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| 1 | Clinical application of concentrated bone marrow aspirate in orthopaedics:A systematic review显示文摘AIM To examine the evidence behind the use of concentrated bone marrow aspirate(c BMA) in cartilage, bone, and tendon repair; establish proof of concept for the use of cB MA in these biologic environments; and provide the level and quality of evidence substantiating the use of cB MA in the clinical setting.METHODS We conducted a systematic review according to PRISMA guidelines. EMBASE, MEDLINE, and Web of Knowledge databases were screened for the use of cB MA in the repair of cartilage, bone, and tendon repair. We extracted data on tissue type, cB MA preparation, cB MA concentration, study methods, outcomes, and level of evidence and reported the results in tables and text.RESULTS A total of 36 studies met inclusion/exclusion criteria and were included in this review. Thirty-one of 36(86%) studies reported the method of centrifugation and preparation of cB MA with 15(42%) studies reporting either a cell concentration or an increase from baseline. Variation of c BMA application was seen amongst the studies evaluated. Twenty-one of 36(58%) were level of evidence Ⅳ, 12/36(33%) were level of evidence Ⅲ, and 3/36(8%) were level of evidence Ⅱ. Studies evaluated full thickness chondral lesions(7 studies), osteochondral lesions(10 studies), osteoarthritis(5 studies), nonunion or fracture(9 studies), or tendon injuries(5 studies). Significant clinical improvement with the presence of hyaline-like values and lower incidence of fibrocartilage on T2 mapping was found in patients receiving cB MA in the treatment of cartilaginous lesions. Bone consolidation and time to bone union was improved in patients receiving cB MA. Enhanced healingrates, improved quality of the repair surface on ultrasound and magnetic resonance imaging, and a decreased risk of re-rupture was demonstrated in patients receiving cB MA as an adjunctive treatment in tendon repair. CONCLUSION The current literature demonstrates the potential benefits of utilizing c BMA for the repair of cartilaginous lesions, bony defects, and tendon injuries in the clinical setting. This study also demonstrates discrepancies between the literature with regards to various methods of centrifugation, variable cell count concentrations, and lack of standardized outcome measures. Future studies should attempt to examine the integral factors necessary for tissue regeneration and renewal including stem cells, growth factors and a biologic scaffold. | Arianna L Gianakos Li Sun Jay N Patel Donald M Adams Frank A Liporace | 2017 | World Journal of Orthopedics2017，8，6： | 5 |
| 2 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010，，10： | 3 |
| 3 | Acute surgical emergencies in inflammatory bowel disease显示文摘 | Dale F Berg Anil M Bahadursingh Donald L Kaminski Walter E Longo | 2002 | The American Journal of Surgery2002，，： | 2 |
| 4 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007，，10： | 2 |
| 5 | Exploratory bioavailability and pharmacokinetic studies of sulphadime-thoxine and ormetoprim in the penaeid shrimp, Penaeus vannamei 显示文摘 | Eric D P Donald V L Nicholas M | 1995 | Aquaculture1995，130，： | 1 |
| 6 | The Quality of Life (QOL) Research Movement: Past, Present, and Future显示文摘 | Sirgy M A C michalos A L Ferriss R Easterlin Donald Patrick William Pavot | 2006 | Social Indicators Research2006，76，： | 1 |
| 7 | The clinical and genetic features of COPD-asthma overlap syndrome显示文摘 | Harding M Cho M Mc Donald M L | 2014 | Eur Respir J2014，44，2： | 1 |
| 8 | Prediction trends in rate parameters for self-diffusion on FCC metal surfaces显示文摘 | Agrawal Paras M Rice Besty M Thompson Donald L | 2002 | Surface Science2002，515，： | 1 |
| 9 | The capsaicinoid: their separation, synthesis and mutagenicith 显示文摘 | Peter M G Donald L N Pam J R | 1988 | J Org Chem1988，53，5： | 1 |
| 10 | 查看详情显示文摘 | Elaine M T Donald J L J John H.L Debbie A M Peter B F Karen B | | 0，，： | 1 |
| 11 | Mental stress induces transient endothelial dysfunction in humans 显示文摘 | Ghiadoni L Donald AE Cropley M | 2000 | Circulation2000，102，8： | 1 |
| 12 | Reaction and Transport of Arsenic in Soils: Equilibrium and Kinetic Modeling显示文摘 | Zhan$ 14 Sel im 14 M Donald L S | 2008 | Advances in Agronomy2008，98，： | 1 |
| 13 | Television and Attitudes Toward Mental Health Issues : Cultivation Analysis and the Third - person Effect 显示文摘 | Donald L Diefenbach M D W | 2007 | Joumal of Community Psychology2007，35，2： | 1 |
| 14 | Electrophilic C-H activation at fCp* Ix}: Ancillary- ligand control of the mechanism of CH activation显示文摘 | DAVIES D L DONALD S M AL- DUAIJ O | 2006 | Journal of the American Chemistry Society2006，128，13： | 1 |
| 15 | Scattering studies of the internal structure of starch granules显示文摘 | Donald A M Kato K L Perry P A | 2001 | Starch2001，53，： | 1 |
| 16 | Investigation of the morphology,viability and mechanical properties of yeast cells in environmental SEM显示文摘 | Ren Y L Donald A M Zhang Z B | 2008 | Scanning2008，30，6： | 1 |
| 17 | Explaining the Premiums Paid for Large Acquisitions:Evidence of CEO Hubris显示文摘 | Hayward L A M Donald C H | 1997 | Adminis- trative Science Quarterly1997，，42： | 1 |
| 18 | Pigs learn what a mirror image represents and use it to obtain information显示文摘 | Donald M Broom Hilana Sena Kiera L Moynihan | 2009 | Animal Behaviour2009，78，5： | 1 |
| 19 | Characterization of the solution conformations of unbound and Tat peptide-bound forms of HIV-1 TAR RNA显示文摘 | Katherine S L Donald M C | 1999 | Biochem1999，38，10： | 1 |
| 20 | Mental stress induces transient endothelial dysfunction in humans 显示文摘 | Ghiadoni L Donald AE Cropley M | 2000 | Circulation2000，102，20： | 1 |
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