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| 1 | Peripheral blood lymphocytes DNA in patients with chronic liver diseases显示文摘BACKGROUND Viral replication in blood cells with nucleuses may lead to the damage of lymphocytes genetic apparatus and the beginning of immunopathological reactions.AIM Of this investigation is to reveal the damage to peripheral blood lymphocytes (PBL)DNA in the patients with chronic liver diseases.MATERIALS AND METHODS Sixteen-ninepatients with chronic liver diseases (37 patients with chronic viral hepatitis, 2 patients with liver cirrhosis of mixed etiology (alcohol + virus G),30 women with primary biliary cirrhosis-PBC)were examined. The condition of DNA structure of PBL-was measured by the fluorescenceanalysis of DNA unwinding (FADU) technique with modification. Changes of fluorescence (in %) reflected the DNA distractions degree (thepresence of DNA single-stranded breaks and alkalinelabile sights).RESULTS AND CONCLUSION . The quantity of DNA single-stranded breaks and alkalinelabile sightsin DNA in all patients with chronic viral hepatitis .didnt differ from the control group,excluding the patients with chronic hepatitis (CH) C + G. Patients with HGV and TTV monoinfection had demonstrated the increase of the DNA single-stranded breaks PBL quantity.This fact may be connected with hypothesisabout the viruses replication in white blood cells discussed in the literature. Tendency to increase quantity of DNA PBL damages in the patients with primary biliary cirrhosis (PBC) accordingly to the alkaline phosphatase activity increase was revealed. Significant decrease of the DNA single-stranded breaks and alkalinelabile sights in the PBC patients that were treated with prednison was demonstrated. Probably, the tendency to increase the quantity of DNA singlestranded breaks and alkalinelabile sights in lymphocytes of the PBC patients was depended on the surplus of the blood bile acid content. | Vasiliy I Reshetnyak Tatyana I Sharafanova Ludmila U Ilchenko Elena V Golovanova Gennadiy G Poroshenko | 2001 | World Journal of Gastroenterology2001，7，2： | 6 |
| 2 | A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C显示文摘 | Bruno Sangro Carlos Gomez-Martin Manuel de la Mata Mercedes I?arrairaegui Elena Garralda Pilar Barrera Jose Ignacio Riezu-Boj Esther Larrea Carlos Alfaro Pablo Sarobe Juan José Lasarte Jose L. Pérez-Gracia Ignacio Melero Jesús Prieto | 2013 | Journal of Hepatology2013，，： | 6 |
| 3 | Computed tomography-based diagnostics might be insufficient in the determination of pancreatic cancer unresectability显示文摘AIM: To inquire into a question of an overestimation of arterial involvement in patients with pancreatic cancer (PC). METHODS: Radiology data were compared with the findings from 51 standard, 58 extended and 17 total pancreaticoduodenectomies; 9 distal resections with celiac artery (CA) excision; and 28 palliations for PC. The survival of 11 patients with controversial computed tomography (CT) and endoscopic ultrasound data with regard to arterial invasion, after R0/R1 procedures (false-positive CT results, Group A), was compared to survival after eight R2 resections (false-negative CT results, Group B) and after 12 bypass procedures for locally advanced cancer (true-positive CT results, Group C).RESULTS: In all of the cases in group A, operative exploration revealed no arterial invasion, which was predicted by CT. The one-year survival in Group A was 88.9%, and the two-year survival was 26.7%, with a median follow-up of 22 mo. One-year survival was not attained in groups B and C, with a significant difference in survival (P a-b = 0.0029, P b-c = 0.003).CONCLUSION: Arterial encasement on CT does not necessarily indicate arterial invasion. Whenever PC is considered unresectable, endoUS should be used. In patients with controversial CT an EUS data for peripan-creatic arteries involvement radical resection might be possible, providing survival benefits as compared to R2-resections or palliative surgery. | Vyacheslav I Egorov Roman V Petrov Elena N Solodinina Gregory G Karmazanovsky Natalia S Starostina Natalia A Kuruschkina | 2013 | World Journal of Gastrointestinal Surgery2013，5，4： | 4 |
| 4 | The AP-3 adaptor complex is required for vacuolar function in Arabidopsis显示文摘Subcellular trafficking 在真核细胞的房间为大量的功能被要求。它包含货物排序,在多重层次的泡形成, trafficking 和熔化过程的规定。适配器蛋白质(AP ) 建筑群是货物在酵母和哺乳动物排序进泡的关键管理者,但是他们在植物的存在和功能没被表明。这里,我们报导影响蛋白质的 trafficking 的鉴定 4 (pat4 ) 在通常认为的 δ 的变异的有缺陷者;AP-3 建筑群的子单元。pat4 和 pat2,从缺乏功能的通常认为的 AP-3 β 的一样的 GFP 基于成像的向前基因的屏幕孤立的异种;,以及主导的否定 AP-3 μ难辨别的显型由大部分正常的形态学和开发描绘了的转基因的线显示,而是在异常 vacuolar 结构的膜蛋白质的强壮的细胞内部的累积。所有异种在形态学和功能是有缺点的 lysin 并且蛋白质存储液泡(PSV ) 但是储备蛋白质排序到 PSV 的表演正常。Immunoprecipitation 实验和基因研究揭示了通常认为的 AP-3 β 的紧密的功能、物理的协会;并且 AP-3 δ子单元。而且,两蛋白质仔细与通常认为的 AP-3 μ 被连接;并且 σ子单元和 clathrin 和 dynamin 机械的几个部件。一起拿,这些结果表明那 AP 建筑群,类似于那些在另外的优核质,在植物,和那 AP-3 存在在植物房间在生物的续生说的规定和液泡的功能起一个特定的作用。 | Marta Zwiewka Elena Feraru Barbara Moller Inhwan Hwang Mugurel I Feraru Jargen Kleine-Vehn Dolf Weijers Jifi Friml | 2011 | Cell Research2011，21，12： | 3 |
| 5 | Synthesis of Gold Nanoparticles by Some Strains of Arthrobacter Genera显示文摘 | Tamaz Levan Kalabegishvi|i Elena Ivan Kirkesalt Alexander Nikoloz Rcheulishvili Etery Nikoloz Ginturi Ivane Giorgi Murusidze Dodo Trofim Pataraya Manana Amiran Gurielidze Giorgi Ilia Tsertsvadze Vakhtang Nikoloz Gabunia Levan Giorgi Lomidze David Nugzar Gvarialadze Marina VladimirovnaFrontasyeva Sergey Sergeevich Pavlov Inga Ivanovna Zinicovscaia Marianne Janette Raven Ntsoaki Maditselana Francinah Seaga Arnaud Faanhof | 2012 | 材料科学与工程(中英文A版)2012，2，2： | 2 |
| 6 | Genetic Structure of an Endangered Plant,Antirrhinum microphyllum (Scrophulariaceae):Allozyme and RAPD Analysis显示文摘 | Elena T Jose M I Cesar P | 2003 | American Journal of Botany2003，90，： | 1 |
| 7 | Determinants of Residential Land UseConversion and Sprawl At the Rural-urban Fringe显示文摘 | Camen C F G I Elena | 2004 | Ameri-can Agricultural Economics Association2004，86，4： | 1 |
| 8 | Design,synthesis and biological evaluation of novel potent MDM2/p53 small-molecule inhibitors显示文摘 | Yan A I Sergei V V Elena K B | 2015 | Bioorg Med Chem Lett2015，25，2： | 1 |
| 9 | Stability of Ag nanoparticles dispersed in amphiphilic organic matrix显示文摘 | Elena I S Vera V K Victor V K | 2004 | Journal of Crystal Growth2004，21，： | 1 |
| 10 | Zgurskaya AcrA,AcrB,and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex显示文摘 | Tikhonova Helen I | 2004 | Biol Chem2004，279，32： | 1 |
| 11 | Enalapril attenuates oxidative stress in diabetic rats显示文摘 | Elena MV de Cavanagh Felipe I | 2001 | Hypertension2001，38，6： | 1 |
| 12 | Enalapril attenuates oxidative stress in diabetic rats显示文摘 | Elena MV Felipe I Jorge T | 2001 | Hypertension2001，38，10： | 1 |
| 13 | Control of Colloidal Dissolved Materials in Papermaking Systems with High Content of Secondary Fiber显示文摘 | Bobu Elena Popa V I Moraru Tudorita | 1999 | Wochenblatt Fuer Papierfabrikation1999，127，1922： | 1 |
| 14 | Determinants of residential land use conversion and sprawl at the rural-urban fringe显示文摘 | Carmen C F Elena G I | 2004 | American Agricultural Economics Association2004，86，4： | 1 |
| 15 | Initial-boundary value problem for nonlinear pseudoparabolic equations in a critical case 显示文摘 | ELENA I K | 2007 | Electronic JDE2007，，109： | 1 |
| 16 | Ginkgolide B preferentially blocks chloride channels formed by heteromeric glycine receptors in hippocampal pyramidal neurons of rat显示文摘 | Elena L Kondratskaya Alexander I Fisyunov Shyam S Chattajee | 2004 | Brain Research Bulletin2004，63，： | 1 |
| 17 | Stable Functionalization of Small Semiconducting Polymer Dots via Covalent Cross‐Linking and Their Application for Specific Cellular Imaging显示文摘 | Jiangbo Yu Changfeng Wu Xuanjun Zhang Fangmao Ye Maria Elena Gallina Yu Rong I‐Che Wu Wei Sun Yang‐Hsiang Chan Daniel T. Chiu | 2012 | Adv. Mater2012，，26： | 1 |
| 18 | Interdependence between damage indices and ground motion parameters based on Hilbert-Huang transform 显示文摘 | P F Alvanitopoulos I Andreadis A Elenas | 2010 | Measurement Science and Technology2010，251，21： | 1 |
| 19 | Matrix meta Uopmteinases and tumor metastasis显示文摘 | Elena I Deryugina James P | 2006 | Cancer Metastasis Rev2006，25，： | 1 |
| 20 | Hyperhomocysteinemia in Liver Cir rhosis 显示文摘 | Carmen Berasain Jose An tonio Rodr i guez | 2001 | Hypertension2001，38，： | 1 |
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