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| 1 | Radiofrequency ablation vs surgical resection in elderly patients with hepatocellular carcinoma in Milan criteria显示文摘BACKGROUND Surgical resection and radiofrequency ablation(RFA)represent two possible strategy in treatment of hepatocellular carcinoma(HCC)in Milan criteria.AIM To evaluate short-and long-term outcome in elderly patients(>70 years)with HCC in Milan criteria,which underwent liver resection(LR)or RFA.METHODS The study included 594 patients with HCC in Milan criteria(429 in LR group and 165 in RFA group)managed in 10 European centers.Statistical analysis was performed using the Kaplan-Meier method before and after propensity score matching(PSM)and Cox regression.RESULTS After PSM,we compared 136 patients in the LR group with 136 patients in the RFA group.Overall survival at 1,3,and 5 years was 91%,80%,and 76%in the LR group and 97%,67%,and 41%in the RFA group respectively(P=0.001).Diseasefree survival at 1,3,and 5 years was 84%,60%and 44%for the LR group,and 63%,36%,and 25%for the RFA group(P=0.001).Postoperative Clavien-Dindo IIIIV complications were lower in the RFA group(1%vs 11%,P=0.001)in association with a shorter length of stay(2 d vs 7 d,P=0.001).In multivariate analysis,Model for End-stage Liver Disease(MELD)score(>10)[odds ratio(OR)=1.89],increased value of international normalized ratio(>1.3)(OR=1.60),treatment with radiofrequency(OR=1.46),and multiple nodules(OR=1.19)were independent predictors of a poor overall survival while a high MELD score(>10)(OR=1.51)and radiofrequency(OR=1.37)were independent factors associated with a higher recurrence rate.CONCLUSION Despite a longer length of stay and a higher rate of severe postoperative complications,surgery provided better results in long-term oncological outcomes as compared to ablation in elderly patients(>70 years)with HCC in Milan criteria. | Maria Conticchio Riccardo Inchingolo Antonella Delvecchio Letizia Laera Francesca Ratti Maximiliano Gelli Ferdinando Anelli Alexis Laurent Giulio Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño AntonioRampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 2 | Coronary physiology assessment in the catheterization laboratory显示文摘Physicians cannot rely solely on the angiographic appearance of epicardial coronary artery stenosis when evaluating patients with myocardial ischemia. Instead, sound knowledge of coronary vascular physiology and of the methods currently available for its characterization can improve the diagnostic and prognostic accuracy of invasive assessment of the coronary circulation, and help improve clinical decision-making. In this article we summarize the current methods available for a thorough assessment of coronary physiology. | Felipe Díez-delhoyo Enrique Gutiérrez-Ibanes Gerard Loughlin Ricardo Sanz-Ruiz María Eugenia Vázquez-álvarez Fernando Sarnago-Cebada Rocío Angulo-Llanos Ana Casado-Plasencia Jaime Elízaga Francisco Fernández Avilés Diáz | 2015 | World Journal of Cardiology2015，7，9： | 2 |
| 3 | Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence显示文摘 | Juan C. Acosta Ana O’Loghlen Ana Banito Maria V. Guijarro Arnaud Augert Selina Raguz Marzia Fumagalli Marco Da Costa Celia Brown Nikolay Popov Yoshihiro Takatsu Jonathan Melamed Fabrizio d’Adda di Fagagna David Bernard Eva Hernando Jesús Gil | 2008 | Cell2008，，6： | 2 |
| 4 | Small-scale spatial variability of selected soil biological properties显示文摘 | C.H.E. Stark L.M. Condron A. Stewart H.J. Di M. O’Callaghan | 2004 | Soil Biology and Biochemistry2004，，4： | 2 |
| 5 | Coronary artery calcification progression is associated with arterial stiffness and cardiac repolarization deterioration in hemodialysis patients显示文摘 | Di Iorio B Nargi O Cucciniello E | 2011 | Kidney Blood Press Res2011，34，： | 1 |
| 6 | Waist circum- ference and abdominal sagittal diameter as surrogates of body fat distribution in the elderly: their relation with cardiovascular risk factors 显示文摘 | Turcato E Bosello O Di Francesco V | 2000 | Int J Obes Relat Metab Disord2000，24，8： | 1 |
| 7 | Optimal existence theory for single and multiple positive periodic solutions to functional difference equations显示文摘 | DI QING-jiang O'REGAN D AGARWAL R P | 2005 | Appl Math Letters2005，161，： | 1 |
| 8 | Acceleration of monte carlo modeling of light transport in turbid media; an approach based on hybrid, theoretical and numerical, calculations 显示文摘 | Di Rocco H O Iriarte D I Pomarico J A | 2009 | Journal of Quantitative Spec- troscopy & Radiative Transfer2009，110，： | 1 |
| 9 | Effects of trimetazidine administration before thrombolysis inpatients with anterior myocardial infarction:short-term and long-term results显示文摘 | Di Pasquale P Lo Verso O Bucca V | 2002 | Cardiovasc Drug Ther2002，13，： | 1 |
| 10 | A Dynamic Model of Phytoplankton Population In the sacramento San Joaquin Delta显示文摘 | Di toro D M O'Connor D J Thomann T V | 1971 | Advances in Chemistry American Chemical Society1971，106，： | 1 |
| 11 | Drug-eluting bioabsorbable magnesium stent显示文摘 | Di Mario C Griffiths H Goktekin O | 2004 | J Int Cardiology2004，17，6： | 1 |
| 12 | Frequency and clinical features of multiple tumors of the large bowel in the general population and in patients with hereditary colorectal carcinomas 显示文摘 | Fante R Roncucci L Di Gregorio O | 1996 | Cancer1996，77，： | 1 |
| 13 | A controlled trial of modified electroeonvulsive therapy in schizophrenia in a Nigerian teaching hospital显示文摘 | Ukpong DI Makanjuola RO Morakinyo O | 2002 | West Afr J Meal2002，21，3： | 1 |
| 14 | Effects of paroxetine hydrochloride, a selective serotonin reuptake inhibitor, on refractory vasovagal syncope: a randomized, double - blind, placebo controlled study显示文摘 | Di Gerolamo E Di Iorio C Sabatini O | 1999 | J Am Coll Cardiol1999，33，5： | 1 |
| 15 | Density-functional calculations of the structures, binding energies, and magnetic moments of Fe clusters with 2 to 17 atoms显示文摘 | Di e guez O Alemany M M G Rey C | 2001 | Phys Rev B2001，63，： | 1 |
| 16 | Preeelampsia is assoeiated with widespread apoptosis of placental cytotrophoblasts within the uterine wall显示文摘 | Di Federieo E Genbacev O Fisher SJ | 1999 | Am J Pathol1999，155，1： | 1 |
| 17 | Characterization of regulatory T cells identified as CD4 (+)CD25 (high)CD39(+) in patients with aclive tuberculosis显示文摘 | Chiacchio T Casetti R Butera O Vanini V Carrara S Girardi E Di Mitri D Battistini L Martini F Borsellino G Goletti D | 2009 | Clin Exp Immunol2009，156，3： | 1 |
| 18 | Endophytic fungi in indigenous Australian grasses associated with toxicity to livestock显示文摘 | Miles C O di Menna M E Jacob S W L | 1998 | Applied and Environmental Microbiology1998，64，： | 1 |
| 19 | Adrenocortical oncocytic tymors:report of 10 cases and review of literature 显示文摘 | Bisceglia M Ludovico O Di Mattia A | 2004 | IntJ Surg Pathol2004，12，3： | 1 |
| 20 | Risk of embolism and death in infective endocarditis:prognostic value of echocardiography:a prospective multicenter study显示文摘 | Thuny F Di Salvo G Belliard O | 2005 | Circulation2005，112，： | 1 |
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