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| 1 | A randomized,double-blind,placebo-controlled trial assessing the efficacy and safety of tegaserod in patients from China with chronic constipation显示文摘AIM: To evaluate the efficacy and safety of tegaserod, 6 mg twice daily (b.i.d.), in men and women with chronic constipation (CC) from China. METHODS: This was a multicenter, double-blind, placebo-controlled study. Following a 2-wk treatment-free baseline period, patients were randomized to receive either tegaserod (6 mg b.i.d.) or placebo (b.i.d.) for 4 wk. An analysis of covariance with repeated measures was used to determine the overall effect of treatment for the primary efficacy variable; the change from baseline in the number of complete spontaneous bowel movements (CSBMs) during the 4-wk treatment period. Secondary efficacy endpoints included other measures of response in terms of CSBMs, and patients’ daily and weekly assessment of bowel habits. Safety was also assessed, based on the incidence and severity of adverse events (AEs).RESULTS: A total of 607 patients were randomized to receive either tegaserod (n = 304) or placebo (n = 303). Tegaserod treatment resulted in a rapid and significant increase from baseline in the adjusted mean number of CSBMs per week over wk 1-4 compared with placebo (1.39 vs 0.91, P = 0.0002). A statistically significant difference in favor of tegaserod was also observed for a mean increase ≥ 1 CSBM/wk over wk 1-4 (47.7% vs 35.0%, tegaserod vs placebo, respectively, P = 0.0018) and for the absolute number of ≥ 3 CSBMs/wk over wk 1-4 (25.0% vs 14.5%, tegaserod vs placebo, respectively, P = 0.0021). Improvements in other symptoms of CC were also seen in the tegaserod group, including improved stool form and reduced straining. In addition, more patients in the tegaserod group reported satisfactory relief from their constipation symptoms. The frequency and severity of AEs was comparable between tegaserod and placebo groups, with the exception of a greater incidence of diarrhea in patients receiving tegaserod (3.6%) compared with placebo (1.7%).CONCLUSION: Tegaserod treatment improved multiple symptoms of CC and was associated with a favorable safety profile. | San-Ren Lin Mei-Yun Ke Jin-Yan Luo Yao-Zong Yuan Ji-Yao Wang Shelley diTommaso Verena Walter Jiaqing Huang | 2007 | World Journal of Gastroenterology2007，13，5： | 7 |
| 2 | The development and initial validation of the Social and Emotional Loneliness Scale 显示文摘 | Ditommaso E Spinner B | 1993 | Personality and Indi- vidual Differences1993，14，1： | 1 |
| 3 | European Journal of Plant Pathology显示文摘 | Vogelgsang S Watson A K DiTommaso A | 1998 | 104(4) : 253 - 2621998，104，4： | 1 |
| 4 | Weed composition and cover after three years of soil fertility management in the cen- tral Brazilian Amazon: Compost, fertilizer, manure and char- coal applications 显示文摘 | Major J Steiner C Ditommaso A | 2005 | Weed Biology and Management2005，5，： | 1 |
| 5 | Climate change and weed adaptation: can evolution of invasive plant lead to greater range expansion than forecasted显示文摘 | Clements D R Ditommaso A | 2011 | Weed Research2011，51，3： | 1 |
| 6 | Effects of arbuscular mycorrhizal fungi on the exotic invasive vine pale swallow-wort (Vincetoxicum rossicum)显示文摘 | Smith L L DiTommaso A Lehmann J Greipsson S | 2008 | Invasive Plant Science and Management2008，1，2： | 1 |
| 7 | Resource manipulations in natural vegetation: A review显示文摘 | DiTommaso Av Aarssen L W | | Vegetatiov l aSs0，84，： | 1 |
| 8 | A novel device for the collection, storage, transport, and delivery of beneficial insects, and its application to Ophraella communa (Coleoptera: Chrysomelidae)显示文摘 | Teshler M P Demovici S A DiTommaso A | 2004 | Biocontrol Science and Technology2004，14，4： | 1 |
| 9 | Impact of sodium hypochlorite concentration and exposure period on germination and radi- cle elongation of three annual weed species 显示文摘 | Ditommaso A Nurse R E | 2004 | Seed Sci- ence and Technology2004，32，2： | 1 |
| 10 | Basement Mem- branes in Development and Disease 显示文摘 | Fenny Wiradjaja Tia DiTommaso and Ian Smyth | 2010 | Birth Defects Research (Part C)2010，90，： | 1 |
| 11 | Analysis of non-stationary structural systems by using a band-variable filter 显示文摘 | Ditommaso R Mucciarelli M Ponzo F C | 2012 | Bulletin of Earthquake Engineering2012，10，3： | 1 |
| 12 | Resource manipulations in natural vegetation: A review 显示文摘 | DiTommaso A Aarssen L W | 1989 | Vegetation1989，84，： | 1 |
| 13 | At-tachment styles,social skills and loneliness in young adults显示文摘 | DiTommaso E Brannen-McNulty C Ross L | 2003 | Personality and Individual Difference2003，，2： | 1 |
| 14 | Foreignbodiesaspiratedinchildren:roleofbronchoscopy显示文摘 | DivisiD DiTommasoS GarramoneM etal | 2007 | ThoracCardiovascSurg2007，55，4： | 1 |
| 15 | Weed composition and cover after three years of soil fertility management in the cen- tral Brazilian Amazon: Compost, fertilizer, manure and charcoal applications 显示文摘 | Julie Major Christoph Steiner Antonio Ditommaso New- ton P S Falclo Johannes Lehmann | 2005 | Weed Biology and Management2005，5，2： | 1 |
| 16 | Modulation of haemostatic function and prevention of experimental thrombosis by red wine in rats:a role for increased nitric oxide production显示文摘 | Aiello L DiTommaso D | 1999 | Br J Pharmacol1999，127，： | 1 |
| 17 | Weed composi- tion and cover after three years of soil fertility manage- ment in the central Brazilian Amazon: Compost, fertiliz- er,manure and charcoal applications 显示文摘 | Major J Steiner C Ditommaso A | 2005 | Weed Biology Managemem2005，5，： | 1 |
| 18 | Molecular Basis for Differential Metabolic Responses to Monosulfuron in Three Nitrogen-Fixing Cyanobacteria显示文摘 | Shen J Y DiTommaso A Shen M Q | 2009 | Weed Science2009，57，2： | 1 |
| 19 | Weed composition and cover after three years of soil fertility management in the central Brazilian Amazon: Compost, fertilizer, manure and charcoal applications 显示文摘 | Major J Steiner C Ditommaso A | 2005 | Weed Biol Manage2005，5，： | 1 |
| 20 | Molecular Basis for Differential Metabolic Responses to Monosulfuron in Three Nitrogen-Fixing Cyanobacteria显示文摘 | Shen J Y DiTommaso A Shen M Q | 2009 | Weed Science2009，57，2： | 1 |
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