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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Inguinal cord lipomas显示文摘 | Carilli S Alper A Emer A | 2004 | Hemia2004，8，3： | 1 |
| 3 | Converting Thread-Level Parallelism into Instruction Level Parallelism via Simultaneous Multithreading显示文摘 | Lo J L Eggers S J Emer J S | 1997 | ACM Trans on Computer Systems1997，15，3： | 1 |
| 4 | Simultaneous Multithreading: a Platform for Next-Generation Proeessors显示文摘 | Eggers S J Emer J S Levy H M | 1997 | IEEE Micro1997，17，5： | 1 |
| 5 | Meta-anal-ysis t excess mortality after hip fracture among older womenand men显示文摘 | Haentjens P Magaziner J Colon Emeric C S | 2010 | Ann Intern Med2010，152，： | 1 |
| 6 | Zoledronic Acid in Reducing Clinical Fracture and Mortality after Hip Fracture 显示文摘 | LYLES K W COLON EMERIC C S MAGAZINER J S | 2007 | N EnglJ Med2007，357，40： | 1 |
| 7 | Asim: A Performance Model Framework 显示文摘 | J Emer P Ahuja E Botch A Klauser C K Luk S Manne S S Mukherjee H Patil S Wallace N Binkert R Espasa T Juan | 2002 | Computer (S0018-9162)2002，35，2： | 1 |
| 8 | Polyaniline Solution, Film and Oxidation State 显示文摘 | Angelopoulos M Astunas G E Emer S P | 1988 | Molcryst1988，160，1： | 1 |
| 9 | Performance of the VAX-11/780 translation buffer:Simulation and measurement显示文摘 | Douglas W Clark Joel S Emer | 1985 | ACM Transactions on Computer Systems(TOCS)1985，3，1： | 1 |
| 10 | Converting Thread-Level Parallelism to Instruction-Level Parallelism via Simultaneous Multithreading显示文摘 | Lo J L Eggers J Emer J S | 1997 | ACM Trans on Computer Systems1997，15，3： | 1 |
| 11 | Simultaneous multithreading: a platform for next-generation processors显示文摘 | EGGEGS S J EMER J S LEVY H M LO J L STAMM R L TULLSEN D M | 1997 | IEEE Micro1997，17，5： | 1 |
| 12 | Polyaniline soluetion, film and oxidation state显示文摘 | Angelopoulos M Astunas G E Emer S P | 1988 | Molcryst1988，160，： | 1 |
| 13 | Computing accurate AVFs using ACE analysis on performance models: A rebuttal 显示文摘 | BISWAS A RACUNAS P EMER J MUKHERJEE S S | 2008 | IEEE Computer Architecture Letters2008，7，1： | 1 |
| 14 | Polyaniline solution, film and oxidation state显示文摘 | Angelopoulos M Astunas G E Emer S P | 1988 | Mol Cryst1988，160，： | 1 |
| 15 | The pricing ofstructured products in Germany 显示文摘 | Wilkens S Emer C Roder K | 2003 | The Journal of Deriva-tives2003，11，1： | 1 |
| 16 | Polyaniline Soluetion, film and Oxidation state显示文摘 | Angelopoulos M Astunas G E Emer S P | 1988 | Molcryst1988，160，： | 1 |
| 17 | Simultaneous multithreading:A platform fornext-generation processors显示文摘 | EGGERS S J EMER J S LEVY H M | 1997 | IEEE Micro1997，17，5： | 1 |
| 18 | Polyaniline solution,film and oxidation state显示文摘 | Angelopoulos M Astunas G E Emer S P | 1988 | Mol Cryst1988，160，： | 1 |
| 19 | Steroid-sparing properties of emollients in dermatology 显示文摘 | Harcharik S Emer J | 2014 | Skin Therapy Lett2014，19，1： | 1 |
| 20 | A laboratory experiment demon- strating the dynamic character of membranes 显示文摘 | PUGH M E EMERIC S | 2000 | Bio- chem Mol Biol Edu2000，28，6： | 1 |
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