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42篇 您的检索式：作者名="Eisold"

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	题名	作者	年代	出处	被引量
1	The effect of adenovirus expressing wild-type p53 on 5-fluorouracil chemosensitivity is related to p53 status in pancreatic cancer cell lines显示文摘AIM: There are conflicting data about p53 function on cellular sensitivity to the cytotoxic action of 5-fluorouracil (5-FU).Therefore the objective of this study was to determine the combined effects of adenovirus-mediated wild-type (wt) p53 gene transfer and 5-FU chemotherapy on pancreatic cancer cells with different p53 gene status.METHODS: Human pancreatic cancer cell lines Capan-1^p53mut,Capan-2^p53wt, FAMPAC^p53mut, PANG1^p53mut, and rat pancreatic cancer cell lines AS^p53wt and DSL6A^p53null were used for in vitro studies. Following infection with different ratios of Adp53-particles (MOI) in combination with 5-FU, proliferation of tumor cells and apoptosis were quantified by cell proliferation assay (WST-1) and FACS (PI-staining). In addition, DSL6A syngeneic pancreatic tumor cells were inoculated subcutaneously in to Lewis rats for in vivostudies.Tumor size, apoptosis (TUNEL) and survival were determined.RESULTS: Ad-p53 gene transfer combined with 5-FU significantly inhibited tumor cell proliferation and substantially enhanced apoptosis in all four cell lines with an alteration in the p53 gene compared to those two cell lines containing wt-p53. In vivo experiments showed the most effective tumor regression in animals treated with Ad-p53 plus 5-FU. Both in vitroand in vivoanalyses revealed that a sublethal dose of Ad-p53 augmented the apoptotic response induced by 5-FU.CONCLUSION: Our results suggest that Ad-p53 may synergistically enhance 5-FU-chemosensitivity most strikingly in pancreatic cancer cells lacking p53 function. These findings illustrate that the anticancer efficacy of this combination treatment is dependent on the p53 gene status of the target tumor cells.	Sven Eisold Michael Linnebacher EduardRyschich DaliborAntolovic UlfHinz Ernst Klar Jan Schmidt	2004	World Journal of Gastroenterology2004，10，24：	14
2	Induction of an antitumoral immune response by wild type adenoassoeiated virus type 2 in an in vivo model of pancreatic carcinoma 显示文摘	Eisold S Schmidt J Rysehich E	2007	Pancreas2007，35，1：	1
3	Dendritic cells reduce number and function of CD4+CD25+ cells in cytokine-induced killer cells derived from patients with pancreatic carcinoma显示文摘	SCHMIDT J EISOLD S BUCHLER M W	2004	Cancer Immunol Immunother2004，53，11：	1
4	Multidrug - resistance proteins are weak tumor associated antigens for colorectal carcinoma 显示文摘	Mullins CS Eisold S Klar E	2011	BMC Immunol2011，12，：	1
5	Experimental study of cardiorespiratory and stress factors in esophageal surgery using robot-assisted thoracoscopic or open thoracic approach显示文摘	Eisold S Mehrabi A Konstantinidis L	2008	Arch Surg2008，143，2：	1
6	Dendritic cells reduce number and function of CD4^+ CD25^+ ceils in cytokine-induced killer cells derived from patients with pancreatic carcinoma 显示文摘	Schmidt J Eisold S Buchler MW	2004	Cancer Immunol Immunother2004，53，11：	1
7	Induction of protective immunity against syngeneic rat cancer cells by expression of the cytosine deaminase suicide gene 显示文摘	Hsack K Linnebacher M Eisold S	2000	Cancer Gene Ther2000，7，10：	1
8	Induction of an antitumoral immune response by wild-type adeno-associated virus type 2 in an in vivo model of pancreatic carcinoma显示文摘	Eisold S Schmidt J Ryschich E	2007	Pancreas2007，35，1：	1
9	Notes on lifelong resilience : Perceptual and personalityfactors implicit in the creation of a particular adaptive style 显示文摘	Eisold BK	2005	Psychoanal Psychol2005，22，3：	1
10	Dendritic cells reduce number and function of CD4+CD25+ cells in cytokine-induced killer cells derived from patients with pancreatic carcinoma显示文摘	Schmidt J Eisold S Buchler MW	2004	Cancer Immunol Immunother2004，53，11：	1
11	Induction of Protective Immunity Against Syngeneic Rat Cancer Cells by Expression of the Cytosine Deaminase Suicide Gene显示文摘	Haack K Linnebacher M Eisold S	2000	Cancer Gene Ther2000，7，10：	1
12	Induction of an antitumoral immune response by wild-type adeno-associated virus type 2 in an in vivo model of pancreatic carcinoma显示文摘	Eisold S Schmidt J Ryschich E		0，，：	1
13	Dendritic cells reduce number and function of CD4+CD25+ cells in cytokine-induced killer cells derived from patients with pancreatic carcinoma 显示文摘	Schmidt J Eisold S Btichler MW	2004	Cancer Immunol Immunother2004，53，11：	1
14	Dendritic cellsreduce number and function of CD4^+ CD25^+ ceils in cytokine - induced killer cells derived from patients with pancreaticcarcinoma 显示文摘	Schmidt J Eisold S Buchler MW	2004	Cancer Immunol Immunother2004，53，11：	1
15	Dendritic cells reduce number and function of CD4+CD25+ cells in cy- tokine-induced killer cells derived from patients with pan- creatic carcinoma显示文摘	Schmidt J Eisold S Btichler MW	2004	Cancer Immunol Immunother2004，53，11：	1
16	Dendritic cells reduce number and function of CD4^+ CD25^+ cells in cytokine-induced killer cells deri ed from patients with pancreatic carcinoma显示文摘	Schmidt J Eisold S Buchler MW	2004	Cancer Immunol Immunother2004，53，11：	1
17	Dendritic cells reduce number and function of CD4^+ CD25^+ cells in cytokine-induced killer cells derived from patients with pancreatic carcinoma显示文摘	Schmidt J Eisold S Buchler MW	2004	Cancer Immunol Immunother2004，53，：	1
18	Dendritic cells reduce number and function of CD4+ CD25+ cells in cytokine-induced killer cells derived from patients with pancreatic carcinoma 显示文摘	SCHMIDT J EISOLD S BUCHLER MW	2004	Cancer Immunol Immunother2004，53，11：	1
19	Dendritic cells reduce number and function of CD4+CD25+ cells in cytokineinduced killer cells derived from patients with pancreatic carcinoma显示文摘	Schmidt J Eisold S Buchler M W	2004	Cancer Immunol Immunother2004，53，11：	1
20	Dendritic cells reduce number and function of CD^+ CD25 ^+ cells in cytokine-induced killer cells derived from patients with pancreatic carcinoma显示文摘	Schmidt J Eisold S Buchler MW	2004	Cancer Immunol Immunother2004，53，11：	1

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