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32篇 您的检索式：作者名="ELLINGTON L"

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	题名	作者	年代	出处	被引量
1	Protective effects of anti-ricin A-chain RNA aptamer against ricin toxicity显示文摘AIM: To investigate the therapeutic potential of an RNA ligand (aptamer) specific for the catalytic ricin A-chain (RTA), the protective effects of a 31-nucleo-tide RNA aptamer (31RA), which formed a high affi nity complex with RTA, against ricin-induced toxicity in cellbased luciferase translation and cell cytotoxicity assays were evaluated. METHODS: To test the therapeutic potential of anti-RTA aptamers in Chinese hamster ovary (CHO) AA8 cells stably transfected with a tetracycline regulat-able promoter, ricin ribotoxicity was measured using luciferase and ricin-induced cytotoxicity was ascertained by MTS cell proliferation assay with tetrazolium compound [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium]. RESULTS: Inhibition of protein synthesis by ricin in CHO AA8 cells resulted in diminished luciferase activity and treatment with polyclonal antibody against degly-cosylated RTA (dgA) neutralized the inhibitory effects of ricin on luciferase activity and protected against ricin-induced cytotoxicity as measured by MTS assay. The 31RA anti-RTA aptamer inhibited the translation of luciferase mRNA in cell-free reticulocyte translation as- say. 31RA aptamer also partially neutralized the inhibitory effects of ricin on luciferase activity and partially protected against ricin-induced cytotoxicity in CHO AA8 cells. CONCLUSION: We have shown that anti-RTA RNA aptamer can protect against ricin ribotoxicity in cellbased luciferase and cell cytotoxicity assays. Hence, RNA aptamer that inhibits RTA enzymatic activity represents a novel class of nucleic acid inhibitor that has the potential to be developed as a therapeutic agent for the treatment of ricin intoxication.	Shaoan Fan Feng Wu Frank Martiniuk Martha L Hale Andrew D Ellington Kam-Meng Tchou-Wong	2008	World Journal of Gastroenterology2008，14，41：	3
2	The effect of aging and cancer on the symptom experience and physical function of elderly breast cancer survivors显示文摘	Bellury L Pett MA Ellington L	2012	Cancer2012，118，24：	1
3	Safety of tenofovir during pregnancy for the mother and fetus: A systematic review显示文摘	Wang L Kourtis AP Ellington S	2013	Clin Infect Dis2013，57，12：	1
4	The effect of aging and cancer on the symptom experience and physical function of elderly breast cancer survivors显示文摘	Bellury L Pett MA Ellington L	2012	Cancer2012，118，24：	1
5	Intracellular Staph-ylococcus aureus:a mechanism for the indolence of osteomye-litis显示文摘	Ellington JK Harris M Webb L	2003	J Bone Joint Surg2003，85，6：	1
6	Leading-edge vortices in insect flight 显示文摘	Ellington C P Van den Berg C Willmott A P Thomas A L R		Nature 3840，1996，：	1
7	Multiplex PCR for rapid detection of genes encoding acquired metallo-beta-lac- tamases显示文摘	Ellington M J Kistler J Livermore D L	2007	] Antimicrob Chemother2007，59，2：	1
8	Leading-edge vortices in insect flight显示文摘	VAN DEN BERG C WILLMOTT A P THOMAS A L R	1996	Nature1996，384，：	1
9	Nurse responsiveness to cancer patient expressions of emotion显示文摘	Sheldon LK Ellington L Barrett R	2009	Patient Education and Counseling2009，76，1：	1
10	Leading-edge vortices in insect flight显示文摘	ELLINGTON C P BERG C Van Den WILLMOTT A P and THOMAS A L R	1996	Nature1996，384，：	1
11	Distribution of the ACME - arcA gene among methicillin - resistant Staphylococcus aureus from England and Wales显示文摘	Ellington MJ Yearwood L Ganner M	2008	J antimicrob chemother2008，61，1：	1
12	Difficult communication in nursing显示文摘	Sheldon LK Barrett R Ellington L	2006	Journal of Nursing Scholarship2006，38，2：	1
13	Involvement of mitogen-activated protein kinase pathways in staphylococcus aureus invasion of normal osteoblasts显示文摘	Ellington J K Elhofy A Bost K L	2001	Infect Immun2001，69，9：	1
14	Lung ul- trasound for the diagnosis of pneumonia in adults: a systematic review and meta-analysis显示文摘	Chavez M A Shams N Ellington L E	2014	Respir Res2014，，：	1
15	The mechanical power output of the flight muscles of blue breasted quail (Coturnix chinensis) during take off显示文摘	Askew G N Marsh R L Ellington C P	2001	Journal of Experimental Biology2001，204，21：	1
16	Determination of perchlorate in tobacco plants and tobacco products 显示文摘	Ellington J J Wolfe N L Garrison A W	2001	Environmental Science and Technology2001，35，15：	1
17	The effect of aging and cancer on the symptom experience and physical function of elderly breast cancer survivors显示文摘	Bellury L Pett M Ellington L	2012	Cancer2012，118，24：	1
18	Patterns of energy metabolism in the stone crab, Menippe mercenaria, during severe hypoxia and subsequent recovery 显示文摘	Albert J L Ellington W R	1985	Journal of Experimental Zoology1985，234，2：	1
19	Leading-edge vortices in insect flight显示文摘	BERG C V D WILLMOTT A P and THOMAS A L R	1996	Nature1996，384，：	1
20	Nurse re-sponsiveness to cancer patient expressions of emotion显示文摘	Sheldon L K Ellington L Barrett R	2009	Patient Educ Couns2009，76，1：	1

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