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| 1 | 黄芪总黄酮对扑热息痛所致肝损伤的防护机理探讨显示文摘目的 :研究黄芪总黄酮对扑热息痛所致肝损伤的防护机理。方法 :用高压液相测定扑热息痛及代谢产物和苯巴比妥诱导睡眠模型研究黄芪总黄酮 (TFA)对扑热息痛的代谢及TFA抗扑热息痛所致损伤的机理。结果 :TFA可明显降低尿中硫醚胺酸的浓度 ,其变化与TFA浓度成反比 ;但对其它代谢产物的影响无明显统计学差异。苯巴比妥诱导小鼠睡眠实验结果显示 ,TFA (10 0mg·kg-1)本身对苯巴比妥代谢无明显影响 (P >0 .0 5 ) ,扑热息痛 (40 0mg·kg-1)可显著延长小鼠的睡眠时间 (P <0 .0 0 1) ;但TFA (10 0mg·kg-1)明显缩短扑热息痛所延长的苯巴比妥诱导的睡眠时间 (P <0 .0 0 5 )。结论 | 汪德清 Critchley Julian AJH 丁保国 马艳青 赵海潞 Thomas G Neil 田亚平 Tomlinson B rian Critchley Lester AH James Anthony Edward | 2001 | 中国中药杂志2001，26，9： | 13 |
| 2 | Gastric intestinal metaplasia is associated with gastric dysplasia but is inversely correlated with esophageal dysplasia显示文摘AIM To determine which clinical factors might be associated with gastric intestinal metaplasia(IM) in a North American population.METHODS Pathology and endoscopy databases at an academicmedical center were reviewed to identify patients with and without gastric IM on biopsies for a retrospective cohort study. Patient demographics, insurance status, and other clinical factors were reviewed.RESULTS Four hundred and sixty-eight patients with gastric IM(mean age: 61.0 years ± 14.4 years, 55.5% female) and 171 without gastric IM(mean age: 48.8 years ± 20.8 years, 55.0% female) were compared. The endoscopic appearance of atrophic gastritis correlated with finding gastric IM on histopathology(OR = 2.05, P = 0.051). Gastric IM was associated with histologic findings of chronic gastritis(OR = 2.56, P < 0.001), gastric ulcer(OR = 6.97, P = 0.015), gastric dysplasia(OR = 6.11, P = 0.038), and gastric cancer(OR = 6.53, P = 0.027). Histologic findings of Barrett's esophagus(OR = 0.28, P = 0.003) and esophageal dysplasia(OR = 0.11, P = 0.014) were inversely associated with gastric IM. Tobacco use(OR = 1.73, P = 0.005) was associated with gastric IM.CONCLUSION Patients who smoke or have the endoscopic finding of atrophic gastritis are more likely to have gastric IM and should have screening gastric biopsies during esophagogastroduodenoscopy(EGD). Patients with gastric IM are at increased risk for having gastric dysplasia and cancer, and surveillance EGD with gastric biopsies in these patients might be reasonable. | Justin M Gomez James T Patrie Wissam Bleibel Jeanetta W Frye Bryan G Sauer Vanessa M Shami Edward B Stelow Christopher A Moskaluk Andrew Y Wang | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 3 |
| 3 | Determining the fluxes of Tl^+ and K^+ at the root surface of wheat and canola using Tl( I ) and K ion-selective microelectrodes显示文摘 | JAMES G H MICHAEL J O EDWARD B | 2010 | Plant Soil2010，335，1： | 1 |
| 4 | Development of a laser Raman spectrometer for deep-ocean science显示文摘 | Peter G Brewer George Malby Jill D Pasteris Sheri N White Edward T Peltzer B Wopenka J Freeman Mark O Brown | 2004 | Deep-Sea Research Part I2004，，5： | 1 |
| 5 | Manganese removal by break piont chlo- rination 显示文摘 | EDWARDS S E MCCAL L G B | 1947 | Water and Sweage Works1947，94，7： | 1 |
| 6 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 7 | The physiology of p16INK4A-mediated G1 proliferative arrest显示文摘 | Shapiro G I Edwards C D Rollins B J | | 0，，02： | 1 |
| 8 | A Note on the Effect of Farmer Mental Health on Adoption : The Case of Agri - environment Schemes 显示文摘 | Hounsome B Edwards R T Edwards - Jones G | 2006 | Agricultural Systems2006，91，3： | 1 |
| 9 | Experimental determination of the fate of rising co2 droplets in seawater显示文摘 | PETER G B EDWARD T P GERNOT F | 2002 | Environ Sci Technol2002，36，： | 1 |
| 10 | Two cytosolic glutamine synthetase isoforms of maize are specifically involved in the control of grain production 显示文摘 | Martin A Lee J Kichey T Gerentes D Zivy M Tatout C Dubois F Balliau T Valot B Davanture M Laforgue T T Quillere I Coque M Gallais A Moro M B G Bethencourt L Habash D Z Lea P J Charcosset A Perez P Murigneux A Sakakibara H Edwards K J Hirel B | 2006 | The Plant Cell2006，18，11： | 1 |
| 11 | Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA显示文摘 | Leslie A Kavanagh D Honeyborne I Pfafferott K Edwards C Pillay T Hilton L Thobakgale C Ramduth D Draenert R Le Gall S Luzzi G Edwards A Brander C Sewell A K Moore S Mullins J Moore C Mallal S Bhardwaj N Yusim K Phillips R Klenerman P Korber B Kiepiela P Walker B Goulder P | 2005 | J Exp Med2005，201，6： | 1 |
| 12 | Gene expression after freshwater transfer in gills and opercular epithelia of killifish: insight into divergent mechanisms of ion transport 显示文摘 | SCOTT G R CLAIBORNE J B EDWARDS S L | 2005 | Journal of Experimental Biology2005，208，14： | 1 |
| 13 | Quality retention in strawberry and carrot purees dried with Refractance Window^TM System显示文摘 | ABONYI B l FENG H TANG J EDWARDS C G CHEW B P MATTINSON D S FELLMAN J K | 2001 | Jour- nal of Food Science2001，67，： | 1 |
| 14 | 1990, Photosynthetic characteristics of cassava(Manihot esculenta), a C3 species with ehlorenchymatous bundle sheath cell 显示文摘 | Edwards G E Sheta E Moore B D Dai Z Franceschi V R Cheng S H Lin C H Ku M S B | 1990 | Plant and Cell Physiology1990，31，8： | 1 |
| 15 | Early stages of fertilization in vitro of human oocytes matured in vitro显示文摘 | Edwards R G Bavister B D Steptoe P C | 1969 | Nature1969，221，： | 1 |
| 16 | Effect of endosperm starch granule size distribution on milling yield in hard wheat 显示文摘 | Edwards M A Osborne B G Henry R J | 2008 | Journal of Cereal Science2008，48，： | 1 |
| 17 | Aaptation of the MIMICS Backscattering Model to the Agricultural Context - wheat and Canola at L and C Bands显示文摘 | Toure A Thom son K P B Edwards G | 1994 | IEEE Trans on G&RS1994，32，： | 1 |
| 18 | Pre-eclampsia(EPH-gestosis)-induced decrease of MMP-s content in the umbilical cord artery显示文摘 | ZOFIA G EDWARD B LECH R | 2003 | Clinica Chimica Acta2003，335，： | 1 |
| 19 | Protection of puru- vate,Pi dikinase from maize against cold lability by com- patible solutes 显示文摘 | Krall J B Edwards G E Audreo C S | 1989 | Plant Physiol1989，，89： | 1 |
| 20 | The effect of slime coatings of the serpentine minerals,chrysotile and lizardite on pentlandite flotation显示文摘 | Edwards C R Kipkie W B Agar G E | 1980 | International Journal of Mineral Processing1980，7，1： | 1 |
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