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| 1 | Clinical outcomes and ergonomics analysis of three laparoscopic techniques for Hirschsprung's disease显示文摘AIM: To report the clinical outcomes and ergonomics analysis of three laparoscopic approaches in the management of Hirschsprung's disease(HD).METHODS: There were 90 pediatric patients(63 boys, 27 girls; mean age: 3.6 ± 2.7 mo; range: 1.0-90.2 mo) who underwent laparoscopic endorectal pull-through Soave procedures for short- and long-segment HD in our hospital. Three laparoscopic approaches were used: conventional laparoscopic pull-through(CLP) in 30 patients between 2009 and 2013, single-incision laparoscopic pull-through(SILP) in 28 patients between 2010 and 2013, and hybrid single-incision laparoscopic pull-through(H-SILP) in 32 patients between 2011 and 2013. We applied the hybrid version of the single-incision approach in 2011 to preserve the cosmetic advantage of SILP and the ergonomic advantage of CLP. We retrospectively analyzed the clinical data, cosmetic results, and ergonomics of these three approaches to have a better understanding of the selection of one approach over another. RESULTS: The CLP, SILP, and H-SILP groups were similar in regard to age, sex, transition zone, blood loss, hospital stay, and intraoperative complications. Early and late postoperative results were not different, with equal daily defecation frequency and postoperative complications. No conversion to open technique was needed and none of the patients had recurrent constipation. With proper training, the ergonomics challenges were overcome and similar operative times were registered for the general operative time in the patients < 1 year of age and the short-segment HD patients. However, significantly shorter operative times were registered compared to SILP for patients > 1 year of age(CLP and H-SILP: 120 ± 15 min and 119 ± 12 min, respectively, vs 140 ± 7 min; P < 0.05) and for long-segment HD patients(152 ± 3.5 min and 154 ± 3.6 min, respectively, vs 176 ± 2.3 min; P < 0.05). The best cosmetic result was registered with the SILP(scarless), followed by the H-SILP(near scarless appearance) and the CLP(visible scars) procedures. CONCLUSION: Based on the results, we believed that the laparoscopic approach should be selected according to the age, transition zone, and desired cosmetic result. | Tajammool Hussein Aubdoollah Kang Li Xi Zhang Shuai Li Li Yang Hai-Yan Lei Ponnie Robertlee Dolo Xian-Cai Xiang Guo-Qing Cao Guo-Bin Wang Shao-Tao Tang | 2015 | World Journal of Gastroenterology2015，21，29： | 5 |
| 2 | High prevalence of epilepsy in onchocerciasis endemic health areas in Democratic Republic of the Congo显示文摘Background:A high prevalence of epilepsy has been observed in many onchocerciasis endemic regions.This study is to estimate the prevalence of active epilepsy and exposure to Onchocerca volvulus infection in a rural population in Ituri province,Democratic Republic of Congo.Methods:In August 2016,a community-based cross-sectional study was conducted in an onchocerciasis endemic area in the rural health zone of Logo,Ituri Province.Households within two neighbouring health areas were randomly sampled.To identify persons with epilepsy,a three-stage approach was used.In the first stage,all individuals of the selected households were screened for epilepsy by non-medical field workers using a validated 5-item questionnaire.In the second and third stage,suspected cases of epilepsy were examined by non-specialist medical doctors,and by a neurologist,respectively.A case of epilepsy was defined according to the 2014 International League Against Epilepsy(ILAE)guidelines.Exposure to O.volvulus was assessed by testing for IgG4 antibodies to an O.volvulus antigen(OV16 Rapid Test,)in individuals aged 3 years and older.Results:Out of 1389 participants included in the survey,64 were considered to have active epilepsy(prevalence 4.6%)(95%confidence interval[CI]:3.6-5.8).The highest age-specific epilepsy prevalence estimate was observed in those aged 20 to 29 years(8.2%).Median age of epilepsy onset was 10 years,with a peak incidence of epilepsy in the 10 to 15 year-old age group.OV16 test results were available for 912 participants,of whom 30.5%(95%CI,27.6-33.6)tested positive.The prevalence of OV16 positivity in a village ranged from 8.6 to 68.0%.After adjusting for age,gender and ivermectin use,a significant association between exposure to onchocerciasis and epilepsy was observed(adjusted odds ratio=3.19,95%CI:1.63-5.64)(P<0.001).Conclusions:A high prevalence of epilepsy and a significant association between epilepsy and exposure to O.volvulus were observed in the population in Ituri province,Democratic Republic of Congo.There is an urgent need to implement a CDTI programme and to scale up an epilepsy treatment and care programme. | Evy Lenaerts Michel Mandro Deby Mukendi Patrick Suykerbuyk Housseini Dolo Deogratias Wonya’Rossi Françoise Ngave Chellafe Ensoy-Musoro Anne Laudisoit An Hotterbeekx Robert Colebunders | 2018 | Infectious Diseases of Poverty2018，7，1： | 5 |
| 3 | Emergence agitation in pediatric anesthesia:current features显示文摘 | Silva LM Braz LG Módolo NS | 2008 | J Pediatr(Rio J)2008，84，2： | 1 |
| 4 | Community perceptions of epilepsy and its treatment in an onchocerciasis endemic region in Ituri,Democratic Republic of Congo显示文摘Background:A recent study in the Logo and Rethy health zones in the Ituri Province in the Democratic Republic of Congo(DRC)reported that the majority of the persons with epilepsy(PWE)had not been treated with anti-epileptic medication(AEM)or had stopped treatment.Prior to the implementation of an epilepsy treatment programme in these health zones,this study investigated the perceptions and experiences regarding epilepsy and its treatment amongst community leaders,PWE and/or their families,traditional healers and health professionals.Methods:A total of 14 focus group discussions(FGD)and 39 semi-structured interviews(SSI)were conducted with PWE and/or their family members,community leaders,traditional healers,and health professionals in the Logo and Rethy health zones during February 2-19,2017.Results:In the two health zones,the clinical signs of convulsive epilepsy were recognized by community members.However,a variety of misconceptions about epilepsy were identified including the beliefs that epilepsy is a family-related condition,a contagious disease,is transmitted by insects,saliva or by touching a person of the same sex during seizures,or is caused by evil spirits and witchcraft.The role of traditional healers in spreading these beliefs was revealed.The study also reported sexual abuse on PWE,stigmatisation of PWE and loss of productivity of PWE and their families.Some PWE had been using AEM and traditional treatment but were not convinced about the efficacy of these treatment options.The lack of training of health providers about epilepsy care,financial barriers in obtaining AEM,and the shortage of AEM at primary health facilities were revealed.As remedies,the community requested access to a decentralized center for epilepsy treatment.They also proposed using churches and community health workers as communication channels for information about epilepsy.Conclusions:Clinical signs of convulsive epilepsy were recognized by the community in the Logo and Rethy health zones but many misconceptions about epilepsy were identified.A comprehensive community-based epilepsy treatment programme with an affordable uninterrupted AEM supply needs to be established.Such a programme should address stigma,misconceptions,sexual abuse and foster the rehabilitation of PWE to alleviate poverty. | Housseini Dolo Michel Mandro Deogratias Wonya’Rossi Francoise Ngave Jessica Fraeyman Joseph NSiewe Patrick Suykerbuyk Robert Colebunders | 2018 | Infectious Diseases of Poverty2018，7，1： | 1 |
| 5 | Filariasis attenuates anemia and proinflammatory responses associated with clinical malaria:a matched prospective study in children and young adults显示文摘 | Dolo H Coulibaly YI Dembele B | 2012 | PLoS Negl Trop Dis2012，6，11： | 1 |
| 6 | Analysis of parame ters that influence the amplitude of the ESR/ala nine signal after irradiation 显示文摘 | DOLO J M FEAUGAS V | 2005 | Applied Radia tion and Isotopes2005，62，： | 1 |
| 7 | Biological validation of a sample preparation method for ER-CALUX bioanalysis of estrogenic activity in sediment using mixtures of xeno-estrogens显示文摘 | Zako D Soto AM Dolo L | 2003 | Environ Health Perspect2003，111，3： | 1 |
| 8 | Plasminogen activator system modulates invasive capacity and proliferation in prostatic tumor cells 显示文摘 | Festuccia C Dolo V Gueerra F | 1998 | Clin Exp Metastasis1998，16，6： | 1 |
| 9 | Matrix-degrading proteinases are shed in membrane vesicles by ovarian cancer in vivo and in vitro 显示文摘 | Dolo V D Ascenzo S Violoni S | 1999 | Clin Exp Metastasis1999，17，： | 1 |
| 10 | Tyrosine kinase inhibitor CEP-701 blocks the NTRK1/NGF receptor and limits the invasive capability of prostate cancer cel s in vitro显示文摘 | Festuccia C Muzi P Gravina GL Millimaggi D Speca S Dolo V | 2007 | Int J Oncol2007，30，1： | 1 |
| 11 | Enrichment and loealizafian of ganglioside G (D3) and caveolirr-lin shed tumor cell membrane vesicles显示文摘 | DOLO V LI R DILLINGER M | 2000 | Biochim Biophys Acta2000，1486，23： | 1 |
| 12 | Nature polymorphism in the thrombospoondin related adhesive protein of Plasmodium falciparum显示文摘 | Dolo A Hackford IR | 1998 | Am J Trop Med Hyg1998，58，： | 1 |
| 13 | Plasminogen Activator System Modulates Invasive Capacity and Proliferation in Prostatic Tumor Cells显示文摘 | Festuccia C Dolo V Guerra F | | 0，，： | 1 |
| 14 | Thrombospondin related adhesive protein(TRAP), a potential malaria vaccine candidate显示文摘 | Modiano D Doumbo O | 1999 | Parassitologia1999，41，： | 1 |
| 15 | Enrichment and localization of ganglioside G(D3)and caveolirr-lin shed tumor cell membrane vesicles显示文摘 | Dolo V Li R Dillinger M | 2000 | Biochim Biophys Acta2000，1486，23： | 1 |
| 16 | Emergence agitation in pediatric anesthesia:current features显示文摘 | Silva LM Braz LG Módolo NS | | 0，，02： | 1 |
| 17 | Emergence agitation in pediatric anesthesia: current features显示文摘 | Silva LM Braz LG Módolo NS | 2008 | J Pediatr2008，84，2： | 1 |
| 18 | Microvesicles as potential o- varian cancer biomarkers 显示文摘 | Giusti I D'Ascenzo S Dolo V | 2013 | Biomed Res Int2013，2013，70： | 1 |
| 19 | Plasminogen activator system modulates invasive capacity and proliferation in prostatic tumor cells显示文摘 | Dolo V Gueerra F | 1998 | Clin Exp Metastasis1998，16，6： | 1 |
| 20 | On the interest and the limits of using combined ESR/U-series model in the case of very late uranium uptake显示文摘 | Falgueres C Bahain J-J Dolo J M | 2007 | Quaternary Geochronology2007，2，14： | 1 |
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