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| 1 | 睾丸后精子成熟,不育与高胆固醇血症显示文摘胆固醇是参与哺乳动物生理活动的重要分子,由于它是固醇类激素合成的通用前体物质,因而对生殖系统尤为重要。胆固醇不仅仅对于配子发生起到重要作用,它也是公认的精子功能的调节分子。胆固醇体内平衡的调节对睾丸后精子的成熟至关重要,胆固醇水平失衡会影响到睾丸后调控事件。代谢性脂质紊乱(血脂异常症)会影响男性的生育能力,但大多数这方面的研究是从内分泌/睾丸的角度进行探讨的,而这篇综述将关注像高胆固醇血症这样的特定血脂异常症在哺乳动物精子的睾丸后成熟过程中的有害影响。 | Marjorie Whitfield Xavier PoUet-Villard Rachel Levy Joel R Drevet Fabrice Saez | 2015 | Asian Journal of Andrology2015，17，5： | 8 |
| 2 | Epididymis cholesterol homeostasis and sperm fertilizing ability显示文摘胆固醇,是类固醇荷尔蒙合成的起点,在性腺的水平特别是女性和男繁殖生理学的一个长已知的调节的人,影响胆固醇穿上 gametogenesis。更少对动态平衡可以在 postgonadic 上有的效果胆固醇被知道繁殖功能。最近,几个数据被报导了显示出 imbalanced 胆固醇层次怎么可以特别地影响精子成熟的 testicular 以后事件导致充分肥沃的男配偶子。这评论将集中于那个方面并且实质上在胆固醇怎么为哺乳动物的 epididymis 和精子的生理学是重要的上集中。 | Fabrice Saez Ouvrier and Joel R Drevet | 2011 | Asian Journal of Andrology2011，13，1： | 7 |
| 3 | A sequence of 28S rRNA-derived small RNAs is enriched in mature sperm and various somatic tissues and possibly associates with inflammation显示文摘 | Chu, Chen Yu, Lu Wu, Bin Ma, Li Gou, Lan-Tao He, Miao Guo, Yunli Li, Zhi-Tong Gao, Wei Shi, Huijuan Liu, Mo-Fang Wang, Hongyan Chen, Charlie Degui Drevet, Joel R. Zhou, Yuchuan Zhang, Yonglian | 2017 | Journal of Molecular Cell Biology2017，9，3： | 6 |
| 4 | The epididymal immune balance:a key to preserving male fertility显示文摘Up to 15%of male in fertility has an immuno logical origi n,either due to repetitive infections or to autoimmune resp on ses mainly affecting the epididymis,prostate,and testis.Clinical observations and epidemiological data clearly contradict the idea that the testis confers immune protection to the whole male genital tract.As a consequenee,the epididymis,in which posttesticular spermatozoa mature and are stored,has raised some in terest in recent years when it comes to its immune mecha nisms.In deed,sperm cells are produced at puberty,long after the establishment of self-toleranee,and they possess unique surface proteins that cannot be recognized as self.These are potential targets of the immune system,with the risk of inducing autoantibodies and consequently male infertility.Epididymal immunity is based on a finely tuned equilibrium between efficient immune responses to pathogens and strong tolerance to sperm cells.These processes rely on incompletely described molecules and cell types.This review compiles recent studies focusing on the immune cell types populating the epididymis,and proposes hypothetical models of the organization of epididymal immunity with a special emphasis on the immune response,while also discussing important aspects of the epididymal immune regulation such as tolerance and tumour control. | Allison Voisin Fabrice Saez Joel R Drevet Rachel Guiton | 2019 | Asian Journal of Andrology2019，21，6： | 4 |
| 5 | Serum vitamin D content is associated with semen|parameters and serum testosterone levels in men显示文摘The present study aimed to evaluate the influence of serum vitamin D levels on semen quality and testosterone levels.This is a crosssectional study conducted at Androscience,Science and Innovation Center in Andrology and High-Complex Clinical and Andrology Laboratory in Sao Paulo,Brazil,with 508 male patients,aged 18-60 years,from 2007 to 2017.Seminal parameters and serum sexual hormones were correlated with serum vitamin D concentrations in 260 men selected by strict selection criteria.Patients were divided into normozoospermic group(NZG,n=124)and a group with seminal abnormalities(SAG,n=136).Evaluation included complete physical examination,past medical history,habits and lifestyle factors,two complete seminal analysis with sperm functional tests,serum levels of 25-hydroxy-vitamin D_(3)(25(OH)VD_(3)),total and free testosterone,luteinizing hormone(LH),follicle-stimulating hormone(FSH),sex hormone-binding globulin(SHBG),total cholesterol,homeostatic model assessment of insulin resistance(HOMA-IR)index,and karyotype.The mean concentration of 25(OH)VD_(3)was significantly lower in the SAG(P<0.001)and positively correlated with all baseline seminal parameters and total testosterone levels.In addition,serum vitamin D_(3)concentration was found to be positively correlated with sperm concentration(β=2.103;P<0.001),total number of spermatozoa with progressive motility(β=2.069;P=0.003),total number of motile spermatozoa(β=2.571;P=0.015),and strict morphology(β=0.056;P=0.006),regardless of other variables.This is the first comparative study to address the issue of serum vitamin D_(3)content between normozoospermic patients and those with sperm abnormalities.It clearly demonstrates a direct and positive relationship between serum vitamin D level and overall semen quality,male reproductive potential,and testosterone levels. | Inari M Ciccone Elaine MF Costa Juliana R Pariz Thiago A Teixeira Joel R Drevet Parviz Gharagozloo Robert J Aitken Jorge Hallak | 2021 | Asian Journal of Andrology2021，23，1： | 2 |
| 6 | Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice显示文摘The mammalian epididymis not only plays a fun dame ntal role in the maturati on of spermatozoa,but also provides protecti on agai nst various stressors.The foremost among these is the threat posed by oxidative stress,which arises from an imbalance in reactive oxygen species and can elicit damage to cellular lipids,proteins,and nucleic acids.In mice,the risk of oxidative damage to spermatozoa is mitigated through the expression and secretion of glutathione peroxidase 5(GPX5)as a major luminal scavenger in the proximal caput epididymidal segment.Accordingly,the loss of GPX5^-/-mediated protection leads to impaired DNA integrity in the spermatozoa of aged Gpx57 mice.To explore the underlying mechanism,we have conducted transcriptomic analysis of caput epididymidal epithelial cells from aged(13 months old)Gpx5^-/-m mice.This analysis revealed the dysregulation of several thousand epididymal mRNA transcripts,in eluding the downregulation of a subgroup of piRNA pathway gen es,in aged Gpx5^-/-mice.In agreeme nt with these fin dings,we also observed the loss of piRNAs,which potentially bind to the P-element-induced wimpy testis(PlWI)-like proteins PIWIL1 and PIWIL2.The absence of these piRNAs was correlated with the elevated mRNA levels of their putative gene targets in the caput epididymidis of Gpx5^-/-mice.Importantly,the oxidative stress response genes tend to have more targeting piRNAs,and many of them were among the top increased genes upon the loss of GPX5^-/-.Taken together,our findings suggest the existence of a previously uncharacterized somatic piRNA pathway in the mammalian epididymis and its possible invoIvement in the aging and oxidative stress-mediated responses. | Chen Chu Lu Yu Joelle Henry-Berger Yan-Fei Ru Ayhan Kocer Alexandre Champroux Zhi-Tong Li Miao He Sheng-Song Xie Wu-Bin Ma Min-Jie Ni Zi-Mei Ni Yun-Li Guo Zhao-Liang Fei Lan-Tao Gou Qiang Liu Samanta Sharma Yu Zhou Mo-Fang Liu Charlie Degui Chen Andrew L Eamens Brett Nixon Yu-Chuan Zhou Joel R Drevet Yong-Lian Zhang | 2020 | Asian Journal of Andrology2020，22，6： | 2 |
| 7 | Functional anatomical abnormalities in limbic and prefrontal cortical structures in mahor depression显示文摘 | Drevets W C | 2000 | Prog Brain Res2000，126，： | 1 |
| 8 | Isolation and characterization of a cDNA clone encoding a putative white spruce glycine-ricb RNA binding protein显示文摘 | Richard S Drevet C Jouanin L | 1999 | Gene1999，240，2： | 1 |
| 9 | Listeria moncytogenes infection and activation of human brain microvascular endothelial cells显示文摘 | Wilson SL Drevets DA | 1998 | J Infect Dis1998，178，： | 1 |
| 10 | Subgenual prefrontal cortex abnormalities in mood disorders显示文摘 | Drevets WC Price JL Simpson JRJ | 1997 | Nature1997，386，： | 1 |
| 11 | Low glial numbers in the amygdala in major depressive disorder显示文摘 | Bowley MP Drevets WC Ongur D | 2002 | Biol Psychiatry2002，52，5： | 1 |
| 12 | Neurocircuitry of mood disorders显示文摘 | Price JL Drevets WC | | Neuropsy- ebepharmaeology0，35，1： | 1 |
| 13 | Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippoeampal and amygdalar volumes in subjects with major depressive disorder 显示文摘 | Savitz J Drevets WC Smith CM | 2015 | Neuropsychopharmaeology2015，40，2： | 1 |
| 14 | Antidepressant efficacy of the antimuscarinic drug scopolamine:A randomized,placebo- controlled clinical trial显示文摘 | FUREY M L DREVETS W C | 2006 | Arch Gen Psychiatry2006，63，： | 1 |
| 15 | A functional anatomical study of unipolar depression 显示文摘 | Drevets WC Videen TO Price JL | 1992 | I Neurosci1992，12，： | 1 |
| 16 | Neuroimaging studies of mood discords 显示文摘 | Drevets WC | 2000 | Boil Psychiafry2000，48，： | 1 |
| 17 | Subgenual prefrontal cortexabnormalities in mood disorders显示文摘 | Drevets WC Price JL Simpson JR | 1997 | Nature1997，386，： | 1 |
| 18 | Volumetric reduction in left subgenual prefrontal cortex in early onset depression显示文摘 | Botteron KN Raichle ME Drevets WC | 2002 | Biol Psychiatry2002，51，： | 1 |
| 19 | Neuroimaging studies of bipolar de- pression : functional neuropathology, treatment effects, and predictors of clinical response显示文摘 | Ketter TA Drevets WC | 2002 | Clinical Neuro Res2002，2，34： | 1 |
| 20 | Brain structural and functional abnormalities in mood disorders:implications for neurocircuitry models of depression显示文摘 | Drevets WC Price JL Furey ML | 2008 | Brain Struct Funct2008，213，12： | 1 |
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