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| 1 | Current understandings of the pathogenesis of type 1 diabetes:Genetics to environment显示文摘Type 1 diabetes(T1D)is an autoimmune disease that usually strikes early in life,but can affect individuals at almost any age.It is caused by autoreactive T cells that destroy insulin-producing beta cells in the pancreas.Epidemiological studies estimate a prevalence of 1 in 300 children in the United States with an increasing incidence of 2%-5%annually worldwide.The daily responsibility,clinical management,and vigilance required to maintain blood sugar levels within normal range and avoid acute complications(hypoglycemic episodes and diabetic ketoacidosis)and long term micro-and macro-vascular complications significantly affects quality of life and public health care costs.Given the expansive impact of T1D,research work has accelerated and T1D has been intensively investigated with the focus to better understand,manage and cure this condition.Many advances have been made in the past decades in this regard,but key questions remain as to why certain people develop T1D,but not others,with the glaring example of discordant disease incidence among monozygotic twins.In this review,we discuss the field’s current understanding of its pathophysiology and the role of genetics and environment on the development of T1D.We examine the potential implications of these findings with an emphasis on T1D inheritance patterns,twin studies,and disease prevention.Through a better understanding of this process,interventions can be developed to prevent or halt it at early stages. | Adebola Matthew Giwa Rizwan Ahmed Zahra Omidian Neha Majety Kagan Ege Karakus Sarah M Omer Thomas Donner Abdel Rahim A Hamad | 2020 | World Journal of Diabetes2020，11，1： | 2 |
| 2 | Comparison of the effects of RNase-negative and wild-type classical swine fever virus on peripheral blood cells of infected pigs显示文摘 | Von Freyburg M Ege A Saalmuller A | 2004 | J Gen Virol2004，85，： | 1 |
| 3 | Exposure to environmental micro-organisms and childhood asthma显示文摘 | Ege MJ Mayer M Normand A | 2011 | N Engl J Med2011，364，8： | 1 |
| 4 | Transport of nanopartieles across an in vitro model of the human intestinal fol- licle associated epithelium 显示文摘 | Des Rieux A Ragnarsson EGE GullbergE | 2005 | Eur J Pharm Sci2005，25，45： | 1 |
| 5 | Determination of copper, cadmium and lead in seawater and mineral water by flame atomic absorp- tion spectrometry after coprecipitation with aluminum hy- droxide显示文摘 | Doner G Ege A | 2005 | Anal Chim Acta2005，547，1： | 1 |
| 6 | Central diastolic blood pres- sure is associated with the degree of coronary collateral develop- ment显示文摘 | Ege MR Zorlu A Yilmaz MB | 2013 | Angiology2013，64，7： | 1 |
| 7 | Diagnostic valule of unen- hanced helical CT in adult patient with suspected acute appendicitis显示文摘 | Ege G Akman H Sahin A | 2002 | British Journal of Radiology2002，，75： | 1 |
| 8 | Determination of copper,cadmium and lead in seawater and mineral water by flame atomic absorption spectrometry after coprecipitation with aluminum hydroxide 显示文摘 | Doner G Ege A | 2005 | Anal Chim Acta2005，547，： | 1 |
| 9 | The asthma epidemic 显示文摘 | Eder A Ege MJ | 2006 | N Engl J Med2006，355，21： | 1 |
| 10 | Diagnostic valule of unenhanced helical CT in adult patient with suspected acute appendicitis显示文摘 | Ege G Akman H Sahin A | 2002 | Br J Radiol2002，75，： | 1 |
| 11 | Playing the DISC:turning on TRAIL death receptor-mediated apoptosis in cancer显示文摘 | Pennarun B Meijer A de Vries EGE | 2010 | BBA-Rev Cancer2010，1805，2： | 1 |
| 12 | Mean platelet vol- ume: an important predictor of coronary collateral devel- opment 显示文摘 | Ege M R Aclkgoz S Zorlu A | 2013 | Platelets2013，24，3： | 1 |
| 13 | Mechanotransduc- tion and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibro- blasts显示文摘 | Calvo F Ege N Grande-Garcia A | 2013 | Nat Cell Biol2013，15，6： | 1 |
| 14 | Diagnostic value of unenhanced helical CT in adult patients with suspected acute appendicitis显示文摘 | G Ege H Akman A Sahin | 2002 | British Journal of Radiology2002，75，： | 1 |
| 15 | Diagnostic valule of unenhanced helical CT in adult patient with suspected acute appendicitis 显示文摘 | G Ege H Akman A Sahin | 2002 | British Journal of Radiology2002，75，： | 1 |
| 16 | Pre- diction of survival using absolute lymphocyte count for newly diagnosed patients with multiple myeloma:a retrospective study显示文摘 | EGE H GERTZ M A MARKOVIC S N | 2008 | Br J Haematol2008，141，： | 1 |
| 17 | Diagnostic value of unenhanced helical CT in adult patients with suspected acute appendicitis 显示文摘 | Ege G Akman H Sahin A | 2002 | Br J Radial2002，75，9： | 1 |
| 18 | Anaplastic thyroid carcinoma with long term survival after combined trealment: case report显示文摘 | Kumkahveciogtu O Ege B Poyraz A | 2007 | Endocr Regul2007，41，1： | 1 |
| 19 | Sagittal plane analysis of the open and closed methods in children with displaced supracondylar fractures of the humerus (a radiological study ) 显示文摘 | Turhan EC Aksoy C Ege A | 2008 | Arch Orthop Trauma Surg2008，7，： | 1 |
| 20 | Mean platelet volume:an important predictor of coronary collateral development显示文摘 | Ege MR Acikgoz S Zorlu A | 2013 | Platelets2013，24，3： | 1 |
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