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| 1 | Role of endoscopic ultrasonography in the loco-regional staging of patients with rectal cancer显示文摘The prognosis of rectal cancer(RC) is strictly related to both T and N stage of the disease at the time of diagnosis. RC staging is crucial for choosing the best multimodal therapy: patients with high risk locally advanced RC(LARC) undergo surgery after neoadjuvant chemotherapy and radiotherapy(NAT); those with low risk LARC are operated on after a preoperative short-course radiation therapy; finally, surgery alone is recommended only for early RC. Several imaging methods are used for staging patients with RC: computerized tomography, magnetic resonance imaging, positron emission tomography, and endoscopic ultrasound(EUS). EUS is highly accurate for the loco-regional staging of RC, since it is capable to evaluate precisely the mural infiltration of the tumor(T), especially in early RC. On the other hand, EUS is less accurate in restaging RC after NAT and before surgery. Finally, EUS is indicated for follow-up of patients operated on for RC, where there is a need for the surveillance of the anastomosis. The aim of this review is to highlight the impact of EUS on the management of patients with RC, evaluating its role in both preoperative staging and follow-up of patients after surgery. | Pietro Marone Mario de Bellis Valentina D'Angelo Paolo Delrio Valentina Passananti Elena Di Girolamo Giovanni Battista Rossi Daniela Rega Maura Claire Tracey Alfonso Mario Tempesta | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，7： | 11 |
| 2 | Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy显示文摘Background:Parkinson’s disease(PD)is a neurodegenerative disorder whose diagnosis is often challenging because symptoms may overlap with neurodegenerative parkinsonisms.PD is characterized by intraneuronal accumulation of abnormalα-synuclein in brainstem while neurodegenerative parkinsonisms might be associated with accumulation of eitherα-synuclein,as in the case of Multiple System Atrophy(MSA)or tau,as in the case of Corticobasal Degeneration(CBD)and Progressive Supranuclear Palsy(PSP),in other disease-specific brain regions.Definite diagnosis of all these diseases can be formulated only neuropathologically by detection and localization ofα-synuclein or tau aggregates in the brain.Compelling evidence suggests that trace-amount of these proteins can appear in peripheral tissues,including receptor neurons of the olfactory mucosa(OM).Methods:We have set and standardized the experimental conditions to extend the ultrasensitive Real Time Quaking Induced Conversion(RT-QuIC)assay for OM analysis.In particular,by using human recombinantα-synuclein as substrate of reaction,we have assessed the ability of OM collected from patients with clinical diagnoses of PD and MSA to induceα-synuclein aggregation,and compared their seeding ability to that of OM samples collected from patients with clinical diagnoses of CBD and PSP.Results:Our results showed that a significant percentage of MSA and PD samples inducedα-synuclein aggregation with high efficiency,but also few samples of patients with the clinical diagnosis of CBD and PSP caused the same effect.Notably,the final RT-QuIC aggregates obtained from MSA and PD samples owned peculiar biochemical and morphological features potentially enabling their discrimination.Conclusions:Our study provide the proof-of-concept that olfactory mucosa samples collected from patients with PD and MSA possess important seeding activities forα-synuclein.Additional studies are required for(i)estimating sensitivity and specificity of the technique and for(ii)evaluating its application for the diagnosis of PD and neurodegenerative parkinsonisms.RT-QuIC analyses of OM and cerebrospinal fluid(CSF)can be combined with the aim of increasing the overall diagnostic accuracy of these diseases,especially in the early stages. | Chiara Maria Giulia De Luca Antonio Emanuele Elia Sara Maria Portaleone Federico Angelo Cazzaniga Martina Rossi Edoardo Bistaffa Elena De Cecco Joanna Narkiewicz Giulia Salzano Olga Carletta Luigi Romito Grazia Devigili Paola Soliveri Pietro Tiraboschi Giuseppe Legname Fabrizio Tagliavini Roberto Eleopra Giorgio Giaccone Fabio Moda | 2019 | Translational Neurodegeneration2019，8，1： | 5 |
| 3 | Aeromonas veronii biovar veronii and sepsis-infrequent complication of biliary drainage placement: A case report显示文摘BACKGROUND Aeromonas species are uncommon pathogens in biliary sepsis and cause substantial mortality in patients with impaired hepatobiliary function. Asia has the highest incidence of infection from Aeromonas,whereas cases in the west are rare.CASE SUMMARY We report the case of a 64-year-old woman with advanced pancreatic cancer and jaundice who manifested fever,abdominal pain,severe thrombocytopenia,anemia and kidney failure following the insertion of a percutaneous transhepatic biliary drainage. Blood culture results revealed the presence of Aeromonas veronii biovar veronii(A. veronii biovar veronii). After antibiotic therapy and transfusions,the life-threatening clinical conditions of the patient improved and she was discharged.CONCLUSION This was a rare case of infection,probably the first to be reported in West countries,caused by A. veronii biovar veronii following biliary drainage. A finding of Aeromonas must alert clinician to the possibility of severe sepsis. | Manlio Monti Arianna Torri Elena Amadori Alice Rossi Giulia Bartolini Chiara Casadei Giovanni Luca Frassineti | 2019 | World Journal of Clinical Cases2019，7，6： | 4 |
| 4 | Primary Lung Cancer Presenting with Gastrointestinal Tract Involvement: Clinicopathologic and Immunohistochemical Features in a Series of 18 Consecutive Cases显示文摘 | Giulio Rossi Alessandro Marchioni Elena Romagnani Federica Bertolini Lucia Longo Alberto Cavazza Fausto Barbieri | 2007 | Journal of Thoracic Oncology2007，，2： | 2 |
| 5 | Risk factor and etiology analysis of ischemic stroke in young adult patients显示文摘 | Rosaria Renna Fabio Pilato Paolo Profice Giacomo Della Marca Aldobrando Broccolini Roberta Morosetti Giovanni Frisullo Elena Rossi Valerio De Stefano Vincenzo Di Lazzaro | 2013 | Journal of Stroke and Cerebrovascular Diseases2013，，： | 2 |
| 6 | Cerebral sinus-venous thrombosis显示文摘 | Ida Martinelli Serena Maria Passamonti Elena Rossi Valerio De Stefano | 2012 | Internal and Emergency Medicine2012，，3： | 2 |
| 7 | Role of the advanced glycation end products receptor in Crohn's disease inflammation显示文摘AIM:To investigate the level of mucosal expression and the involvement of the receptor for the advanced glycation end products(RAGE)in delayed apoptosis and tumor necrosis factor(TNF)-αproduction in Crohn’s disease(CD).METHODS:Surgical and endoscopic specimens from both inflamed and non-inflamed areas of the ileum and/or colon were collected from 20 and 14 adult CD patients,respectively,and used for the assessment of RAGE expression by means of immunohistochemistry and western blotting analysis.Normal tissues from 21 control subjects were used for comparison.The same polyclonal anti-human RAGE antibody(R and D System)was used in all experimental conditions.RAGE staining was quantized by a score including both the amount of positive cells and intensity of immunoreactivity;cellular pattern was also described.The effects of RAGE blocking on apoptotic rate and TNF-αproduction were investigated on immune cells freshly isolated from CD mucosa and incubated both with and without the muramyl dipeptide used as antigenic stimulus.Statistical analysis was performed via the test for trend,with regression models to account for intra-patient correlations.A 2-sided P<0.05 was considered significant.RESULTS:In inflamed areas,RAGE expression in both the epithelial and lamina propria compartments was higher than control tissues(P=0.001 and 0.021,respectively),and a cluster of positive cells were usually found in proximity of ulcerative lesions.Similar results were obtained in the lamina propria compartment of non-inflamed areas(P=0.025).The pattern of staining was membranous and granular cytosolic at the epithelial level,while in the lamina propria it was diffuse cytosolic.When evaluating the amount of protein expression by immunoblotting,a significant increase of both surface area and band intensity(P<0.0001 for both)was observed in CD inflamed areas compared to control tissue,while in non-inflamed areas a significant increase was found only for band intensity(P<0.005).Moreover,a significantly lower expression in noninflamed areas in comparison with inflamed areas was found for both surface area and band intensity(P<0.0006 for both).Finally,RAGE blocking largely affects both the apoptotic rate of mucosal cells(towards an increase in both non-inflamed and inflamed areas of P<0.001 and<0.0001,respectively)and TNF-αsecretion(towards a decrease in both non-inflamed and inflamed areas of P<0.05 and<0.01,respectively),mainly in the presence of antigenic stimulation.CONCLUSION:RAGE is up-regulated in CD,especially in inflamed areas,and it appears to play a role in the mechanisms involved in chronic inflammation. | Rachele Ciccocioppo Alessandro Vanoli Catherine Klersy Venerina Imbesi Vincenzo Boccaccio Rachele Manca Elena Betti Giuseppina Cristina Cangemi Elena Strada Roberta Besio Antonio Rossi Colomba Falcone Sandro Ardizzone Paolo Fociani Piergiorgio Danelli Gino Roberto Corazza | 2013 | World Journal of Gastroenterology2013，19，45： | 2 |
| 8 | Effect of fruit blanching on phenolic and radical scavenging activity of highbush blueberry juice显示文摘 | Margherita Rossi Elena Giussani Roberto Moreu | 2003 | Food Research International2003，36，： | 1 |
| 9 | Effect of fruit blanching on phenolics and radical scavenging activity of highbush blueberry juice显示文摘 | Margherita Rossi Elena Giussani | 2003 | Food Research International2003，36，： | 1 |
| 10 | Effect of fruit blanching on phenolics and radical scavenging activity of highbush blueberry juice显示文摘 | Margherita Rossi Elena Giussani Roberto Morelli Roberto Lo Scalzo Renato C. Nani Danila Torreggiani | 2003 | Food Research International2003，，9： | 1 |
| 11 | Influence of proband’s characteristics on the risk for venous thromboembolism in relatives with factor V Leiden or prothrombin G20210A polymorphisms显示文摘 | Paolo Bucciarelli Valerio De Stefano Serena M. Passamonti Daniela Tormene Cristina Legnani Elena Rossi Giancarlo Castaman Paolo Simioni Michela Cini Ida Martinelli | 2013 | Blood2013，，15： | 1 |
| 12 | Influence of the JAK2 V617F mutation and inherited thrombophilia' on the thrombotic risk among patients with essential thrombocythemia显示文摘 | Valerio De Stefano Tommaso Za Elena Rossi | 2009 | Haematologica2009，94，5： | 1 |
| 13 | Influence of proband’s characteristics on the risk for venous thromboembolism in relatives with factor V Leiden or prothrombin G20210A polymorphisms显示文摘 | Paolo Bucciarelli Valerio De Stefano Serena M. Passamonti Daniela Tormene Cristina Legnani Elena Rossi Giancarlo Castaman Paolo Simioni Michela Cini Ida Martinelli | 2013 | Blood2013，，15： | 1 |
| 14 | Peripheral microvascular dysfunction as an independent predictor of atherosclerotic damage in type 1 diabetes patients: A preliminary study显示文摘 | Marco Rossi Elena Matteucci Margherita Pesce Cristina Consani Ferdinando Franzoni Gino Santoro Ottavio Giampietro | 2013 | Clinical Hemorheology and Microcirculation2013，，4： | 1 |
| 15 | Climate change impacts on groundwater and dependent ecosystems显示文摘 | Bj?rn Kl?ve Pertti Ala-Aho Guillaume Bertrand Jason J. Gurdak Hans Kupfersberger Jens Kv?rner Timo Muotka Heikki Mykr? Elena Preda Pekka Rossi Cintia Bertacchi Uvo Elzie Velasco Manuel Pulido-Velázquez | 2013 | Journal of Hydrology2013，，： | 1 |
| 16 | Hypoxia Inducible Factor-1α Inactivation Unveils a Link between Tumor Cell Metabolism and Hypoxia-Induced Cell Death显示文摘 | Elena Favaro Giorgia Nardo Luca Persano Massimo Masiero Lidia Moserle Rita Zamarchi Elisabetta Rossi Giovanni Esposito Mario Plebani Ulrike Sattler Thomas Mann Wolfgang Mueller-Klieser Vincenzo Ciminale Alberto Amadori Stefano Indraccolo | 2008 | The American Journal of Pathology2008，，4： | 1 |
| 17 | Alternative splicing and nonsense-mediated mRNA decay in the regulation of a new adenomatous polyposis coli transcript显示文摘 | Marina De Rosa Gemma Morelli Elena Cesaro Francesca Duraturo Mimmo Turano Giovanni B. Rossi Paolo Delrio Paola Izzo | 2007 | Gene2007，，1： | 1 |
| 18 | Inflammatory profile in subcutaneous and epicardial adipose tissue in men with and without diabetes显示文摘 | Clara Bambace Anna Sepe Elena Zoico Mariassunta Telesca Debora Olioso Sara Venturi Andrea Rossi Francesca Corzato Silvia Faccioli Luciano Cominacini Francesco Santini Mauro Zamboni | 2014 | Heart and Vessels2014，，1： | 1 |
| 19 | Summer distribution, abundance and population structure oflllex argentinus on the Argentine shelf in relation to environmental features显示文摘 | Brunetti N E Elena B Rossi G R | 1998 | South African Journal of Marine Science1998，20，1： | 1 |
| 20 | Effect of fruit blanching on phenolics and radical scavenging activity of highbush blueberry juice显示文摘 | Margherita Rossi Elena Giussani | 2003 | Food Research International2003，36，： | 1 |
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