摘AIM:To investigate all patients referred to our center with non-responsive celiac disease (NRCD),to establish a cause for their continued symptoms.METHODS:We assessed all patients referred to our center with non-responsive celiac disease over an 18-mo period.These individuals were investigated to establish the eitiology of their continued symptoms.The patients were first seen in clinic where a thorough history and examination were performed with routine blood work including tissue transglutaminase antibody measurement.They were also referred to a specialist gastroenterology dietician to try to identift any lapses in the diet and sources of hidden gluten ingestion.A repeat small intestinal biopsy was also performed and compared to biopsies from the referring hospital where possible.Colonoscopy,lactulose hydrogen breath testing,pancreolauryl testing and computed tomography scan of the abdomen were undertaken if the symptoms persisted.Their clinical progress was followed over a minimum of 2 years.RESULTS:One hundred and twelve consecutive patients were referred with NRCD.Twelve were found not to have celiac disease (CD).Of the remaining 100 patients,45% were not adequately adhering to a strict gluten-free diet,with 24 (53%) found to be inadvertently ingesting gluten,and 21 (47%) admitting noncompliance.Microscopic colitis was diagnosed in 12% and small bowel bacterial overgrowth in 9%.Refractory CD was diagnosed in 9%.Three of these were diagnosed with intestinal lymphoma.After 2 years,78 patients remained well,eight had continuing symptoms,and four had died.CONCLUSION:In individuals with NRCD,a remediable cause can be found in 90%:with continued gluten ingestion as the leading cause.We propose an algorithm for investigation. | David H Dewar Suzanne C Donnelly Simon D McLaughlin Matthew W Johnson H Julia Ellis Paul J Ciclitira | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 2 | The adoption of radical and incremental innovations:An empirical analysis显示文摘 | Dewar R D Dutton J E | | 0，，11： | 1 |
| 3 | Nature of the transition state in some Diels-Alder reactions 显示文摘 | DEWAR M J S PYRON R S | 1970 | J Am Chem Soc1970，10，92： | 1 |
| 4 | The adoption of radical and incremental innovations:An empirical analysis显示文摘 | Dewar R D Dutton J E | 1984 | Management Science1984，30，： | 1 |
| 5 | The glutamine 27 beta2-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families 显示文摘 | Dewar JC Wilkinson J Weatley A | 1997 | J Allergy Clin Immunol1997，100，2： | 1 |
| 6 | Psychiatric trai- t nees experiences and reactions to, patient suicide显示文摘 | Dewar I G Eagles J M Klein S | 2000 | Psychiatr Bull2000，24，1： | 1 |
| 7 | AM1:A new general purpose quantum mechanical molecular model显示文摘 | Dewar M J S Zoebisch E G Healy E F | | 0，，： | 1 |
| 8 | Promoting end - of - life care in nursing homes using an integrated care pathway for the last days of life显示文摘 | Hockley J Dewar B Watson J | 2005 | Journal of Research on Nursing2005，10，2： | 1 |
| 9 | Prevalence of adenovirus antigens in children presenting with acute diarrhoea 显示文摘 | Fodha I Chouikha A Dewar J | 2007 | Med Trop2007，67，3： | 1 |
| 10 | The adoption of radical and incremental innovations an empirical analysis 显示文摘 | DEWAR R D DUTTON J E | 1986 | Man- agement science1986，32，11： | 1 |
| 11 | AM1 :a new general purpose quantum mechanical molecular model显示文摘 | Dewar M J S Zoebisch E G Healy E F | 1985 | J Am Chem Soc1985，107，： | 1 |
| 12 | Telephone follow-up for day sur- gery patients:patients perceptions and nurses experiences 显示文摘 | Dewar A Scott J Muir J | 2004 | J Perianesth Nuts2004，19，4： | 1 |
| 13 | Quantitative assessment of ischemic pathology in axons, oligodendrocytes, and neurons: attenuation of damage after transient ischemia显示文摘 | Valeriani V Dewar D Mcculloch J | 2000 | J Cereb Blood Flow Metab2000，20，： | 1 |
| 14 | Factors affecting cervical anastigmatic leak and stricture formation following esopha- gogastrostomy and gastric tube interposition显示文摘 | Dewar L Gelfand G Finley R J | 2008 | Am J Surg2008，5，： | 1 |
| 15 | Initial paclitaxel improves outcome compared with CMFP combination chemotherapy as front-line therapy in untreated metastatic breast cancer显示文摘 | Dewar J Toner GC | 1999 | J Clin Oncol1999，17，： | 1 |
| 16 | The Adoption of Radical and Incremental Innovations: An Empirical Analysis 显示文摘 | DEWAR R D DUTTON J E | 1986 | Management Science1986，32，11： | 1 |
| 17 | A radical approach to sroke therapy显示文摘 | McCulloch J Dewar D | 2001 | Proc Natl Acad Sci USA2001，98，10： | 1 |
| 18 | Mean TS, SZ and TZ curve for the North Atlantic and the North Pacific显示文摘 | EMERY W J DEWAR J S | 1982 | Progress of Oceanography1982，11，： | 1 |
| 19 | Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial显示文摘 | Jayant S Vaidya David J Joseph Jeffrey S Tobias Max Bulsara Frederik Wenz Christobel Saunders Michael Alvarado Henrik L Flyger Samuele Massarut Wolfgang Eiermann Mohammed Keshtgar John Dewar Uta Kraus-Tiefenbacher Marc Sütterlin Laura Esserman Helle MR Ho | 2010 | The Lancet2010，，9735： | 1 |
| 20 | AMI: A new general purpose quantum mechanical molecular model 显示文摘 | DEWAR M J S ZOEBISCH E G HEALY E F | 1985 | J Am Chem Soc1985，107，13： | 1 |
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