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| 1 | Histone Acetylation, VERNALIZATION INSENSITIVE 3, FLOWERING LOCUS C, and the Vernalization Response显示文摘由低温度的 VIN3 的量的正式就职在 Arabidopsis 为 FLC 的 PRC2 压抑和 flowering (开花结实促进法) 的提升被要求。Histone acetylation,通常与基因抄写联系的染色质修正,响应低温度在二个空间地并且时间地不同的阶段在 VIN3 染色质上增加了。在短期的冷暴露期间,在抄写开始地点的 histone H3 acetylation 很快增加了,暗示它为 VIN3 正式就职被要求。在 histone H3 和 H4 acetylation 的随后的变化发生了在延长冷暴露期间跟随继续的 VIN3 抄写。包括 histone acetyltransferase GCN5,它导致冷环境适应小径基因的表示,像英雄传奇的 transcriptional 适配器建筑群的成员不调整在冷暴露期间感应的 VIN3,显示冷环境适应小径并且 VIN3 冷正式就职被不同 transcriptional 机制调整。在另外的 11 histone acetyltransferase 基因的变化没影响 VIN3 正式就职。然而,在 VIN3 地点的菸碱,一个 histone deacetylase 禁止者,导致的 VIN3 和改变的 histone acetylation。VIN3 正式就职与菸碱处理的长度成正比,它与 FLC 的早花的显型和压抑被联系。然而, FLC 的压抑不同于开花结实促进法,独立于 VIN3 活动。菸碱处理没在 PRC2 建筑群的自治小径或成员在任何基因的表示引起一个变化, FLC 的很好描绘的抑压者。我们的数据建议 FLC 经由包含 histone deacetylases 的 SIR2 类的一条新奇小径被镇压。 | Donna M. Bond Elizabeth S. Dennis Barry J. Pogson E. Jean Finnegan | 2009 | Molecular Plant2009，2，4： | 8 |
| 2 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 3 | Cell:癌基因“遗传平衡”或会影响患者对癌症疗法的反应显示文摘进行癌症疗法的选择越来越需要确定肿瘤细胞中是否含有一些特殊突变的癌基因会驱动癌细胞异常生长。并且确定是否癌细胞会对特殊药物耐受或敏感.近日来自加州大学旧金山分校的研究人员就通过研究发现。以常见的癌基因KRAs突变为例。患者对疗法的反应往往会随着肿瘤的不断进化而发生改变。相关研究刊登于国际杂志Cell上。 | Michael R. Burgess Eugene Hwang Rana Mroue Craig M. Bielski Anica M. Wandler Benjamin J. Huang Ari J. Firestone Amy Young Jennifer A. Lacap Lisa Crocker Saurabh Asthana Elizabeth M. Davis Jin Xu Keiko Akagi Michelle M. Le Beau Qing Li Benjamin Haley David Stokoe Deepak Sampath Barry S. Taylor Marie Evangelista Kevin Shannon | 2017 | 现代生物医学进展2017，17，18： | 2 |
| 4 | A Lethally Irradiated Allogeneic Granulocyte-Macrophage Colony Stimulating Factor-Secreting Tumor Vaccine for Pancreatic Adenocarcinoma: A Phase II Trial of Safety, Efficacy, and Immune Activation显示文摘 | Lutz Eric Charles J. Yeo Keith D. Lillemoe Barbara Biedrzycki Barry Kobrin Joseph Herman Elizabeth Sugar Steven Piantadosi John L. Cameron Sara Solt Beth Onners Irena Tartakovsky Miri Choi Rajni Sharma Peter B. Illei Hruban Ralph H. Ross A. Abrams Dung Le | 2011 | Annals of Surgery2011，，2： | 2 |
| 5 | Preservation of immune function in cervical cancer patients during chemoradiation using a novel integrative approach显示文摘 | Susan K. Lutgendorf Elizabeth Mullen-Houser Daniel Russell Koen DeGeest Geraldine Jacobson Laura Hart David Bender Barrie Anderson Thomas E. Buekers Michael J. Goodheart Michael H. Antoni Anil K. Sood David M. Lubaroff | 2010 | Brain Behavior and Immunity2010，，8： | 2 |
| 6 | Ecology versus issue interpretation : the analysis of two different messages显示文摘 | KNAPP Doug BARRIE Elizabeth | 1998 | Journal of Interpretation Research1998，3，1： | 1 |
| 7 | Disclosing Medical Errors to Patients: Attitudes and Practices of Physicians and Trainees显示文摘 | Lauris C. Kaldjian Elizabeth W. Jones Barry J. Wu Valerie L. Forman-Hoffman Benjamin H. Levi Gary E. Rosenthal | 2007 | Journal of General Internal Medicine2007，，7： | 1 |
| 8 | Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: potential clinical relevance显示文摘 | Elizabeth R. Glaze Amy L. Lambert Adaline C. Smith John G. Page William D. Johnson David L. McCormick Alan P. Brown Barry S. Levine Joseph M. Covey Merrill J. Egorin Julie L. Eiseman Julianne L. Holleran Edward A. Sausville Joseph E. Tomaszewski | 2005 | Cancer Chemotherapy and Pharmacology2005，，6： | 1 |
| 9 | Reference genome sequence of the model plant Setaria显示文摘 | Jeffrey L Bennetzen Jeremy Schmutz Hao Wang RyanPercifield Jennifer Hawkins Ana C Pontaroli Matt Estep Liang Feng Justin N Vaughn Jane Grimwood JerryJenkins Kerrie Barry Erika Lindquist Uffe Hellsten Shweta Deshpande Xuewen Wang Xiaomei Wu ThereseMitros Jimmy Triplett Xiaohan Yang Chu-Yu Ye Margarita Mauro-Her-rera Lin Wang Pinghua Li ManojSharma Rita Sharma Pamela C Ronald Olivier Panaud Elizabeth A Kellogg Thomas P Brutnell Andrew NDoust Gerald A Tuskan Daniel Rokhsar Katrien MDevos | 2012 | Nature Biotechnology2012，，30： | 1 |
| 10 | Identification of a nuclear receptor that is activated by farnesol metabolites显示文摘 | Barry M Forman Elizabeth Goode Jasmine Chen Anthony E Oro David J Bradley Thomas Perlmann Daniel J Noonan Leo T Burka Trevor McMorris William W Lamph Ronald M Evans Cary Weinberger | 1995 | Cell1995，，5： | 1 |
| 11 | Malnutrition and Energy Re- striction Differentially Affect Viral Immunity显示文摘 | Ritz Barry W Elizabeth M Gardner | 2006 | Journal of Nutri- tion2006，136，： | 1 |
| 12 | CPR quality improvement during in-hospital cardiac arrest using a real-time audiovisual feedback system显示文摘 | Benjamin S. Abella Dana P. Edelson Salem Kim Elizabeth Retzer Helge Myklebust Anne M. Barry Nicholas O’Hearn Terry L. Vanden Hoek Lance B. Becker | 2006 | Resuscitation2006，，1： | 1 |
| 13 | Investigation of the role of SREBP-1c in the pathogenesis of HCV-related steatosis显示文摘 | Stuart McPherson Julie R. Jonsson Helen D. Barrie Peter O’Rourke Andrew D. Clouston Elizabeth E. Powell | 2008 | Journal of Hepatology2008，，6： | 1 |
| 14 | Intakes of plain water, moisture in foods and bevera- ges, and total water in the adult US population-nutritional, meal pattern, and body weight correlates: National Health and Nutrition Examination Surveys 1999--2006 显示文摘 | Ashima K Kan t Barry I Graubard Elizabeth A Atch ison | 2009 | Am J Clin Nutr2009，90，： | 1 |
| 15 | Serotonin:a regulator of neuronal morphology and circuitry显示文摘 | Elizabeth A D Barry G C | 2010 | Trends in Neurosciences2010，33，： | 1 |
| 16 | Intakes of plain water, moisture in foods and bevera- ges, and total water in the adult US population -nutritional, meal pattern, and body weight correlates: National Health and Nutrition Examination Surveys 1999-2006l-3 显示文摘 | Ashima K Kan t Barry I Graubard Elizabeth A Atch ison | 2009 | Am J Clin Nutr2009，90，： | 1 |
| 17 | Farmers’ Attitudes, Objectives, Behaviors, and Personality Traits: The Edinburgh Study of Decision Making on Farms显示文摘 | Joyce Willock Ian J. Deary Murray M. McGregor Alister Sutherland Gareth Edwards-Jones Oliver Morgan Barry Dent Robert Grieve Gavin Gibson Elizabeth Austin | 1999 | Journal of Vocational Behavior1999，，1： | 1 |
| 18 | Corn as a production system for human and animal vaccines显示文摘 | Stephen J Streatfield Jeffrey R Lane Christopher A Brooks Donna K Barker Miranda L Poage Jocelyne M Mayor Barry J Lamphear Carol F Drees Joseph M Jilka Elizabeth E Hood John A Howard | 2002 | Vaccine2002，，7： | 1 |
| 19 | Design and the management of multi-institutional research collaborations: Theoretical implications from two case studies显示文摘 | Corley Elizabeth A Craig Boardman P Barry Bozeman | 2006 | Research Policy2006，，09： | 1 |
| 20 | Factor Analysis of the Zung Self-Rating Depression Scale in a Large Ambulatory Oncology Sample显示文摘 | Steven D. Passik Jeremy C. Lundberg Barry Rosenfeld Kenneth L. Kirsh Kathleen Donaghy Dale Theobald Elizabeth Lundberg William Dugan | 2011 | Psychosomatics2011，，2： | 1 |
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