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| 1 | 卵巢上皮癌的组织起源及其分子生物学特性显示文摘卵巢癌的致死率高居妇科恶性肿瘤之首。卵巢上皮癌是最常见的恶性卵巢肿瘤,而人们对它的起源一直存在争议。近年来分子生物学的发展将卵巢癌的研究带入了新的水平。本文主要通过概述卵巢上皮癌起源的主要学说,分子生物学标志物在卵巢癌中的最新应用,以及基因工程动物模型的建立等问题,来进一步了解卵巢癌的发病机制。这对该病的早期诊断以及探索新的治疗方案有重要意义。 | 刘影 DUBEAU Louis | 2015 | 分子诊断与治疗杂志2015，7，2： | 7 |
| 2 | The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation显示文摘MRE11/RAD50/NBS1 建筑群是很快招募到 DNA 双海滨裂缝(DSB ) 的主要传感器。MRE11 被知道是由在它的 glycine-arginine-rich (长嘴硬鳞鱼) 以内的 PRMT1 的精氨酸 methylated 主题。在这研究,我们报导在 GAR 主题与离氨酸代替精氨酸并且产生 MRE11 缺乏 methylated 精氨酸的 RK 蛋白质。Mre11 RK/RK 老鼠对 γ 过分敏感;照耀(红外) 和从这些老鼠的房间显示了房间周期检查点缺点和染色体不稳定性。而且, Mre11 RK/RK MEF 展出了在 RPA 和 RAD51 的招募表明缺点和缺陷到损坏地点的 ATR/CHK1。M RK 形成的 RN 建筑群并且对 DNA 损坏并且通常的地点局部性响应红外激活 ATM 小径。M RK RN 建筑群在为响应红外在 vivo 观察的损害 DNA 结束切除术和 ATR 激活负责的 vitro 展出了 exonuclease 和 DNA 有约束力的缺点。我们的调查结果在 DSB 修理为 MRE11 长嘴硬鳞鱼主题的关键角色提供基因证据,并且在 MRE11 长嘴硬鳞鱼表明在 translational 以后修正之间的一个机械学的连接主题并且 DSB 处理,以及发信号的 ATR/CHK1 检查点。 | Zhenbao Yu Gillian Vogel Yan Coulombe Danielle Dubeau Elizabeth Spehalski Josee Hebert David O Ferguson Jean Yves Masson Stephane Richard | 2012 | Cell Research2012，22，2： | 5 |
| 3 | 脑室周围结节状异位在癫痫发病中的作用 | Aghakhani Y. Kinay D. Gotman J. F. Dubeau 郭俊 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，8： | 2 |
| 4 | Clinical predictors of thiopurine-related adverse events in Crohn's disease显示文摘AIM: To determine the incidence and predictors of thiopurine-related adverse events. METHODS: Subjects with Crohn's disease who were followed in the Alberta Inflammatory Bowel Disease Consortium patient database registry were identified. Retrospective chart review was conducted between August 5th, 2010 and June 1st, 2012. We collected data on: age at diagnosis; sex; disease location and behaviour at time of prescribing thiopurine; perianal fistulising disease at or prior to thiopurine prescription; smoking status at time of thiopurine prescription, use of corticosteroid within 6 mo of diagnosis; dosage, age at onset, and cessation of 5-aminosalicyclic acid(5-ASA); anti-tumour necrosis factor medication exposure and intestinal resection before thiopurine prescription. The primary outcome of interest was the first adverse event that led to discontinuation of the first thiopurine medication used. Logistic regression models were used to associate clinical characteristics with outcomes after adjusting for potential confounders. Risk estimates were presented as odds ratios(OR) with 95% CI. Effect modification by age and sex were explored.RESULTS: Our cohort had a median follow-up duration of 5.8 years [interquartile range(IQR 25th-75th) 2.7-9.1]. Thiopurine therapy was discontinued in 31.3% of patients because of: hypersensitivity reactions(7.1%), acute pancreatitis(6.2%), gastrointestinal intolerance(5.4%), leucopenia(3.7%), hepatotoxicity(3.4%), infection(1.1%) and other reasons(4.3%). A higher incidence of thiopurine withdrawal was observed in patients over the age of 40(39.4%, P = 0.007). A sexby-age interaction(P = 0.04) was observed. Females older than 40 years of age had an increased risk of thiopurine discontinuation due to an adverse event(age above 40 vs age below 40, adjusted OR = 2.8; 95%CI: 1.4-5.6). In contrast, age did not influence thiopurine withdrawal in males(age above 40 vs below 40, adjusted OR = 0.9; 95%CI: 0.4-2.1). Other clinical variables(disease location and phenotype, perianal disease, smoking history, history of intestinal resection and prior 5-ASA or corticosteroid use) were not associated with an increased risk an adverse event leading to therapy cessation. CONCLUSION: Thiopurine withdrawal due to adverse events is commoner in women over the age of 40 at prescription. These findings need to be replicated in other cohorts. | Gordon W Moran Marie-France Dubeau Gilaad G Kaplan Hong Yang Bertus Eksteen Subrata Ghosh Remo Panaccione | 2015 | World Journal of Gastroenterology2015，21，25： | 2 |
| 5 | Neural mechanisms of empathy in humans:A relay from neural systems for imitation to limbic areas 显示文摘 | Carr L Iacoboni M Dubeau M-C Mazziotta JC Lenzi GL | 2003 | Proceedings of the National Academy of Sciences of USA2003，，100： | 1 |
| 6 | Invasive electrographic recording techniques intemporal显示文摘 | Dubeau F Richard S Mclachlan M | 2000 | Can J Neurol Sci2000，27，1： | 1 |
| 7 | Occurrence of scalp-fast oscillations among patients with different spiking rate and their role as epileptogenicity marker 显示文摘 | Melani F Zelmann R Dubeau F | 2013 | Epilepsy Res2013，106，： | 1 |
| 8 | Interictal scalp fast oscillations as a marker of the seizure onset zone显示文摘 | Andrade-Valenca L P Dubeau F Mari F | 2011 | Neurology2011，77，6： | 1 |
| 9 | Automatic detection of fast oscillations(40-200 Hz) in scalp EEG recordings显示文摘 | von-Ellenrieder N Andrade-Valenca L P Dubeau F | 2012 | Clin Neurophysiol2012，123，4： | 1 |
| 10 | Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas 显示文摘 | Carr L Iacoboni M Dubeau MC | 2003 | Proc Natl Aead Sci2003，100，： | 1 |
| 11 | Epitopes recognized by hu- man T lymphocytes in the Rop2 Protein antigen of Toxoplasma tondii 显示文摘 | Saadvedra R Becerril MA Dubeau XC | 2001 | Parasitol Res2001，87，1： | 1 |
| 12 | Carbon and steel microfiber-reinforced cement-based composites for thin repairs显示文摘 | Dubeau S | 1994 | Journal of Materials in Civil Engineering1994，6，1： | 1 |
| 13 | Correspondence between EEG-- fMRI and EEG dipole localisation of interictal discharges in focal epilepsy显示文摘 | Bagshaw AP Kobayashi E Dubeau F | 2006 | Neuroimage2006，2，： | 1 |
| 14 | Telomerase and maliagnant transformation显示文摘 | Yu J Dubeau L | 2002 | Cancer Treat Res2002，107，2： | 1 |
| 15 | Interictal scalp fast oscillations as a marker of the seizure onset zone显示文摘 | Andrade-Valenca L P Dubeau F Mari F | 2011 | Neurology2011，77，6： | 1 |
| 16 | Novel concepts in inflammatory bowel disease 显示文摘 | Moran GW Dubeau MF Kaplan GG | 2014 | Br Med Bull2014，09，： | 1 |
| 17 | Novel concepts in inflammatory bowel disease 显示文摘 | Moran GW Dubeau MF Kaplan GG | 2014 | Br Med Bull2014，109，1： | 1 |
| 18 | Xylanase of Chaetomium cellulolyticum:its nature of production and hydrolytic potential显示文摘 | DUBEAU H CHAHAL D S ISHAQUE M | 1987 | Biotechnol Lett1987，9，： | 1 |
| 19 | Occurrence of scalp-fast oscillations among patients with different spiking rate and their role as epileptogenicity marker显示文摘 | Melani F Zelmann R Dubeau F | 2013 | Epilepsy Res2013，106，3： | 1 |
| 20 | Xylanase of Chaetomium cellulolyticum: Its nature of production and hydrlytic potential显示文摘 | DUBEAU H CHAHAL D S ISHAQUE M | 1987 | Biotechnol Lett1987，，9： | 1 |
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