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| 1 | Frailty is independently associated with increased hospitalisation days in patients on the liver transplant waitlist显示文摘AIM To investigate the impact of physical frailty on risk of hospitalisation in cirrhotic patients on the liver transplant waitlist.METHODS Cirrhotics listed for liver transplantation at a single centre underwent frailty assessments using the Fried Frailty Index, consisting of grip strength, gait speed, exhaustion, weight loss, and physical activity. Clinical and biochemical data including MELD score as collected at the time of assessment. The primary outcome was number of hospitalised days per year; secondary outcomes included incidence of infection. Univariable and multivariable analysis was performed using negative binomial regression to associate baseline parameters including frailty with clinical outcomes and estimated incidence rate ratios(IRR). RESULTS Of 587 cirrhotics, 64% were male, median age(interquartile range) was 60(53-64) years and MELD score was 15(12-18). Median Fried Frailty Index was 2(1-3); 31.6% were classified as frail(fried frailty ≥ 3). During 12 mo of follow-up, 43% required at least 1hospitalisation; 38% of which involved major infection.107/184(58%) frail and 142/399(36%) non-frail patients were hospitalised at least once(P < 0.001). In univariable analysis, Fried Frailty Index was associated with total hospitalisation days per year(IRR = 1.51,95%CI: 1.28-1.77; P ≤ 0.001), which remained significant on multivariable analysis after adjustment for MELD, albumin, and gender(IRR for frailty of 1.21,95%CI: 1.02-1.44; P = 0.03). Incidence of infection was not influenced by frailty.CONCLUSION In cirrhotics on the liver transplant waitlist, physical frailty is a significant predictor of hospitalisation and total hospitalised days per year, independent of liver disease severity. | Marie Sinclair Eduard Poltavskiy Jennifer L Dodge Jennifer C Lai | 2017 | World Journal of Gastroenterology2017，23，5： | 11 |
| 2 | Social cognitvie biases and deficits in aggressive boys显示文摘 | Frame C L | 1982 | Child Development1982，，53： | 1 |
| 3 | Evaluation of ethylene inhibitors for postharvest treatment of Gypsophila paniculata L显示文摘 | Newman J P Dodge L L Reid M S | | 0，，01： | 1 |
| 4 | Mapping the protein phosphatase-2B anchoring site on AKAP79, binding and inhibition of phosphatase activity are mediated by residues 315-360 显示文摘 | Dell'Acqua M L Dodge K L Tavalin S J | 2002 | J Biol Chem2002，277，48： | 1 |
| 5 | Simulated low-g sloshing inspherical, ellipsoidal, and cylindrical tanks显示文摘 | Dodge F T Garza L R | 1970 | Journal of Spacecraft and Rockets1970，7，2： | 1 |
| 6 | Intrathoracic spatial location of specified coronary segments on the normal human heart 显示文摘 | Dodge J T Brown B G Bolson E L | 1988 | Circulation1988，78，5： | 1 |
| 7 | Hypothyroidism and cognition : preliminary evidence for a specific defect in memory 显示文摘 | Burmeister L A Ganguli M Dodge H H | 2001 | Thyroid2001，11，12： | 1 |
| 8 | Phosphorylation of serine 1105 by protein kinase A inhibits phospholipase Cβ3 stimulation by Galphaq 显示文摘 | Yue C Dodge K L Weber G | 1998 | J Biol Chem1998，273，18： | 1 |
| 9 | Follow-up after primary therapy for endometrial cancer: a systematic review 显示文摘 | Fung-Kee-Fung M Dodge J Elit L | 2006 | Gynecol Oncol2006，101，： | 1 |
| 10 | Ascorbic acid and rates of cognitive decline in Alzheimer's disease显示文摘 | Bowman G L Dodge H Frei B | 2009 | J Alzbeimer''s Dis2009，16，1： | 1 |
| 11 | Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation,chromosomal instability, and spontaneous immortalization r显示文摘 | Dodge JE Okano M Dick F et a l | 2005 | J Biol Chem2005，280，17： | 1 |
| 12 | Environmental estrogens : effects on cholesterol lowering and bone in the ovariectomized rat 显示文摘 | DODGE J A GLASEBROOK A L MAGGEE D E | 1996 | J Steroid Biochem Mol Biol1996，59，： | 1 |
| 13 | A model for anionic surfactant sorption 显示文摘 | Toro D M Dodge L J Hand V C | 1990 | Environ Sci Technol1990，24，7： | 1 |
| 14 | Identification of regulatory elements in the Plasmodium falciparum genome 显示文摘 | Militello KT Dodge M Bethke L | 2004 | Mol Biochem Parasitol2004，134，1： | 1 |
| 15 | Follow-up after pri- mary therapy for endometrial cancer: a systematic review 显示文摘 | Fung-Kee-Fung M Dodge J Elit L | 2006 | Gynecol Oncol2006，101，： | 1 |
| 16 | Clinical findings through hospital dis- charge,a comparison between intravenous tissue plasminogen activator and intravenous streptokinase,Thrombolysis in myocardial infarction (TIMI) trial,Circulation显示文摘 | Chesebro J H Knatterud G Roberts R Borer J Cohen L S Dalen J Dodge H T Francis C K Hillis D Ludbrook P et al Phase I | | 0，，： | 1 |
| 17 | Inactivation of Lrp5 in osteocytes reduces Young's modulus and responsiveness to the mechanical loading 显示文摘 | Zhao L Shim JW Dodge TR | 2013 | Bone2013，54，： | 1 |
| 18 | Application and comparison of classification algorithms for recognition of Alzheimer's disease in electrical brain activity (EEG)显示文摘 | Lehmann C Koenig T Jelic V Prichep L John RE Wahlund LO Dodge Y Dierks T | | 0，，： | 1 |
| 19 | Hypothyroidism and cognition : preliminary evidence for a specific defect in memory 显示文摘 | Burmeister L A Ganguli M Dodge H H | 2001 | Thyroid2001，11，12： | 1 |
| 20 | Cyberspatial proximity metrics: reconceptualizing distance in the global urban system显示文摘 | Zook M Devriendt L Dodge M | 2011 | Journal of Urban Technology2011，18，1： | 1 |
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