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| 1 | Surgical treatment for liver cancer显示文摘Primary liver cancer is amongst the commonest tumors worldwide,particularly in parts of the developing world,and is increasing in incidence. Over the past three decades,surgical hepatic resection has evolved from a high risk,resource intensive procedure with limited application,to a safe and commonly performed operation with a range of indications. This article reviews the approach to surgical resection for malignancies such as hepatocellular cancer,metastatic liver de-posits and neuroendocrine tumors. Survival data after resection is also reviewed,as well as indications for curative resection. | Nicole C Tsim Adam E Frampton Nagy A Habib Long R Jiao | 2010 | World Journal of Gastroenterology2010，16，8： | 12 |
| 2 | Anti-inflammatory pathways and alcoholic liver disease: Role of an adiponectin/interleukin-10/heme oxygenase-1 pathway显示文摘The development of alcoholic liver disease (ALD) is a complex process involving both the parenchymal and non-parenchymal cells in the liver. Enhanced inflammation in the liver during ethanol exposure is an important contributor to injury. Kupffer cells, the resident macrophages in liver, are particularly critical to the onset of ethanol-induced liver injury. Chronic ethanol exposure sensitizes Kupffer cells to activation by lipopolysaccharide via Toll-like receptor 4. This sensitization enhances production of inflammatory mediators, such as tumor necrosis factor-α and reactive oxygen species, that contribute to hepatocyte dysfunction, necrosis, apoptosis, and fibrosis. Impaired resolution of the inflammatory process probably also contributes to ALD. The resolution of inflammation is an active, highly coordinated response that can potentially be manipulated via therapeutic interventions to treat chronic inflammatory diseases. Recent studies have identif ied an adiponectin/interleukin-10/heme oxygenase-1 (HO-1) pathway that is profoundly effective in dampening the enhanced activation of innate immune responses in primary cultures of Kupffer cells, as well as in an in vivo mouse model of chronic ethanol feeding. Importantly, induction of HO-1 also reduces ethanol-induced hepatocellular apoptosis in this in vivo model. Based on these data, we hypothesize that the development of therapeutic agents to regulate HO-1 and its downstream targets could be useful in enhancing the resolution of inflammation during ALD and preventing progression of early stages of liver injury. | Palash Mandal Michele T Pritchard Laura E Nagy | 2010 | World Journal of Gastroenterology2010，16，11： | 11 |
| 3 | Exploring the role of molecular biomarkers as a potential weapon against gastric cancer: a review of the literature显示文摘Gastric cancer(GC) is a global health problem and a major cause of cancer-related death with high recurrence rates ranging from 25% to 40% for GC patients staging Ⅱ-Ⅳ. Unfortunately, while the majority of GC patients usually present with advanced tumor stage; there is still limited evidence-based therapeutic options. Current approach to GC management consists mainly of; endoscopy followed by, gastrectomy and chemotherapy or chemo-radiotherapy. Recent studies in GC have confirmed that it is a heterogeneous disease. Many molecular characterization studies have been performed in GC. Recent discoveries of the molecular pathways underlying the disease have opened the door to more personalized treatment and better predictable outcome. The identification of molecular markers is a useful tool for clinical managementin GC patients, assisting in diagnosis, evaluation of response to treatment and development of novel therapeutic modalities. While chemotherapeutic agents have certain physiological effects on the tumor cells, the prediction of the response is different from one type of tumor to the other. The specificity of molecular biomarkers is a principal feature driving their application in anticancer therapies. Here we are trying to focus on the role of molecular pathways of GC and well-established molecular markers that can guide the therapeutic management. | Marwa Matboli Sarah El-Nakeep Nourhan Hossam Alaa Habieb Ahmed EM Azazy Ali E Ebrahim Ziad Nagy Omar Abdel-Rahman | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 4 | Improvement of a large analytical model using test data显示文摘 | Berman A Nagy E J | 1983 | AIAA J1983，21，8： | 2 |
| 5 | Inverse Gas Chromatography Used to Study Lubricating Oil Oxidation Mechanism via Changes in Kovats and Flory-Huggins Retention Parameters显示文摘Inverse gas chromatographic technique(IGC) was attempted as a new approach to follow the chem-ical changes that occur during lubricating base oil oxidation.Three groups of the oxidized base oils were pre-pared at different oxygen flow rates,periods and temperatures according to IP48method.The corrected reten-tion volumes(VR) were calculated for a series of selected test solutes possessing different functional groups onthe oxidized base oils used as stationary phases.Kovats retention index(I),Flory-Huggins interaction parame-ter(κ1∞,2),and partial molar free energy of solution(ΔGL∞),were calculated for the given test solutes fromtheirVR.The relationships between theIvalues and the oxidation variables were plotted and discussed.Theobtained results were confirmed by potentiometric titration.The study reveals that the magnitudes of variationofI,κ1∞,2orΔG∞Lretention parameters depend on the oxidation degree of the base oil.Large differences be-tween theIvalues permit discrimination between the different oxidation steps.Key words: inverse gas chromatography(IGC);oxidation;lubricating base oil;Kovats retention | MOSTAFA Nagy E EISSA Elham A | 2006 | 色谱2006，24，3： | 2 |
| 6 | A Short Amino-Terminal Part of Arabidopsis Phytochrome A Induces Constitutive Photomorphogenic Response显示文摘Phytochrome A (phyA ) 是在 Arabidopsis thaliana 察觉到的 far-red 光的主导的光敏电阻器。phyA 在发信号的变白的幼苗,和导致光的 phyA 的细胞质在高水平积累被一个复杂规章的网络调停。这包括光 -- 并且进在 vivo 的原子核的本国的 phyA 的 FHY1/FHL 蛋白质依赖者 translocation。phyA (PHYA406 ) 的短 N 终端碎片对 phenocopy 足够,这也被显示出在 vitro 的这个高度调整的细胞的过程。为了测试这 N 终端的生物活动,在 planta phyA 碎裂,我们生产了表示 PHYA406YFP 的转基因的 phyA-201 植物(黄荧光灯蛋白质) DD, PHYA406YFPDDNLS (原子本地化信号) ,和 PHYA406YFPDDNES (原子出口信号) 熔化蛋白质。这里,我们报导 PHYA406YFPDD 被进口进原子核,而 PHYA406YFPDDNLS 和 PHYA406YFPDDNES 显示期望的组成的本地化模式,这进程部分是轻依赖者的。我们的结果证明这些截断的 phyA 蛋白质是轻马厩的,当局部性时,他们在他们的原子核,和两个都不触发组成的象 photomorphogenic 一样回答导致合适的 phyA 发信号。我们证明在 vitro 并且在 vivo PHYA406, Pfr 和 Pr 绑 COP1, photomorphogenesis 的一个一般抑压者,并且在原子身体与它共同本地化。因此,我们断定在 planta,截断的 PHYA406 蛋白质以一种光无关的方式在原子核使 COP1 失去活性。 | Andra's Viczia'n E'va Ada'm Iris Wolf Ja'nos Bindics Stefan Kircher Marc Heijde Roman Ulm Eberhard Scha'fer Ferenc Nagy | 2012 | Molecular Plant2012，5，3： | 2 |
| 7 | NT-brain natriuretic peptide levels in pleural fluid distinguish between pteural transudates and exudates显示文摘 | Tomcsanyi J Nagy E Somloi M | 2004 | Eur J Heart Fail2004，6，6： | 1 |
| 8 | Transgingival lag- screw osteosynthesis of alveolar process fracture显示文摘 | Nyarady Z Orsi E Nagy K | 2010 | Int J oral Maxillofac Surg2010，39，8： | 1 |
| 9 | Angiogenesis in pituitary adenomas and the normal pituitary gland显示文摘 | Turner H E Nagy Z Gatter K C | 2000 | J Clin Endocrinol Metab2000，85，3： | 1 |
| 10 | Characteristics of the genome of goose parvovirus 显示文摘 | Zadori Z Judith E Nagy J | 1994 | Avian Path1994，23，2： | 1 |
| 11 | Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis显示文摘 | NAGY J A VASILE E FENG D | 2002 | J Exp Med2002，196，11： | 1 |
| 12 | Construction and characterization of recombinant porcine adenovirus serotype 5 expressing the transmissiblegastroenteritis virus spike gene 显示文摘 | Tuboly T Nagy E | 2001 | J Gen Virol2001，82，1： | 1 |
| 13 | Immunotherapy of the sl2 -5murine lymphorma with natural killer cells and tamoxifen or toremifene显示文摘 | Baral E Nagy E Kangas L | 1997 | Anticancer Res1997，17，1： | 1 |
| 14 | Accumulation of amino acid substitutions promotes irreversible structural changes in the hemagglutinin of human influenza AH3 virus during evolution显示文摘 | Nakajima K Nobusawa E Nagy A | 2005 | J Virol2005，79，： | 1 |
| 15 | Decreased accessibility and lack of activation of ErbB2 in JIMT-1,a herceptin-resistant,MUC4-expressing breast cancer cell line显示文摘 | Nagy P Friedlander E Tanner M | | 0，，02： | 1 |
| 16 | In ovo delivery of Toll- like receptor 2 ligand,lipoteichoic acid induces pro-inflammato- ry mediators reducing post-hatch infectious laryngotracheitis virus infection显示文摘 | Thapa S Nagy E Abdul-Careem MF | 2015 | Vet Immunol Immunopathol2015，164，34： | 1 |
| 17 | Thrombosis risk in systemic lupus erythematosus:the role of thrombophilic risk factors 显示文摘 | Sallai KK Nagy E Bodo I | 2007 | Scand J Rheumatol2007，36，3： | 1 |
| 18 | Mutation scanning of the p53 tumor suppressor gene in renal and liver transplant patients in Hungary 显示文摘 | Sarvary E Nagy P Benjamin A Szoke M Remport A Jansen J | 2005 | Transpl Proc2005，37，： | 1 |
| 19 | Embryonic stem cells aloneare able to support fetal development in the mouse显示文摘 | Nagy A Gozea E | 1990 | Development1990，110，： | 1 |
| 20 | Supression of hemin - media- ted oxidation of low-density lipoprotein and subsequent endothelial reactions by hydrogen sulfide ( H ( 2 ) S ) 显示文摘 | Jeney V Kom6di E Nagy E | 2009 | Free Radic Biol Med2009，46，5： | 1 |
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