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| 1 | Study on Age and Education Level and Their Relationship with Fall-Related Injuries in Shanghai, China显示文摘Objective To study age and educational level and their relationship with fall-related injuries in Shanghai and to analyze the relevant costs. Methods Multistage cluster sampling was used for the selection of participants and standardized questionnaires were used for the information collection in 2006. Information on cases and deaths caused by fall-related injuries were obtained from 494 hospitals as well as from the mortality registry systems from 2001 till 2010. Results Of 45 857 participates, 674 suffered from fall-related injuries with the largest proportion among all injuries. The fall-related mortality increased from 10.63 per 100 000 in 2001 to 14.11 per 100 000 in 2010. The under-five mortality rate was the highest among children aged 0-14 years. Mortality increased dramatically among those aged 55 or above for the female and aged 60 or older for the male. Individuals with an educational level under the primary school were more likely to suffer fall-related injuries, accounting for 72.66% of all deaths and 49.24% of nonfatal cases respectively. The annual burden of fall-related injuries equated to 25.90% of the share of GDP for the healthcare, social security and welfare industries in 2006. Conclusion Fall-related injuries were inversely related to victims' educational level. Children under the age of 5, women over 55 years old and men over 60 years old with an educational level lower than the primary school are the most risky groups of populations for intervention measures. | LI Yan Hong SONG Gui Xiang YU Yan ZHOU De Ding ZHANG Hong Wei | 2013 | Biomedical and Environmental Sciences2013，26，2： | 12 |
| 2 | Removal of adhesive dusts from flue gas using corona discharges with spraying water显示文摘Effective removal of adhesive and fine dusts from flue gas is very difficult. A new method of electrostatic precipitation of the corona discharges with spraying water(CDSW) was introduced. A new electrode configuration and the circulation spraying of water were employed in the method. The efficient electrostatic precipitation for adhesive and fine dusts can be accomplished without any drain water during a long operating period. The fundamental structure, discharge characteristics, mechanism of spraying and precipitation principle of the electrostatic precipitation using CDSW were described and analyzed. The V I characteristics, spraying state, supplying water quantity, influence of temperature and clean of the electrodes were researched in series experiments. The treating effects of circulating spraying using the corona plasma at the same time of electrostatic precipitation were investigated. The fundamental theories and experimental data were proposed, in order to effectively remove the adhesive dusts from flue gas using CDSW in practice. | XU De\|xuan, ZHAO Jian\|wei, DING Yun\|zheng, GE Wei\|li (Department of Environmental Science and Engineering, Northeast Normal University, Changchun 130024, China. | 2003 | Journal of Environmental Sciences2003，15，4： | 11 |
| 3 | Nature:研究鉴定出蛋白Nlrp9b抵抗轮状病毒感染机制显示文摘轮状病毒(rotavirus)是婴儿和儿童罹患肠胃炎和腹泻的一种最为常见的原因,每年导致全世界大约21.5万人死亡。它是高度传染性的和潜在致命性的。这种病毒特异性地感染宿主小肠中的肠上皮细胞,并且已进化出抵抗干扰素和NF-KB信号的策略来躲避免疫系统,这就提出一个问题:其他的宿主因子是否参与肠道粘膜中的抗病毒反应。不过,针对体内(特别是通过NLR炎性体)检测和限制肠道病毒的机制,人们知之甚少。 | Shu Zhu, Zheng Wei, Noah W. Palm, Yi Yang, Hua Yu, Hua-Bing Li, Geng Wang, Xuqiu Lei, Marcel R. de Zoete, Jun Zhao, Yunjiang Zheng, Haiwei Chen, Liang Shan, Richard A. Flavell Siyuan Ding, Ningguo Feng, Harry B. Greenberg Siyuan Ding, Harry B. Greenberg Penghua Wang, Yujiao Zhao Wen Pan, Jun Lu Jun Zhao, Yuval Kluger Kellie A. Jurado, Clara Abraham, Erol Fikrig Erol Fikrig, Richard A. Flavell | 2017 | 现代生物医学进展2017，17，27： | 10 |
| 4 | Explicit classes of permutation polynomials of F_3^(3m)显示文摘Permutation polynomials have been an interesting subject of study for a long time and have applications in many areas of mathematics and engineering. However, only a small number of specific classes of permutation polynomials are known so far. In this paper, six classes of linearized permutation polynomials and six classes of nonlinearized permutation polynomials over F33m are presented. These polynomials have simple shapes, and they are related to planar functions. | DING CunSheng1, XIANG Qing2, YUAN Jin3 & YUAN PingZhi4 1 Department of Computer Science and Engineering, The Hong Kong University of Science and Technology, Clearwater Bay, Kowloon, Hong Kong, China 2 Department of Mathematical Sciences, University of Delaware, Newark, DE 19716, USA 3 Department of Computing, Macquarie University, NSW 2109, Australia 4 School of Mathematics, South China Normal University, Guangzhou 510631, China | 2009 | Science China Mathematics2009，52，4： | 8 |
| 5 | Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death显示文摘 | Lifeng Yuan Linhui Zhai Lili Qian De Huang Yi Ding Handan Xiang Xiaojing Liu J. Will Thompson Juan Liu Yong-Han He Xiao-Qiong Chen Jing Hu Qing-Peng Kong Minjia Tan Xiao-Fan Wang | 2018 | Cell Research2018，28，6： | 7 |
| 6 | NUMERICAL SIMULATION OF FORGING AND SUBSEQUENT HEAT TREATMENT OF A ROD BY A FINITE VOLUME METHOD显示文摘A method to simulate processes of forging and subsequent heat treatment of an axial symmetric rod is formulated in eulerian description and the feasibility is investigated. This method uses finite volume mushes for troching material deformation and an automatically refined facet surface to accurately trace the free surface of the deforming material.In the method,the deforming work piece flows through fixed finite volume meshes using eulerian formulation to describe the conservation laws,Fixed finite volume meshing is particularly suitable for large three-dimensional deformation such as forging because remeshing techniques are not required, which are commonly considered to be the main bottelencek in the ssimulations of large defromation by using the finite element method,By means of this finite volume method, an approach has been developed in the framework of 'metallo-thermo-mechanics' to simulate metallic structure, temperature and stress/strain coupled in the heat treatment process.In a first step of simulation, the heat treatment solver is limited in small deformation hypothesis,and un- coupled with forging. The material is considered as elastic-plastic and takes into account of strain, strain rate and temperature effects on the yield stress.Heat generation due to deformation,heat con- duction and thermal stress are considered.Temperature - dependent phase transformation,stress-in- duced phase transformation,latent heat,transformation stress and strain are included.These ap- proaches are implemented into the commerical commercial computer program MSC/SuperForge and a verification example with experimental date is given as comparison. | P. R. Ding D. Y. Ju T. Lnouc and E. de Vries( 1) MSC Japan Ltd., Osaka,Japan 2) Saitama Institute of Technology,Saitama,Japan 3) Kyoto Universily, Kyoto, Japan 4) MacNeal - Schwendler (E. D. C. ) B. V., Gouda, The Netherlands) | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，1： | 6 |
| 7 | Direct laser writing of volumetric gradient index lenses and waveguides显示文摘Direct laser writing(DLW)has been shown to render 3D polymeric optical components,including lenses,beam expanders,and mirrors,with submicrometer precision.However,these printed structures are limited to the refractive index and dispersive properties of the photopolymer.Here,we present the subsurface controllable refractive index via beam exposure(SCRIBE)method,a lithographic approach that enables the tuning of the refractive index over a range of greater than 0.3 by performing DLW inside photoresist-filled nanoporous silicon and silica scaffolds.Adjusting the laser exposure during printing enables 3D submicron control of the polymer infilling and thus the refractive index and chromatic dispersion.Combining SCRIBE’s unprecedented index range and 3D writing accuracy has realized the world’s smallest(15μm diameter)spherical Luneburg lens operating at visible wavelengths.SCRIBE’s ability to tune the chromatic dispersion alongside the refractive index was leveraged to render achromatic doublets in a single printing step,eliminating the need for multiple photoresins and writing sequences.SCRIBE also has the potential to form multicomponent optics by cascading optical elements within a scaffold.As a demonstration,stacked focusing structures that generate photonic nanojets were fabricated inside porous silicon.Finally,an all-pass ring resonator was coupled to a subsurface 3D waveguide.The measured quality factor of 4600 at 1550 nm suggests the possibility of compact photonic systems with optical interconnects that traverse multiple planes.SCRIBE is uniquely suited for constructing such photonic integrated circuits due to its ability to integrate multiple optical components,including lenses and waveguides,without additional printed supports. | Christian R.Ocier Corey A.Richards Daniel A.Bacon-Brown Qing Ding Raman Kumar Tanner J.Garcia Jorik van de Groep Jung-Hwan Song Austin J.Cyphersmith Andrew Rhode Andrea N.Perry Alexander J.Littlefield Jinlong Zhu Dajie Xie Haibo Gao Jonah F.Messinger Mark L.Brongersma Kimani C.Toussaint Jr Lynford L.Goddard Paul V.Braun | 2020 | Light(Science & Applications)2020，9，1： | 6 |
| 8 | Preparation of Mg-Li alloys by electrolysis in molten salt at low temperature显示文摘A new technology for preparation of low cost Mg-Li alloys was studied. The alloys were prepared by electrolysis in molten LiCl-KCl (weight ratio is 1:1) electrolyte with Mg rod severing as the consumed cathode. Main factors that affect current efficiency were investigated, and optimal electrolysis parameters were obtained. Mg-Li alloys with low lithium content (about 25%) were prepared by the unique method of a higher post-thermal treatment temperature after electrolysis at low temperature. The results showed that the electrolysis can be carried out at low temperature, which resulted in reducing preparation cost due to energy saving.The new technology for the preparation of Mg-Li alloy by electrolysis in molten salt was proved to be feasible. | Mi Lin Zhang Yong De Yan Zhi Yao Hou Lu An Fan Zeng Chen Ding Xiang Tang | 2007 | Chinese Chemical Letters2007，18，3： | 5 |
| 9 | Streptozotocin-induced expression of Ngn3 and Pax4 in neonatal rat pancreatic α-cells显示文摘AIM:To investigate the mechanism behind β-cell regeneration in neonatal rat pancreas treated with streptozotocin (STZ).METHODS:Neonatal Sprague Dawley rats were intraperitoneally injected with 70mg/kg STZ.Body weight,pancreas weight and blood glucose were recorded every two days after the treatment.To identify the expression and location of transcription factors in the rat pancreas,double immunofluorescent staining was performed using antibodies to specific cell markers and transcription factors.RESULTS:Expression of Neurogenin 3 (Ngn3),a marker for endocrine precursor cells,was observed by immunofluorescence in a few β-cells and many α-cells.The expression reached a peak 12 d after treatment.Pax4,a transcription factor that lies downstream of Ngn3 and plays an important role in β-cell differentiation,was also expressed in the α-cells of STZ-treated rats.We did not observe significant changes in Nkx6.1,which is essential for β-cell maturation in the treated rats.CONCLUSION:α-cells dedifferentiated into endocrine precursor cells and acquired the ability to dedifferentiate in the neonatal rat pancreas after STZ treatment. | Xiao-Di Liang Yuan-Yuan Guo Ming Sun Ying Ding Ning Wang Li Yuan Wei De | 2011 | World Journal of Gastroenterology2011，17，23： | 5 |
| 10 | In vitro and In vivo Evaluation of the Developed PLGA/HAp/Zein Scaffolds for Bone-Cartilage Interface Regeneration显示文摘Objective To investigate the effect of electronspun PLGA/HAp/Zein scaffolds on the repair of cartilage defects. Methods The PLGA/HAp/Zein composite scaffolds were fabricated by electrospinning method. The physiochemical properties and biocompatibility of the scaffolds were separately characterized by scanning electron microscope(SEM), transmission electron microscope(TEM), and fourier transform infrared spectroscopy(FTIR), human umbilical cord mesenchymal stem cells(h UC-MSCs) culture and animal experiments. Results The prepared PLGA/HAp/Zein scaffolds showed fibrous structure with homogenous distribution. h UC-MSCs could attach to and grow well on PLGA/HAp/Zein scaffolds, and there was no significant difference between cell proliferation on scaffolds and that without scaffolds(P>0.05). The PLGA/HAp/Zein scaffolds possessed excellent ability to promote in vivo cartilage formation. Moreover, there was a large amount of immature chondrocytes and matrix with cartilage lacuna on PLGA/HAp/Zein scaffolds. Conclusion The data suggest that the PLGA/HAp/Zein scaffolds possess good biocompatibility, which are anticipated to be potentially applied in cartilage tissue engineering and reconstruction. | LIN Yong Xin DING Zhi Yong ZHOU Xiao Bin LI Si Tao XIE De Ming LI Zhi Zhong SUN Guo Dong | 2015 | Biomedical and Environmental Sciences2015，28，1： | 5 |
| 11 | Recognition Interactions of Metal-complexing Imprinted Polymer显示文摘Molecularly imprinted polymer, exhibiting considerable enantioselectivity for L-mandelic acid, was prepared using metal coordination-chelation interaction. By evaluating the recognition characteristics in the chromatographic mode, the recognition interactions were proposed: specific and nonspecific metal coordination-chelation interaction and hydrophobic interaction were responsible for substrate binding on metal-complexing imprinted polymer; while the selective recognition only came from specific metal coordination-chelation interaction and specific hydrophobic interaction. | Liu, Y Ding, GS De Wang, J | 2005 | Chinese Chemical Letters2005，16，6： | 5 |
| 12 | Antiparkinsonian treatment for depression in Parkinson's disease: Are selective serotonin reuptake inhibitors recommended?显示文摘Depression is a frequent comorbid syndrome in Parkinson's disease. It is a difficult symptom to manage, as patients continuously receive antiparkinsonian medication and may also have to be treated for the amelioration of the side-effects of antiparkinsonian therapy. The first-line treatment for depression in Parkinson's disease is the use of selective serotonin reuptake inhibitors(SSRIs). The clinical efficacy of these medications in patients with Parkinson's disease is questionable. In fact, based on their mechanism of action, which requires at least a functional serotonergic system, it is predicted that SSRIs will have lower efficacy in patients with Parkinson's disease. Here, we consider the mechanism of action of SSRIs in the context of Parkinson's disease by investigating the fall in the levels of serotonergic markers and the inhibitory outcomes of antiparkinsonian treatment on serotonergic nerve activity. Because certain classes of antidepressant drugs are widely available, it is necessary to perform translational research to address different strategies used to manage depression in Parkinson's disease. | Philippe De Deurwaerdère Yuqiang Ding | 2016 | Translational Neuroscience and Clinics2016，2，2： | 4 |
| 13 | Sex-specific and Dose-response Relationship between the Incidence of Gallstones and Components of the Metabolic Syndrome in Jinchang Cohort:A Prospective Study显示文摘Gallstones is a very common gastrointestinal disease,involving the formation of masses in the gall bladder or biliary tract,due to abnormally high concentrations of cholesterol or bilirubin in the bile[1].There is a 10%–20%prevalence of gallstones worldwide,and>20%of patients with gallstones show clinical symptoms,implying a substantial disease burden[1]. | YANG Jing Li HUANG Jun Jun CHENG Ning ZHANG De Sheng LIU Si Min HUANG Wen Ya LI Na HUANG Pei Yao DING Jiao LIU Nian BAO Kai Fang DING Jie CHEN Xiao Liang ZHENG Tong Zhang BAI Ya Na | 2020 | Biomedical and Environmental Sciences2020，33，8： | 4 |
| 14 | An Effective On-line Surface Particles Inspection Instrument for Large Aperture Optical Element显示文摘Surface particles growing in large aperture optical element(LAOE) have significant impact on LAOE s stable operation.It is a challenge for the online system to inspect the particles with long working distance, enough precision and high efficiency because of the system constraints. In this paper, an effective and portable inspection instrument is designed based on dark-field imaging principle.A Nikon lens and an industrial high definition(HD) camera are selected to construct the vision system to inspect particles of microns size spreading over hundreds of millimeters. Using two motors and other mechanical structure, the system can realize auto-focus and image rectification functions. The line light sources are installed on both sides of the LAOE in a sealed box while the vision system is portable and working outside the box. An adaptive binarization method is proposed to process the captured dark-field image.The distribution of particles on the LAOE s surface is investigated. Because of the high resolution of the captured image, the SSE2 instructions optimization method is used to reduce the time cost of the algorithm. Experiments show that the instrument can inspect LAOE effectively and accurately. | Wen-Dong Ding Zheng-Tao Zhang Da-Peng Zhang De Xu Hai-Bing Lv Xin-Xiang Miao Guo-Rui Zhou Hao Liu | 2017 | International Journal of Automation and computing2017，14，4： | 4 |
| 15 | Complement C3a activates osteoclasts by regulating the PI3K/PDK1/SGK3 pathway in patients with multiple myeloma显示文摘Objective:Myeloma bone disease(MBD)is the most common complication of multiple myeloma(MM).Our previous study showed that the serum levels of C3/C4 in MM patients were significantly positively correlated with the severity of bone disease.However,the mechanism of C3 a/C4 a in osteoclasts MM patients remains unclear.Methods:The formation and function of osteoclasts were analyzed after adding C3 a/C4 a in vitro.RNA-seq analysis was used to screen the potential pathways affecting osteoclasts,and the results were verified by Western blot,q RT-PCR,and pathway inhibitors.Results:The osteoclast area per view induced by 1μg/m L(mean±SD:50.828±12.984%)and 10μg/m L(53.663±12.685%)of C3 a was significantly increased compared to the control group(0μg/m L)(34.635±8.916%)(P<0.001 and P<0.001,respectively).The relative m RNA expressions of genes,OSCAR/TRAP/RANKL/cathepsin K,induced by 1μg/m L(median:5.041,3.726,1.638,and 4.752,respectively)and 10μg/m L(median:5.140,3.702,2.250,and 5.172,respectively)of C3 a was significantly increased compared to the control group(median:3.137,2.004,0.573,and 2.257,respectively)(1μg/m L P=0.001,P=0.003,P<0.001,and P=0.008,respectively;10μg/m L:P<0.001,P=0.019,P<0.001,and P=0.002,respectively).The absorption areas of the osteoclast resorption pits per view induced by 1μg/m L(mean±SD:51.464±11.983%)and 10μg/m L(50.219±12.067%)of C3 a was also significantly increased(33.845±8.331%)(P<0.001 and P<0.001,respectively)compared to the control.There was no difference between the C4 a and control groups.RNA-seq analysis showed that C3 a promoted the proliferation of osteoclasts using the phosphoinositide 3-kinase(PI3 K)signaling pathway.The relative expressions of PIK3 CA/phosphoinositide dependent kinase-1(PDK1)/serum and glucocorticoid inducible protein kinases(SGK3)genes and PI3 K/PDK1/p-SGK3 protein in the C3 a group were significantly higher than in the control group.The activation role of C3 a in osteoclasts of MM patients was reduced by the SGK inhibitor(EMD638683).Conclusions:C3 a activated osteoclasts by regulating the PI3 K/PDK1/SGK3 pathways in MM patients,which was reduced using a SGK inhibitor.Overall,our results identified potential therapeutic targets and strategies for MBD patients。 | Fengjuan Jiang Hui Liu Fengping Peng Zhaoyun Liu Kai Ding Jia Song Lijuan Li Jin Chen Qing Shao Siyang Yan Kim De Veirman Karin Vanderkerken Rong Fu | 2021 | Cancer Biology & Medicine2021，18，3： | 3 |
| 16 | Crystal structure of the Egol-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORCl signaling显示文摘 | Katie Powis Tianlong Zhang Nicolas Panchaud Rong Wang Claudio De Virgilio Jianping Ding | 2015 | Cell Research2015，25，9： | 3 |
| 17 | Potentiometric detection of polyions based on functionalized magnetic nanopaiticles显示文摘A novel potentiometric detection strategy based on functionalized magnetic nanoparticles has been developed for rapid and sensitive sensing of polyions.Highly dispersed magnetic nanoparticles coated with ion exchanger and plasticizer could promote an in situ cooperative ion-pairing interaction between the ion exchanger and the polyion analyte in sample solution by dramatically reducing the mass-transfer distance.With applying a magnetic field,the nanoparticles can be attached to the surface of ion exchanger free polymeric membrane.The observed potential signals are related to the polyion concentrations.The proposed polymeric membrane electrode exhibits a linear relationship between the greatest potential response slope(dE/dt) and the logarithm of protamine concentration in the range of 0.05-5μg/mL with a lower detection limit of 0.033μg/mL. | De An Song Rong Ning Liang Rui Ming Zhang Jia Wang Ding Jun Zhang Wei Qin | 2010 | Chinese Chemical Letters2010，21，11： | 2 |
| 18 | Do current anti-cyberloafing disciplinary practices have a replica in research findings?: A study of the effects of coercive strategies on workplace Internet misuse显示文摘 | Pablo Zoghbi Manrique de Lara Domingo Verano Tacoronte Jyh-Ming Ting Ding | 2006 | Internet Research2006，，4： | 2 |
| 19 | XIDM: A Common Data Model Based on XML显示文摘Integration between file systems and multidatabase systems is a necessary approach to support data sharing from distributed and heterogeneous data sources. We first analyses problems about data integration between file systems and multidatabase systems. Then, A common data model named XIDM(XML\|based Integrating Dada Model), which is XML oriented, is presented. XIDM bases on a series of XML standards, especially XML Schema, and can well describe semistructured data. So XIDM is powerfully practicable and multipurpose. | Li Bing 1, Lu Zheng ding 1, Peng De chun 2 1.College of Computer Science & Technology,Huazhong University of Science & Technology,Wuhan 430074, China 2.State Key Laboratory of Software Engineering, Wuhan University,Wuhan 430072, China | 2001 | Wuhan University Journal of Natural Sciences2001，6，Z1： | 2 |
| 20 | Photo-thermoelectric effect induced electricity in stretchable graphene-polymer nanocomposites for ultrasensitive strain sensing显示文摘Stretchable strain sensors play an increasingly important role in artificial intelligent devices.However,high-performanee strain sensors havebeen slowly developed owing to the harsh requirement of self-powered function,long cycle life and high resolution.Here,we report aself-powered stretchable graphene-ecoflex composite strain sensor based on photo-thermoelectric(PTE)effect induced electricity.Thedevice exhibits a high strain sensitivity of-0.056 In(nA)/%with strains ranged from 0%to 20%under 980 nm light illumination,where thestrain sensitivity can be found to in crease with in creasi ng light inte nsity.The strain sensor maintains outstanding dyn amic stability un derperiodic strains ranged from 0 to 100%in 100 cycles.The sensing resolution can be as high as 0.5%with both the response and recovery timeof less than 0.6 s.It can precisely monitor human joint motions and stretchable strains by implanting the device in pork. | Ding Zhang Yiding Song Lu Ping Suwen Xu De Yang Yuanhao Wang Ya Yang | 2019 | Nano Research2019，12，12： | 2 |
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