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| 1 | Role of vitamin B_(12) on methylmalonyl-CoA mutase activity显示文摘Vitamin B 12 is an organometallic compound with important metabolic derivatives that act as cofactors of certain enzymes,which have been grouped into three subfamilies depending on their cofactors.Among them,methylmalonyl-CoA mutase (MCM) has been extensively studied.This enzyme catalyzes the reversible isomerization of L-methylmalonyl-CoA to succinyl-CoA using adenosylcobalamin (AdoCbl) as a cofactor participating in the generation of radicals that allow isomerization of the substrate.The crystal structure of MCM determined in Propionibacterium freudenreichii var.shermanii has helped to elucidate the role of this cofactor AdoCbl in the reaction to specify the mechanism by which radicals are generated from the coenzyme and to clarify the interactions between the enzyme,coenzyme,and substrate.The existence of human methylmalonic acidemia (MMA) due to the presence of mutations in MCM shows the importance of its role in metabolism.The recent crystallization of the human MCM has shown that despite being similar to the bacterial protein,there are significant differences in the structural organization of the two proteins.Recent studies have identified the involvement of an accessory protein called MMAA,which interacts with MCM to prevent MCM's inactivation or acts as a chaperone to promote regeneration of inactivated enzyme.The interdisciplinary studies using this protein as a model in different organisms have helped to elucidate the mechanism of action of this isomerase,the impact of mutations at a functional level and their repercussion in the development and progression of MMA in humans.It is still necessary to study the mechanisms involved in more detail using new methods. | Tóshiko TAKAHASHI-IIGUEZ Enrique GARCíA-HERNANDEZ Roberto ARREGUíN-ESPINOSA María Elena FLORES | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，6： | 3 |
| 2 | 上海市的老人照料者的负担:研究设计和初步结果显示文摘1986年,在计划进行上海阿尔采木病和痴呆流调时,William T,Liu领导的UIC研究小组决定加进照料者的描述性研究。本文描述研究设计并报告主要发现。在上海静安区,大约50%的老人照料者为子女和子女的配偶,独居老人极少;与认知障碍老人的照料者相比,躯体伤残老人的照料者体验到较多的应激,较重的负担,以及难以忍受照料者的行为问题。 | Elena Yu MPH William T 王征宇 M.S 张明园 | 1992 | 上海精神医学1992，4，A00： | 2 |
| 3 | Genetic Structure of an Endangered Plant,Antirrhinum microphyllum (Scrophulariaceae):Allozyme and RAPD Analysis显示文摘 | Elena T Jose M I Cesar P | 2003 | American Journal of Botany2003，90，： | 1 |
| 4 | Identification of the newly described Mycobacterium poriferae form tuberculous lesions of snakehead fish (Channa striatus) 显示文摘 | Enrico T Alessandro B Elena B | 1996 | Comp Immun Microbial Infect Dis1996，19，： | 1 |
| 5 | A wide role for Notch 1 signaling in acute leukemia显示文摘 | Raffaella C Andrea B Elena T | 2005 | Cancer Letters2005，219，1： | 1 |
| 6 | A plant caspase-like protease activated during the hypersensitive response显示文摘 | NINA V C SANG H K ELENA S T | 2004 | Plant Cell2004，16，： | 1 |
| 7 | Medicine:oral cyclic guanosine monophosphate (cGMP) desensitizes colonic afferents in an animal model of experimental colitis 显示文摘 | Elena Ustinova AB Reza T Currie M | 2008 | Am J Gastroenterol2008，103，1： | 1 |
| 8 | Preservation of porcine blood quality by means of lactic acid bacteria显示文摘 | Eduard D Elena S Monica T | 2006 | Meat Sci2006，，73： | 1 |
| 9 | Effect of comonomer composition on the controlled free radical copolymerization of styrene and maleic anhydride by reversible addition fragmentation chain transfer显示文摘 | Elena C Polina T Chuong B | 2003 | Polymer2003，，44： | 1 |
| 10 | Practitioner review: chronic fatigue syndrome in childhood显示文摘 | Elena Garralda M Chalder T | 2005 | J Child Psychol Psychiatry2005，46，11： | 1 |
| 11 | Surface functional properties of blood plasma protein fraction显示文摘 | EDUARD D ELENA S MONICA T | 2007 | European Food Research and Technology2007，226，： | 1 |
| 12 | Enalapril attenuates oxidative stress in diabetic rats显示文摘 | Elena MV Felipe I Jorge T | 2001 | Hypertension2001，38，10： | 1 |
| 13 | Inventory service-level agreements as coordination mechanisms: the effect of review periods 显示文摘 | Elena K Douglas T Andrew D | 2008 | Manufacturing and Service Operations Management2008，10，4： | 1 |
| 14 | Identification of the newly described Mycobacterium poriferae from tuberculous lesions of snakehead fish(Channa striatus)显示文摘 | Enrico T Alessandro B Elena B | 1996 | Comparative Immu- nology Microbiology and Infectious Diseases1996，19，1： | 1 |
| 15 | PIAS proteins as roprossors of Oct4 function显示文摘 | Elena T Anna M Vladimir N | 2007 | J Mol Biol2007，374，： | 1 |
| 16 | Effect of co monomer composition on the controlled free radical copolymerization of styrene and malefic anhydride by reversible addition-fragmentation chain transfer (RAFT) 显示文摘 | Elena C Polina T Chuong B | 2003 | Polymer2003，，44： | 1 |
| 17 | Rdationship between white matter hyperintensities, cortical thickness, and cognition显示文摘 | Anil M T Andrew T R Elena S | 2015 | Stroke2015，46，2： | 1 |
| 18 | 显示文摘 | Elena Bekyarova Erik T Thostenson Aiping Yu | 2007 | JPhys Chem C2007，111，17： | 1 |
| 19 | Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene☆显示文摘 | Victor R Gordeuk Angela Caleffi Elena Corradini Francesca Ferrara Russell A Jones Oswaldo Castro Onyinye Onyekwere Rick Kittles Elisa Pignatti Giuliana Montosi Cinzia Garuti Innocent T Gangaidzo Z.A.R Gomo Victor M Moyo Tracey A Rouault Patrick MacPhail A | 2003 | Blood Cells Molecules and Diseases2003，，3： | 1 |
| 20 | 显示文摘 | Elena Bekyarova Erik T Thostenson Aiping Yu | 2007 | JPhys Chem C2007，111，17： | 1 |
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