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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | 猪的回肠炎及其控制显示文摘 | Jim O Donovan 余春明 | 2002 | 中国畜牧兽医2002，29，4： | 4 |
| 3 | Randomized crossover study comparing efficacy of transnasal endoscopy with that of standard endoscopy to detect Barrett’s esophagus显示文摘 | M. Kareem Shariff Elizabeth L. Bird-Lieberman Maria O'Donovan Zarah Abdullahi Xinxue Liu Jane Blazeby Rebecca Fitzgerald | 2012 | Gastrointestinal Endoscopy2012，，5： | 2 |
| 4 | Cryopreservation of eguine embryos by open pulled straw, cryoloop, or conventional slow cooling methods显示文摘 | Oberstein N O Donovan M K Bruemmer J E | 2001 | Theriogenology2001，55，： | 2 |
| 5 | Mycogenic Silver Nanoparticles From Endophytic Trichoderma atroviride with Antimicrobial Activity显示文摘There is an increasing interest in developing nanoparticles with diverse biologic activities.To this end,we prepared 10 to 15 nm silver nanoparticles(AgNP)from native isolates of Trichoderma atroviride.Within this study,endophytic fungi hosted four medicinal plants in Saint Katherine Protectorate,South Sinai,Egypt have been isolated by surface sterilization technique on four isolation media.Ten species,based on their frequency of occurrence,out of twenty recovered taxa were tested for their capability to synthesize extracellular AgNPs.Trichoderma atroviride hosted Chiliadenus montanus was found to be the best candidate for the production of mycogenic AgNPs among all examined species.The mycosynthesized AgNPs were compared with chemically synthesized and characterized using Ultraviolet-visible(UV-vis)spectroscopy,Raman spectroscopy,X-ray diffraction(XRD)and high-resolution transmission electron microscopy(HRTEM)techniques.The HRTEM result showed the distribution of spherical AgNPs ranging from 10 to 15 nm.Trichoderma atroviride isolate was subjected to sequencing for confirmation of phenotypic identification.The internal transcribed spacer(ITS)1-5.8 s-ITS2 rDNA sequences obtained were compared with those deposited in the GenBank Database and registered with accession number MH283876 in the NCBI Database.Antibacterial,anticandidal and antifungal effects of chemically and mycosynthesized AgNPs were examined at various concentrations in vitro against six pathogenic bacteria and 4 pathogenic fungi by agar well diffusion technique.Standard antibiotics;Gentamicin,Amoxicillin,Clotrimazole,and Nystatin at 5μg/disk were taken as positive controls,while 5%DMSO was used as the negative control.Our data revealed that the application of mycogenic AgNPs at a concentration of 100 ppm resulted in maximum inhibition of pathogenic bacteria and fungi.These data suggest that AgNPs from native isolates of Trichoderma atroviride(MH283876)offer a source of rapid synthesis of eco-friendly,economical biomaterials that show antimicrobial activities. | Ahmed Abdel-Azeem Amr A.Nada Anthonia O’Donovan Vijay Kumar Thakur Amr Elkelish | 2020 | Journal of Renewable Materials2020，8，2： | 2 |
| 6 | Gastric emptying in diabetes: clinical significance and treatment 显示文摘 | Horowitz M O'Donovan D Jones KL | 2002 | Diabet Med2002，19，3： | 1 |
| 7 | Genome-wide analysis of histone modifications by ChiP-on-chip显示文摘 | Huebert D J Kamal M O'Donovan A | 2006 | Methods2006，40，4： | 1 |
| 8 | Recent genomic advances in schizophrenia显示文摘 | Doherty J O'Donovan M Owen M | 2012 | Clin Genet2012，81，2： | 1 |
| 9 | Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia显示文摘 | Masashi Ikeda Yoshio Yamanouchi Yoko Kinoshita Tsuyoshi Kitajima Reiji Yoshimura Shuji Hashimoto Michael C O&rsquor Donovan Jun Nakamura Norio Ozaki Nakao Iwata | 2008 | Pharmacogenomics2008，，10： | 1 |
| 10 | The effect of the nitrification inhibitor dicyandiamide (DCD) on herbage production when applied at different times and rates in the autumn and winter显示文摘 | O'Connor PJ Hennessy D Brophy C O'Donovan M Lynch MB | 2012 | Agricultural Ecosystems & Environment2012，152，： | 1 |
| 11 | Survivin:a promising tumor biomarker显示文摘 | Duffy MJ O'Donovan N Brennan DJ | 2007 | CancerLett2007，249，1： | 1 |
| 12 | Prevalence and outcome of partial remission in depression显示文摘 | Tranter R O'Donovan C Chandarana P | 2002 | J Psychiatry Neurosci2002，27，4： | 1 |
| 13 | Activity of dasatinib with chemotherapy in triple -negative breast cancer cells显示文摘 | Tryfonopoulos D O Donovan N Corkery B | 2009 | J Clin Oncol (Meeting Abstracts)2009，27，14： | 1 |
| 14 | Ambulatory hysteroscopy:evidence-based guide to diagnosis and therapy显示文摘 | Bakour SH Jones SE O'Donovan P | 2006 | Best Pract Res Clin Obstet Gynaecol2006，20，6： | 1 |
| 15 | Idiopathic and diabetic gastroparesis显示文摘 | O'Donovan D Feinle- Bisset C Jones K | 2003 | Curr Treat Options Gastroenterol2003，6，： | 1 |
| 16 | Phosphorus retention and sorption by constructed wetland soils in South- east Ireland显示文摘 | DUNNE E J CULLETON N O'DONOVAN G | 2005 | Water Research2005，39，18： | 1 |
| 17 | Environmental Disclosuresin the Annual Report:Extending the Applicabilitya nd Pred ict ive Power of Leg it imac y Theor y显示文摘 | O’Donovan G | 2002 | Accounting Auditing & Accountability Journal2002，15，3： | 1 |
| 18 | Surface expression of minichromosome maintenance proteins provides a novel method for detecting patients at risk for developing adenocarcinoma in Barrett's esophagus显示文摘 | Sirieix P S O'Donovan M Brown J | 2003 | Clin Cancer Res2003，9，7： | 1 |
| 19 | Solitary fibrous tumor of the orbit显示文摘 | O'Donovan DA Bilbao JM Fazl M | 2002 | J Creniofac Surg2002，13，5： | 1 |
| 20 | Treatment of male infertility:is it effective? Review and Meta-analyses of published randomized controlled trials显示文摘 | O'DONOVAN P A VANDEKERCKHOVE P LILFORD R J | 1993 | Hum Reprod1993，8，8： | 1 |
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