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| 1 | Efficacy and safety of botulinum toxin in treatment of anismus: A systematic review显示文摘AIM: To evaluate the efficacy and safety of botulinum toxin type A(BTX-A) in the management of patients with anismus. METHODS: An organized search of published literature was conducted using electronic databases including: Pub Med/MEDLINE, and Cochrane Central Register of Control ed Trials, also an internet-based search using 'Google Scholar' service was conducted. Both comparative and observational studies were included. We excluded irrelevant articles, editorials, case reports, reviews, and meta-analyses. The studies that followed the patients less than 6 mo were excluded. Variables collected were demographic data of the patients, technique of BTX-A injection and number of sessions, short-term and longterm clinical improvement, post-injection changes in electromyography(EMG), defecography, manometry, and balloon expulsion test, and complications recorded after BTX-A injection.RESULTS: Seven studies comprising 189 patients were included in the review. The median age of the patients was 41.2 years and female-to-male ratio was 1.3:1. The median dose of BTX-A injected per procedure was 100 IU(range, 20-100 IU). Lateral injection was done in five trails and combined lateral and posterior injections in two trials. Three studies used endorectal ultrasonographyguided technique, one study used EMG-guided technique,whereas the remaining three studies used manual palpation with the index finger. The median percentage of patients who reported initial improvement of symptoms was 77.4%(range 37.5%-86.7%), this percentage declined to a median of 46%(range 25%-100%) at 4 mo after injection of BTX-A. Rates of improvement evaluated by balloon expulsion test, EMG, and defecography ranged between(37.5%-80%),(54%-86.7%), and(25%-86.6%), respectively. Fourteen(7.4%) patients developed complications after injection of BTX-A. Complication rates across the studies ranged from 0% to 22.6%. CONCLUSION: Initial satisfactory improvement of symptoms after BTX-A injection remarkably deteriorated after 3 mo of the procedure. However, repeated injection may provide better sustained results with no additional morbidities. Further analysis of more patients is necessary to conclude the safety of BTX-A for the treatment of anismus. | Sameh Hany Emile Hossam Ayman Elfeki Hosam Ghazy Elbanna Mohamed Youssef Waleed Thabet Tito M Abd El-Hamed Basem Said Ahmed Lotfy | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016,7,3: | 3 |
| 2 | A Markov chain model for subsurface characterization: Theory and applications显示文摘 | Elfeki A Dekking M | 2001 | Mathematical Geology2001,33,5: | 1 |
| 3 | A Markov Chain Model for subsurface characterization theory and applications 显示文摘 | Elfeki A Dekking M | | Mathematical Geology0,33,5: | 1 |
| 4 | Incremental, online, and merge mining of partial periodic patterns in time-series databases 显示文摘 | AREF W G ELFEKY M G ELMAGARMID A K | 2004 | IEEE Trans on Knowledge and Data Engineering2004,16,3: | 1 |
| 5 | Periodicity Detection in Time Series Databases显示文摘 | Elfeky M Aref W Elmagarmid A K | 2005 | IEEE Transactions on Knowledge and Data Engineering2005,17,7: | 1 |
| 6 | Incremental, Online, and Merge Mining of Partial Periodic Patterns in Time-Series Databases 显示文摘 | Aref W G Elfeky M G Elmagamlid A K | 2004 | IEEE Transactions on Knowledge and Data Engineering2004,16,3: | 1 |
| 7 | A Markov chain model for subsurface characterization :Theory and applications 显示文摘 | Elfeki A Dekking M | 2001 | Mathematical Geology2001,33,5: | 1 |
| 8 | Geostatistical analysis using GIS for mapping groundwater quality:case study in the recharge area of Wadi Usfan,western Saudi Arabia显示文摘 | MARKO K AL-AMRI N S ELFEKI A M M | 2013 | Arabian Journal of Geosciences2013,13,: | 1 |
| 9 | A Markov chain model for subsurface characterization: theory and application显示文摘 | Elfeki A Dekking M | 2001 | Mathematical Geology2001,33,5: | 1 |
| 10 | A Markov Chain model for subsur- face characterization: Theory and applications显示文摘 | Elfeki A Dekking M | 2001 | Mathe- matical Geology2001,33,5: | 1 |
| 11 | A Markov chain model for subsurface characterization:Theory and applications显示文摘 | Elfeki A Dekking M | 2001 | Mathematical Geology2001,33,5: | 1 |
| 12 | A Markov chain model for subsurface char- acterization: theory and applications 显示文摘 | Elfeki A Dekking M | 2001 | Math Geol2001,33,5: | 1 |
| 13 | A Bayesian decision model for cost optimal record matching显示文摘 | Verykios V S Moustakides G V Elfeky M G | 2003 | The VLDB Joumal2003,12,1: | 1 |
| 14 | A Markov chain model for subsurface characterization:Theory and applications显示文摘 | Elfeki A Dekking M | 2001 | Mathematical Geology2001,33,5: | 1 |
| 15 | A Markov chain model for subsurface characterization:Theory and applications显示文摘 | ELFEKI A DEKKING M | 2001 | Math Geol2001,33,5: | 1 |
| 16 | Primary diffuse large B-cell lymphoma of the dura mater and cranial vault 显示文摘 | Galarza M Gazzeri R Elfeky HA | 2006 | Neurosurg Focus2006,21,11: | 1 |
| 17 | Incremental,Online,and Merge Mining of Partial Periodic Patterns in Time-series Databases显示文摘 | Aref W G Elfeky M G Elmagarmid A K | 2004 | IEEE Transactions on Knowledge and Data Engineering2004,16,3: | 1 |
| 18 | A elmagarmid, incremental, online and merge mining of partial periodic patterns in time-series databas- es显示文摘 | W Aref M Elfeky | 2004 | 1EEE Transactions Knowledge and Data Engineering2004,16,3: | 1 |
| 19 | ABayesian decision model for cost optimal record matc-hing显示文摘 | Verykios V S Moustakides G V Elfeky M G | 2003 | The VLDB Journal2003,12,1: | 1 |
| 20 | Incremental, Online, and Merge Mining of Partial Periodic Patterns in Time-series Databases显示文摘 | ArefW G Elfeky M G Elmagarmid A K | 2004 | IEEE Transactions on Knowledge and Data Engineering2004,16,3: | 1 |