维普期刊资源整合服务平台（V6.5）

44篇 您的检索式：作者名="E Kalra"

选中清除导出查看参考文献查看引证文献引用追踪共3页首页上一页第1页下一页末页 /3 跳转

	题名	作者	年代	出处	被引量
1	Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis显示文摘AIM To investigate gender-specific liver estrogen receptor(ER) expression in normal subjects and patients with hepatitis C virus(HCV)-related cirrhosis and hepatocellular carcinoma(HCC).METHODS Liver tissues from normal donors and patients diagnosed with HCV-related cirrhosis and HCV-related HCC were obtained from the NIH Liver Tissue and Cell Distribution System. The expression of ER subtypes, ERα and ERβ, were evaluated by Western blotting and real-time RT-PCR. The subcellular distribution of ERα and ERβ was further determined in nuclear and cytoplasmic tissue lysates along with the expression ofinflammatory [activated NF-κB and IκB-kinase(IKK)] and oncogenic(cyclin D1) markers by Western blotting and immunohistochemistry. The expression of ERα and ERβ was correlated with the expression of activated NF-κB, activated IKK and cyclin D1 by Spearman's correlation. RESULTS Both ER subtypes were expressed in normal livers but male livers showed significantly higher expression of ERα than females(P < 0.05). We observed significantly higher m RNA expression of ERα in HCV-related HCC liver tissues as compared to normals(P < 0.05) and ERβ in livers of HCV-related cirrhosis and HCV-related HCC subjects(P < 0.05). At the protein level, there was a significantly higher expression of nuclear ERα in livers of HCV-related HCC patients and nuclear ERβ in HCV-related cirrhosis patients as compared to normals(P < 0.05). Furthermore, we observed a significantly higher expression of phosphorylated NF-κB and cyclin D1 in diseased livers(P < 0.05). There was a positive correlation between the expression of nuclear ER subtypes and nuclear cyclin D1 and a negative correlation between cytoplasmic ER subtypes and cytoplasmic phosphorylated IKK in HCV-related HCC livers. These findings suggest that dysregulated expression of ER subtypes following chronic HCVinfection may contribute to the progression of HCVrelated cirrhosis to HCV-related HCC.CONCLUSION Gender differences were observed in ERα expression in normal livers. Alterations in ER subtype expression observed in diseased livers may influence genderrelated disparity in HCV-related pathogenesis.	Janaki K Iyer Mamta Kalra Anil Kaul Mark E Payton Rashmi Kaul	2017	World Journal of Gastroenterology2017，23，37：	5
2	New Insights Into the Epidemiologic and Clinical Manifestations of Atherosclerotic Renovascular Disease显示文摘	Conlon PJ O'Riordan E Kalra PA	2000	Am J Kidney Dis2000，35，4：	1
3	Resveratrol enhances ultraviolet B induced cell death through nuclear factor-κB pathway in human epidermoid carcinoma A431 cells显示文摘	Roy P Madan E Kalra N	2009	Biochem Biophys Res Com- mun2009，384，2：	1
4	Exon skipping andgene transfer restore dystrophin expression in human inducedpluripotent stem cells-cardiomyocytes harboring DMD mutations显示文摘	Dick E Kalra S Anderson D George V	2013	Stem Cells Dev2013，22，20：	1
5	Lympho- cytic hypophysitis in children:a novel presentation and literature re- view显示文摘	Kalra A A Riel-Romero R M Gonzalez-Toledo E	2011	J Child Neurol2011，26，1：	1
6	Antigen retrieval in fomalin-fixed parafin-embedding tissue: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections显示文摘	Shi S R Key M E Kalra K L	1991	J Histochem Cytochem1991，39，6：	1
7	16-MDCT of the post- traumatic pediatric elbow:optimum parameters and associated radiation dose显示文摘	Chapman V M Kalra M Halpem E	2005	Am J Roentgenol2005，185，3：	1
8	Exon skipping and gene transferrestore dystrophin expression in human induced pluripotent stemcells-cardiomyocytes harboring DMD mutations显示文摘	Dick E Kalra S Anderson D	2013	Stem Cells Dev2013，22，10：	1
9	显示文摘	O'Riordan E Kalra RA etal	2000	Am J Kidney Dis2000，35，：	1
10	Abdominal CT:comparison of adaptive statistical iterative and filtered back projection reconstruction techniques显示文摘	Singh S Kalra M K Hsieh J Licato P E Do S	2010	Radiology2010，257，2：	1
11	Agmatine, a novel hypothalamic amine,stimulates pituitary luteinizing hormone release in vivo and hypothalamic luteinizinghormone-releasing hormone release in vitro显示文摘	Kalra SP Pearson E Sahu A Kalra PS	1995	Neurosci Lett1995，194，3：	1
12	New insights into the epidemiologic and clinical manifestations of atherosclerotic renovascular disease显示文摘	Conion PJ O'Riordan E Kalra PA	2000	Am J Kidney Dis2000，35，：	1
13	Adverse reactions to intravenous iodinated contrast media: a primer for radiologists显示文摘	Namasivayam S Kalra M K Torres W E	2006	Emerg Radiol2006，12，5：	1
14	Antigen retrieval in formalin-fixed, paraffin-embedded tissues an enhancement method for immunohis tochemical staining based on microwave oven heating of tissue sections 显示文摘	Shi S R Key E M Kalra K L	1991	The Journal of Histochemistry and Cytoochemistry1991，，39：	1
15	Lymphocytic hypophysitis in children: a novel presentation and literature review 显示文摘	Kalra AA Riel-Romero RM Gonzalez-Toledo E	2011	J Child Neurol2011，26，1：	1
16	Rhythmic, reciprocal ghrelin and leptin signaling: new insight in the development of obesity显示文摘	Kalra S P Bagnasco M Otukonyong E E	2003	Regulatory Peptides2003，111，：	1
17	Alternative strategies for stroke care: a prospective randomized controlled trial 显示文摘	Kalra L Evans E Perez I	2000	Lancet2000，356，：	1
18	Generalized synchronization of spatiotemporal chaos in liquid crystal spatial light modulator显示文摘	Rogers E A Kalra R Schrol R D	2004	Phys Rev Lett2004，93，84：	1
19	Neuropeptidergic characterization of the leptin receptor mutated obese Koletsky rat 显示文摘	Keen Rhinehart E Kalra SP	2004	Regul Pept2004，119，：	1
20	New insights into the epidemiologie and clinical manifestations of atherosclerotic renovascular disease显示文摘	Conlon PJ O Riordan E Kalra PA	2000	Am J Kidney Dis2000，35，：	1

返回顶部每页显示：

共3页首页上一页第1页下一页末页 /3 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示