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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019,4,1: | 6 |
| 2 | Treatment of the postoperative ileus after bowel surgery with low-dose intravenoua erythromycin显示文摘 | Lightfoot AJ Eno M Kreder KJ | 2007 | Urology2007,69,4: | 1 |
| 3 | Who blogs? Personality predictors of bIogging 显示文摘 | Guadagno R E Okdie B M Eno C A | 2008 | Computers in Human Behavior2008,,24: | 1 |
| 4 | Evaluation of the effect of aging on retinal nerve fiber layer thickness measured by optical coherence tomography显示文摘 | Kanamori A Escano MF Eno A Nakamura M Maeda H Seya R | 2003 | Ophthalmologica2003,217,4: | 1 |
| 5 | Drug Identification through analysis of maggots 显示文摘 | Beyer J C Enos W F Stajie M | 1980 | Journal of Forensic Sciences1980,25,2: | 1 |
| 6 | Evaluation of ozone/biological treatment for disinfection by products control and biological stable water显示文摘 | Price M L Bailey R W Enos A K | 1993 | Ozone Science&Engineering1993,,15: | 1 |
| 7 | Short same-segmenti xation of tho-racolumbar burst fractures显示文摘 | Eno J J Chen J L Mitsunaga M M | 2012 | Hawaii J Med Public Health2012,71,1: | 1 |
| 8 | Short same-segment fixation of thoracolumbar burst fractures显示文摘 | Eno J J Chen J L Mitsunaga M M | 2012 | Hawaii J Med Public Health2012,71,1: | 1 |
| 9 | Short same-segment fixation of thoracolumbar burst fractures显示文摘 | Eno J J Chen J L Mitsunaga M M | 2012 | Hawaii J Med Public Health2012,71,1: | 1 |
| 10 | Estimating the sensitivity and specificity of diagnostic tests and disease prevalence when the true disease state is unknown 显示文摘 | Enoe C Georgiadis M P Johnson W O | 2000 | Prev Vet Med2000,,45: | 1 |
| 11 | Who blogs? Per- sonality predictors of blogging 显示文摘 | GUADAGNO R E OKDIE B M ENO C A | 2008 | Computers in Human Be- havior2008,24,5: | 1 |
| 12 | Chemotherapy time interval and development of platinum and taxane resistance in ovarian, fallopian, and peritoneal carcinomas 显示文摘 | Matsuo K Eno M L Im D | 2010 | Arch Gynecol Ob- stet2010,281,2: | 1 |
| 13 | Comparison of Certain Value-at-risk Estimation Methods for the Two-parameter Weibull Loss Distribution显示文摘 | GEBIZLIOGLU O L eno lu B KANTAR Y M | | 0,,11: | 1 |
| 14 | Who blogs? Personality predictors of blogging 显示文摘 | GUADAGNO R E OKDIE B M ENO C A | 2008 | Computers in Hu- man Behavior2008,24,: | 1 |
| 15 | A requirementfor cyclin-dependent kinase 6 in thymocyte develop-ment and tumorigenesis显示文摘 | Hu M G Deshpande A Enos M | 2009 | Cancer Research2009,69,3: | 1 |
| 16 | Who blogs? Person- ality predictors ofblogging显示文摘 | Guadagno Ik E Okdie B M Eno C A | 2008 | Computers in Human Behav- ior2008,24,5: | 1 |
| 17 | Permian and Triassic depositional history of the Yangtze Platform and Great Bank of Guizhou in the Nanpanjiang Basin of Guizbou and Guangxi, South China 显示文摘 | Lehrmmm D J Enos P Payne J L Montgomery P Wei Jiayong Yu Youyi Xiao Jiafei Orchard M J | 2005 | Albertiana2005,33,: | 1 |
| 18 | Timing of recovery from the end-Permian extinction: Geochronologic and biostratigraphic constraints from south China 显示文摘 | Lehrmann D J Rarnezani J Bowfing S A Martin M W Montgomery P Enos P Payne J L Orchard M J Wang Hongmei Wei Jiayong | 2006 | Geology2006,34,: | 1 |
| 19 | Preliminary re-search on plasma oxytocin in normal cycling women: investi -gating emotion and interpersonal distress显示文摘 | TURNER R A ALTEMUS M ENOS T | 1999 | Psychiatry1999,62,2: | 1 |
| 20 | Short same-segment fixation of thoracolumbar burst fractures显示文摘 | Eno J J Chen J L Mitsunaga M M | 2012 | Hawaii J Med Public Health2012,71,1: | 1 |