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| 1 | Performance of liver stiffness measurements by transient elastography in chronic hepatitis显示文摘AIM:To compare results of liver stiffness measurements by transient elastography(TE) obtained in our patients population with that used in a recently published meta-analysis.METHODS:This was a single center cross-sectional study.Consecutive patients with chronic viral hepatitis scheduled for liver biopsy at the outpatient ward of our Infectious Diseases Department were enrolled.TE was carried out by using FibroScan(Echosens,Paris,France).Liver biopsy was performed on the same day as TE,as day case procedure.Fibrosis was staged according to the Metavir scoring system.The diagnostic performance of TE was assessed by using receiver operating characteristic(ROC) curves and the area under the ROC curve analysis.RESULTS:Two hundred and fifty-two patients met the inclusion criteria.Six(2%) patients were excluded due to unreliable TE measurements.Thus,246(171 men and 75 women) patients were analyzed.One hundred and ninety-five(79.3%) patients had chronic hepatitis C,41(16.7%) had chronic hepatitis B,and 10(4.0%) were coinfected with human immunodeficiency virus.ROC curve analysis identified optimal cut-off value of TE as high as 6.9 kPa forF ≥ 2;7.9 kPa forF ≥ 3;9.6 kPa for F = 4 in all patients(n = 246),and as high as 6.9 kPa for F ≥ 2;7.3 kPa for F ≥ 3;9.3 kPa for F = 4 in patients with hepatitis C(n = 195).Cut-off values of TE obtained by maximizing only the specificity were as high as 6.9 kPa for F ≥ 2;9.6 kPa for F ≥ 3;12.2 kPa for F = 4 in all patients(n = 246),and as high as 7.0 kPa forF ≥ 2;9.3 kPa forF ≥ 3;12.3 kPa forF = 4 in patients with hepatitis C(n = 195).CONCLUSION:The cut-off values of TE obtained in this single center study are comparable to that obtained in a recently published meta-analysis that included up to 40 studies. | Giovanna Ferraioli Carmine Tinelli Barbara Dal Bello Mabel Zicchetti Raffaella Lissandrin Gaetano Filice Carlo Filice Elisabetta Above Giorgio Barbarini Enrico Brunetti Willy Calderon Marta Di Gregorio Roberto Gulminetti Paolo Lanzarini Serena Ludovisi Laura Maiocchi Antonello Malfitano Giuseppe Michelone Lorenzo Minoli Mario Mondelli Stefano Novati Savino FA Patruno Alessandro Perretti Gianluigi Poma Paolo Sacchi Domenico Zanaboni Marco Zaramella | 2013 | World Journal of Gastroenterology2013，19，1： | 18 |
| 2 | Platelets and inflammation: Role of platelet-derived growth factor, adhesion molecules and histamine显示文摘 | P. F. Mannaioni M. G. Di Bello E. Masini | 1997 | Inflammation Research1997，，1： | 1 |
| 3 | Microalbuminuria,an integrated marker of cardiovascular risk in essential hypertension显示文摘 | Pedrinelli R Dell'Omo G Di Bello V | 2002 | Hum Hypertens2002，16，2： | 1 |
| 4 | Low-grade inflammation and microalbuminuria in hypertension显示文摘 | Pedrinelli R Dell'Omo G Di Bello V | 2004 | Arterioscler Thromb Vasc Biol2004，24，12： | 1 |
| 5 | Increased myocardial ultrasonic reflectivity is associated with extreme hypertensive left ventricular hypertrophy: a tissue characterization study in humans显示文摘 | Lucarini A R Talarico L Di Bello V | 1998 | Am J Hypertens1998，11，12： | 1 |
| 6 | Microalbuminuria,pulse pressure,left ventricular hypertrophy,and myocardial ultrasonic tissue characterization in essential hypertension显示文摘 | Di Bello V Pedrinelli R Giorgi D | 2001 | Angiology2001，52，： | 1 |
| 7 | Coronary microcirculation in essential hypertension: a quantitative myocardial contrast echocardiographic approach 显示文摘 | Di Bello V Pedrinelli R Giorgi D | 2002 | Eur J Echocardiogr2002，3，2： | 1 |
| 8 | Histamine release from rat mast cells induced by the metabolic activation of drugs of abuse into free radicals显示文摘 | M. G. Di Bello E. Masini C. Ioannides J. Fomusi Ndisang S. Raspanti T. Bani Sacchi P. F. Mannaioni | 1998 | Inflammation Research1998，，3： | 1 |
| 9 | Blood pressure inde- pendent association of microalbuminuria and left ventricular hy- pertrophy in hypertensive men显示文摘 | Dellbmo G Giorgi D Di Bello V | 2003 | J Intern Med2003，254，1： | 1 |
| 10 | Microalbuminuna, an in- tegrated manker of cardiovascufar risk in essential hypertersion 显示文摘 | Pedrinelli R Dell' Omo G Di Bello V | 2002 | J Hum Hypertens2002，16，2： | 1 |
| 11 | Carotid intima-media thickness in asymptomatic patients with arterial hypertension without clinical cardiovascular disease:relation with left ventricular geometry and mass and coexisting risk factors显示文摘 | Di Bello V Carerj S Perticone F | 2009 | Angiology2009，60，6： | 1 |
| 12 | Physiological variation of the myocardial integrated backscatter signal in athlete's heart显示文摘 | Giorgi D Di Bello V Bertini A | 2000 | International Journal of Sports Medicine2000，21，： | 1 |
| 13 | Evidence for an in-creased rate of cardiovascular events in patients with primary al-dosteronism显示文摘 | Rossi GP Di Bello V Ganzaroli C | 2005 | J Am Coll Cardiol2005，45，8： | 1 |
| 14 | Early left ventricular longitudinal systolic dysfunction and cardio vascular risk factors in 1 371 asymptomatic subjects with normal ejection fraction: a tissue Doppler study 显示文摘 | Di Salvo G Di Bello V Salustri A | 2011 | Echocardiography2011，28，3： | 1 |
| 15 | Pulmonary complications after descending thoracic and thoracoabdomial aortic aneurysm repair:predictors,prevention,and treatment显示文摘 | Etz CD Di Luozzo G Bello R | | 0，，： | 1 |
| 16 | Cyclic variation of the myocardial integrated backscatter signal in hypertensive cardiopathy: a preliminary study显示文摘 | Di Bello V Pedrinelli R Bertini A | 2001 | Coron Artery Dis2001，12，： | 1 |
| 17 | Ultrasonic myocardial texture versus Dopplei analysis in hypertensive heart:A preliminary study 显示文摘 | Di Bello V Pedrinelli R Giorgi D | 1999 | Hypertension1999，33，： | 1 |
| 18 | Severe aortic stenosis and myocardial function: diagnostic and prognostic usefulness of ultra- sonic integrated backscatter analysis 显示文摘 | Di Bello V Giorgi D Viacava P | 2007 | Circulation2007，110，7： | 1 |
| 19 | Homoeysteine induces expression and secretion of mon- ocyte chemoattractant protein-1 and interleukin-8 in human aor- tic endothelial cells:implications for vascular disease 显示文摘 | Poddar R Sivasubramanian N Di Bello PM Robinson K Jacobs- en DW | 2001 | Cir- culations2001，103，23： | 1 |
| 20 | Increased echodensity of myocardial wall in the diabetic hearts:An Ultrasound Tissue Characterization Study显示文摘 | di Bello V Talarico L Picano E | 1995 | JACC1995，25，6： | 1 |
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