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| 1 | 患者肠道微生物群失调与肠上皮屏障功能障碍显示文摘最近的证据表明,在动物模型中,肠道病理学和微生物组与高血压之间存在联系。然而,这种关联在人类中是否存在尚不清楚。因此,该研究的目的是检验高血压患者具有明显特异的肠道微生物组以及肠上皮屏障功能标记物和微生物组组成可以预测收缩压变化的假设。研究者通过鸟枪法宏基因组学分析粪便样本显示微生物分类和功能变化,结果显示高血压患者和对照受试者之间丁酸盐产生存在差异。 | Kim S Goel R Kumar A Qi Y Lobaton G Hosaka K Mohammed M Handberg EM Richards EM Pepine CJ Raizada MK 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 45 |
| 2 | Evaluation of quantitative contrast harmonic imaging to assess malignancy of liver tumors:A prospective controlled two-center study显示文摘AIM: To establish the extent to which contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics facilitates the detection of hepatic tumors. METHODS: One hundred patients with histologically confirmed malignant or benign hepatic tumor (maximum size 5 cm) were analyzed. Contrast-enhanced ultrasound (bolus injection 2.5 mL SonoVue) was carried out with intermittent breath-holding technique using a multifrequency transducer (2.5-4 MHz). Native vascularization was analyzed with power Doppler. The contrast-enhanced dynamic ultrasound investigation was carried out with contrast harmonic imaging in true detection mode during the arterial,portal venous and late phases. Mechanical index was set at 0.15. Perfusion analysis was performed by post-processing of the raw data time intensity curve (TIC) analysis. The cut-off of the gray value differences between tumor and normal liver tissue was established using Receiver Operating Characteristic (ROC) analysis 64-line multi-slice computed tomography served as reference method in all cases. Magnetic resonance tomography was used additionally in 19 cases. RESULTS: One hundred patients with 59 malignant (43 colon,5 breast,2 endocrine metastases,7 hepatocellular carcinomas and 2 kidney cancers) and 41 benign (15 hemangiomas,7 focal nodular hyperplasias,5 complicated cysts,2 abscesses and 12 circumscribed fatty changes) tumors were included. The late venous phase proved to be the most sensitive for classification of the tumor type. Fifty-eight of the 59 malignant tumors were classified as true positive,and one as false negative. This resulted in a sensitivity of 98.3%. Of the 41 benign tumors,37 were classified as true negative and 4 as false negative,which corresponds to a specificity of 90.2%. Altogether,95.0% of the diagnoses were classified as correct on the basis of the histological classification. No investigator-dependency (P = 0.23) was noted. CONCLUSION: The results show the possibility of accurate prediction of malignancy of hepatic tumors with a positive prognostic value of 93.5% using advanced contrast-enhanced ultrasound. Contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics is a valuable tool to discriminate hepatic tumors. | EM Jung DA Clevert AG Schreyer S Schmitt J Rennert R Kubale S Feuerbach F Jung | 2007 | World Journal of Gastroenterology2007，13，47： | 15 |
| 3 | 罹患高血压的非洲裔美国人和美国白人的肠道微生物群及血清代谢物差异显示文摘非洲裔美国人高血压患病率、严重程度和高血压治疗抵抗均高于美国白人。肠道微生物菌群及其代谢产物的不同可能是造成这种现象的原因。为此,Walejko等收集研究人群的粪便和血液样本分别用于肠道微生物群的全基因组测序(whole genome sequencing,WGS)和血清整体非靶向代谢组学研究,对上述假设进行了验证。 | Walejko JM Kim S Goel R Handberg EM Richards EM Pepine CJ Raizada MK 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 7 |
| 4 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 5 | Learning two-phase microstructure evolution using neural operators and autoencoder architectures显示文摘Phase-field modeling is an effective but computationally expensive method for capturing the mesoscale morphological and microstructure evolution in materials.Hence,fast and generalizable surrogate models are needed to alleviate the cost of computationally taxing processes such as in optimization and design of materials.The intrinsic discontinuous nature of the physical phenomena incurred by the presence of sharp phase boundaries makes the training of the surrogate model cumbersome.We develop a framework that integrates a convolutional autoencoder architecture with a deep neural operator(DeepONet)to learn the dynamic evolution of a two-phase mixture and accelerate time-to-solution in predicting the microstructure evolution.We utilize the convolutional autoencoder to provide a compact representation of the microstructure data in a low-dimensional latent space.After DeepONet is trained in the latent space,it can be used to replace the high-fidelity phase-field numerical solver in interpolation tasks or to accelerate the numerical solver in extrapolation tasks. | Vivek Oommen Khemraj Shukla Somdatta Goswami Rémi Dingreville George Em Karniadakis | 2022 | npj Computational Materials2022，，1： | 2 |
| 6 | Differential D1 dephos- phorytation in functional and photodamaged photosystem Ⅱ centers显示文摘 | Rintam! ki E Kettunen R Aro EM | 1996 | J Biol Chem1996，271，14： | 1 |
| 7 | Breast cancer in a patient with silicone breast implants after 13 years显示文摘 | Bingham HG Copeland EM Hackerr R | 1988 | Ann Plast Surg1988，20，8： | 1 |
| 8 | Taking standardized patient-based examinations to the next level显示文摘 | Em Ⅱ R | 2004 | Teaching & Learning in Medicine2004，，1： | 1 |
| 9 | Prevalence of post-stroke de-pression in an Irish sample and its relationship with disability and outcome following inpatient rehabilitation显示文摘 | Cassidy EM O' Connor R O' Keane V | 2004 | Disability & Rehabili- tation2004，26，2： | 1 |
| 10 | Chemotherapy- phased hnatinib pulses improve long-term outcome of adlut patients with Philadelphia chromosome-positive acute lymphoblastic leukemia: Northern Italy leukemia group protocol 09/00 显示文摘 | Bassan R Rossi G Pogliani EM | 2010 | J Clin Oncol2010，28，22： | 1 |
| 11 | New perspectives on a subclinical from visceral leishmaniasis显示文摘 | Badaro R Jones TC Carvalho EM | 1986 | J Infect Dis1986，154，6： | 1 |
| 12 | Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution显示文摘 | Rice CM Lenches EM Eddy S R | 1985 | Science1985，229，： | 1 |
| 13 | Diminished expression of S100A2,a putative tumor suppressor,at early stage of human lung carcinogenesis显示文摘 | Feng G Xu X Youssef EM Lotan R | | 0，，： | 1 |
| 14 | Diagnosis of prospective malignancy in koilocytic dysplasias of the cervix with DNA cytometry 显示文摘 | Chatelain R Schunck T Schindler EM | 1989 | J Reprod Med1989，34，8： | 1 |
| 15 | Cytomegalovirus in pregnancy:to screen or not to screen显示文摘 | Walker SP Palma-Dias R Wood EM | 2013 | BMCPregnancy Childbirth2013，13，： | 1 |
| 16 | Plasmonic DNA-orlgami nanoantennas for surface-enhanced Raman spectroscopy 显示文摘 | Kuhler P Roller EM Schreiber R | 2014 | Nano Lett2014，14，5： | 1 |
| 17 | A multi-analytical platform approach to the metabonomic analysis of plasma from normal and Zucker (fa/fa) obese rats显示文摘 | Williams R Lenz EM Wilson AJ | 2006 | Mol Biosyst2006，2，34： | 1 |
| 18 | Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling 显示文摘 | Rosen EY Wexler EM Versano R | 2011 | Neuron2011，71，6： | 1 |
| 19 | Absent or low expression of the zeta chain in T cells at the tumor site correlates with poor survival in patients with oral carcinoma 显示文摘 | Reichert TE Day R Wagner EM | 1998 | Cancer Res1998，58，23： | 1 |
| 20 | The Mesorectum in Rectal Canaer Surgery the Cluc to Pehic Rccurence显示文摘 | Husband EM Ryall RDH | 1982 | Br J Surg1982，69，： | 1 |
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