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| 1 | Necrotizing enterocolitis: A multifactorial disease with no cure显示文摘Necrotizing enterocolitis is an inflammatory bowel disease of neonates with significant morbidity and mortality in preterm infants. Due to the multifactorial nature o the disease and limitations in disease models, early diagnosis remains challenging and the pathogenesis elusive. Although preterm birth, hypoxic-ischemic events formula feeding, and abnormal bacteria colonization are established risk factors, the role of genetics and vasoactive/inflammatory mediators is unclear Consequently, treatments do not target the specific underlying disease processes and are symptomatic and surgically invasive. Breast-feeding is the most effective preventative measure. Recent advances in the prevention of necrotizing enterocolitis have focused on bioactive nutrients and trophic factors in human milk. Developmen of new disease models including the aspect of prematurity that consistently predisposes neonates to the disease with multiple risk factors will improve our understanding of the pathogenesis and lead to discovery of innovative therapeutics. | Kareena L Schnabl John E Van Aerde Alan BR Thomson Michael T Clandinin | 2008 | World Journal of Gastroenterology2008，14，14： | 19 |
| 2 | Long-term survival following radiofrequency ablation of colorectal liver metastases: A retrospective study显示文摘AIM: To retrospectively evaluate the long-term survivalof patients that received radiofrequency ablation(RFA) therapies of colorectal liver metastases. METHODS: In 2005 to 2008, RFA of 105 colorectal liver metastases(CRLM) were performed on 49 patients in our institution. The liver metastases were evaluated, both before and after ablation therapies, with contrast enhanced computerised tomography and contrast enhanced ultrasonography. Histological evidence of malignant liver metastases was obtained in the few instances where contrast enhanced ultrasonography gave equivocal results. Accesses to the CRLM were guided ultrasonically in all patients. The data obtained from records of these ablations were retrospectively analysed and survival data were compared with existing studies in the literature.RESULTS: 1-, 2-, 3-, 4- and 5-year survival rates, when no stringent selection criteria were applied, were 92%, 65%, 51%, 41% and 29% respectively. To explore the impact of the number and size of CRLM on patients' survival, an exclusion of 13 patients(26.5%) with number of CRLM ≥ 5 and tumour size ≥ 40 mm resulted in 1-, 2-, 3-, 4- and 5-year survival rates improving to 94%, 69%, 53%, 42% and 31% respectively. It is of note that 9 of 49 patients developed extra-hepatic metastases, not visible or seen on pretreatment scans, just after RFA treatment. These patients had poorer survival. The development of extra-hepatic metastases in nearly 20% of the patients included in our study can partly account for modestly lower survival rates as compared with earlier studies in the literature.CONCLUSION: Our study underscores the fact that optimum patients' selection before embarking on RFA treatment is vitally important to achieving a superior outcome. | Simeon Niyi Babawale Thomas MandФe Jensen Jens BrФndum FrФkjr | 2015 | World Journal of Gastrointestinal Surgery2015，7，3： | 11 |
| 3 | Nutritional modulation of the inflammatory response in inflammatory bowel disease-From the molecular to the integrative to the clinical显示文摘Nutrient deficiencies are common in patients with inflammatory bowel disease (IBD). Both total parenteral and enteral nutrition provide important supportive therapy for IBD patients, but in adults these are not useful for primary therapy. Dietary intervention with omega-3 polyunsaturated fatty acids contained in fish oil may be useful for the care of IBD patients, and recent studies have stressed the role of PPAR on NFκB activity on the potential beneficial effect of dietary lipids on intestinal function. | Gary E Wild Laurie Drozdowski Carmela Tartaglia M Tom Clandinin Alan BR Thomson | 2007 | World Journal of Gastroenterology2007，13，1： | 6 |
| 4 | The future of underground spatial planning and the resulting potential risks from the point of view of mining subsidence engineering显示文摘The topic of ground movements in Germany has been studied extensively in the past,especially in the field of active mines.The active hard coal mines in Germany were finally shut down in 2018 and lignite mining is expected to take place only until 2038.The so-called long-term liabilities of the mine operators in Germany include,among other things,the long-term guarantee of stability and thus the monitoring of ground motion.So far,the economic use of underground mining in Germany was mainly the supply of raw materials.In the future,the underground storage of compressed air,methane or hydrogen will play an important role in renewable energy supply and climate change.Therefore,the underground storage space will become more important and the spatial planning is essential to ensure availability of safe underground openings for the various options of environmentally friendly energy storage.However,this renewed usage of underground openings may also bring new and sometimes unknown challenges of geomechanical influence.The aftermath of hard coal and lignite mining will be an increasing challenge in mining subsidence engineering.On the other hand,new possibilities due to underground spatial planning may lead to subsidence and/or heaving of the upper surface. | Carolina Brücker Axel Preuβe | 2020 | International Journal of Mining Science and Technology2020，30，1： | 4 |
| 5 | Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells 显示文摘 | Zeng Y Wagner E J Cullen BR | 2002 | Mol Cell2002，9，6： | 1 |
| 6 | Effect of dietary protein restriction of progression in patients with diabetic nephropathy显示文摘 | Hansen HP Tauber-Lassen E Jensen BR | 2002 | Kidney Int2002，62，： | 1 |
| 7 | Strategic alliances andsocial capital: A multi dimensional view 显示文摘 | Koka BR Prescott J E | 2002 | Strategic Management Journal2002，，23： | 1 |
| 8 | Impaired skin and hair follicle development in Runx2 deficient mice显示文摘 | Glotzer DJ Zelzer E Olsen BR | 2008 | Dev Biol2008，315，2： | 1 |
| 9 | Association between the A-2518G polymorphism in the monocyte chemoattractant protein-1 gene and insulin resistance and type 2 diabetes mellitus 显示文摘 | Simeoni E Hoffmann MM Winkelmann BR | 2004 | Diabetologia2004，47，9： | 1 |
| 10 | The role of twinning during dynamic recrystallization in alloy 800H显示文摘 | Wang X Br E Gottstein G | 2002 | Scripta Materialia2002，46，12： | 1 |
| 11 | Transition metal based magnetic refrigerants for room temperature applications 显示文摘 | Brück E Buschow K H J | 2002 | Nature2002，415，： | 1 |
| 12 | Detection of Increased Choline Compounds with Proton Nuclear Magnetic Resonance Spectroscopy Subsequent to Malignant Transformation of Humen Prostatic Epithelial Cells显示文摘 | Ackerstaff E Pflug BR Nelson SJ | 2001 | Cancer Res2001，61，9： | 1 |
| 13 | Detection of increased choline compounds with proton nuclear magnetic resonance spectrescopy subsequent transformation of prostatic epithelial cells显示文摘 | Ackerstaff E Pflug BR Nelson JB | 2001 | Cancer Res2001，61，9： | 1 |
| 14 | Transcatheter closure of very large atrial septal defects using the Amplatzer septal occluder显示文摘 | Kannan BR Francia E Sivakumar K | 2003 | Cathet Cardiavasc Intervent2003，59，4： | 1 |
| 15 | Association of RANTES G-403A gene polymorphism with increased risk of coronary arteriosclerosis显示文摘 | Simeoni E Winkelmann BR Hoffmann MM | | 0，，16： | 1 |
| 16 | The genetic sonogram : A method of risk assessment for Down syndrome in the second trimester显示文摘 | Bromley B Lieberman E Shipp TD Benacerraf BR | 2002 | J Ultrasound Med2002，21，： | 1 |
| 17 | A conserved a-helix es-sential for a type Ⅵ secretion-like system of Francisell tularensis显示文摘 | Jeanette E Br(o)ms Anders S | 2009 | Journal of Bacteriology2009，10，： | 1 |
| 18 | Etching heavy ion tracks in polycarbon-ate as template for copper nanowires显示文摘 | MOLARESM E T BRTZ J BUSCHMANNV | 2001 | NuclearInstruments and Methods in Physics Research B2001，185，14： | 1 |
| 19 | Ethnopharmacology of Mexican Asteraceae (Compositae)显示文摘 | Heinrich M Robles M West JE Ortiz de Montellano BR Rodriguez E | 1998 | Annu Rev Pharmacol Toxicol1998，38，6： | 1 |
| 20 | Clinical genetics of familial keloids 显示文摘 | Mameros AG Norris JE Olsen BR Reichenberger E | 2001 | Arch Dermatol2001，137，11： | 1 |
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