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| 1 | Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome显示文摘AIM: To determine whether Lactobacillus casei strain Shirota (Yakult ) can alter small intestinal bacterial overgrowth (SIBO), as tested by the lactulose breath test, and whether this is associated with changes in symptoms in irritable bowel syndrome (IBS). METHODS: 18 patients with IBS (Rome Ⅱ criteria), who showed an early rise in breath hydrogen with lactulose (ERBHAL), consumed 65 mL of Yakult daily for 6 wk. Lactulose breath test was repeated at the end of the treatment period. Symptoms were recorded daily using a 10 cm visual analogue scale. RESULTS: 14 patients completed the study, 9 (64%) had reversal of ERBHAL, with the median time of f irst rise in breath hydrogen increasing from 45 to 75 min (P = 0.03). There was no signifi cant improvement in the symptom score with probiotic therapy, except for wind (P=0.04). Patients commencing with at least moderate symptoms and who no longer had ERBHAL at the end of treatment, showed improvement in the overall symptoms scores [median fi nal score 5.3 (IQR3.9-5.9), 55% reduction; n=6] to a greater extent than those who had had persisting ERBHAL [final score 6.9 (5.0-7.0), 12% reduction; n = 5; P = 0.18]. CONCLUSION: Yakult is effective in altering fermentation patterns in the small bowel, consistent with reducing SIBO. The loss of ERBHAL was associated with reduced symptoms. The true interpretation of these fi ndings awaits a randomised, controlled trial. | Jacqueline S Barrett Kim EK Canale Richard B Gearry Peter M Irving Peter R Gibson | 2008 | World Journal of Gastroenterology2008，14，32： | 16 |
| 2 | High performance InP/InGaAs heterostructure bipolar transistors grown by metalorganic vapor phase epitaxy显示文摘 | Nottenburg R N Chen Y K Tanbun- Ek T | 1989 | Appl Phys Lett1989，55，： | 2 |
| 3 | Improved detection of renal pathologic features on multiphasic helical CT compared with IVU in patients presenting with microscopic hematuria显示文摘 | Lang EK Macchia RJ Thomas R | 2003 | Urology2003，61，3： | 2 |
| 4 | ABC1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation显示文摘 | Wellington CL Walker EK Suarez A Kwok A Bissada N Singaraja R | 2002 | Lab invest2002，82，3： | 1 |
| 5 | Plastic slip distribution in two-phase laminate microstructures,Dislocation-based vs显示文摘 | Forest S Sedláek R | | 0，，： | 1 |
| 6 | Improvingresectability of hepatic colorectal metastases : expert consensusstatement 显示文摘 | Abdalla EK Adam R Bilchik AJ | 2006 | Ann Surg Oncol2006，13，： | 1 |
| 7 | Evaluation of enrofloxacin treatment program against Mycoplasma gaIlisepticum infection in broilers显示文摘 | Barbour EK Hamadeh S Talhouk R | 1998 | Prey Vet Med1998，35，2： | 1 |
| 8 | Intravitreal injection of dispase causes retinal hemorrhages in rabbit and human eyes显示文摘 | Jorge R Oyamaguchi EK Cardillo JA | 2003 | Curr Eye Res2003，26，2： | 1 |
| 9 | Placental site trophoblastic tumor显示文摘 | Ajithkumar TV Abraham EK Rejnishkumar R | 2003 | Obstet Gynecol Surv2003，58，： | 1 |
| 10 | Improved accuracy ofbum wound assessment using laser Doppler 显示文摘 | Yeong EK Mann R Goldberg M | 1996 | J Trauma1996，40，11： | 1 |
| 11 | Effects of passive upper arm exercise on range of motion, muscle strength, and muscle spas- ticity in hemiplegic patients with cerebral vascular disease 显示文摘 | Shin DS Song R Shin EK | 2012 | J Korean Acad Nurs2012，42，6： | 1 |
| 12 | Prevalence of rheumatoid arthritis in persons 60 years of age and older in the United States: effect of different methods of case classification显示文摘 | Rasch EK Hirsch R Paulose-Ram R | 2003 | Arthritis Rheum2003，48，4： | 1 |
| 13 | Spatial analysis of human granulocytic ehrilichiosis near Lyme,Connecticut显示文摘 | Meek JI Heimer R | 2002 | Emerg Infect Dis2002，8，9： | 1 |
| 14 | Familial form of arrhythmogenic right ventricular cardiomyopathy 显示文摘 | Wlodarska EK Konka M Kepski R | 2004 | Kardiol Pol2004，60，1： | 1 |
| 15 | Prevalence of rheumatoid arthritis in persons 60 years of age and older in the United States: ef- fect of different methods of case classification 显示文摘 | Rasch EK Hirsch R Paulose-Ram R | 2003 | Arthritis Rheum2003，48，： | 1 |
| 16 | Phase Ⅰ and pharmacodynamic study of the topoisomerase I-inhibitor topotecan in patients with refractory aucte leukemia显示文摘 | Rowinsky EK Adjiei R Donehower RC | 1994 | J Clin Oncol1994，12，： | 1 |
| 17 | QIIME allows analysis of high-throughput community sequencing data 显示文摘 | Caporaso JG Kuczynski J Stombaugh J Bittinger K Bushman FD Costello EK Fierer N Pena AG Goodrich JK Gordon JI Huttley GA Kelley ST Knights D Koenig JE Ley RE Lozupone CA Mcdonald D Muegge BD Pirrung M Reeder J Sevinsky JR Tumbaugh PJ Walters WA Widmann J Yatsunenko T Zaneveld J Knight R | 2010 | Nat Methods2010，7，5： | 1 |
| 18 | Genetic variation of brain-derived neurotrophic factor(BDNF)in bipolar disorder: case-control study of over 3?000 individuals from the UK显示文摘 | Green EK Raybould R Macgregor S | 2006 | Br J Psychiatry2006，188，： | 1 |
| 19 | Fruits and seeds of Craigia bronnii ( Malvaceae - Tili- oideae) and associated flower buds from the late Mio- cene Inden Formation, Lower Rhine Basin, Germany 显示文摘 | KVA~EK Z MANCHESTER S R ZETYER R | 2002 | Rev of Palaeobot and Palyn2002，119，： | 1 |
| 20 | Im- proved burn scar assessment with use of a new scar-rating scale 显示文摘 | Yeong EK Mann R Engrav LH | 1997 | Burn Care Reha- bil1997，18，4： | 1 |
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