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| 1 | TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization显示文摘皮肤的神经原的发炎(CNI ) 是被导致的发炎(或提高) 在由从感觉神经末端的 neuropeptides 的版本的皮肤。临床的表明主要是象瘙痒和红斑那样的感觉、脉管的混乱。短暂受体潜力 vanilloid 1 并且 ankyrin 1 (TRPV1 和 TRPA1,分别地) 是知道明确地参予疼痛和 CNI 的非选择的阳离子隧道。TRPV1 和 TRPA1 在感觉神经的一个大子集被共同表示,在他们集成众多的有害刺激的地方。两条隧道的表示也在皮肤在感觉神经以外远延长,现在是清楚的,在 keratinocytes,桅杆房间,树枝状的房间,和 endothelial 房间也发生。在这些 non-neuronal 房间, TRPV1 和 TRPA1 也充当 nociceptive 传感器并且加强煽动性的过程。这评论在在感觉神经原和 non-neuronal 皮肤房间导致或维持 CNI 的煽动性的基因的调整讨论 TRPV1 和 TRPA1 的角色。另外,这评论由支持 CNI 的自我维护的另外的内长的煽动性的调停人提供关于两条 TRP 隧道的细胞内部的促进感受性小径的当前的研究的一篇摘要。 | Olivier Gouin Killian L'Herondelle Nicolas Lebonvallet Christelle Le Gall-lanotto Mehdi Sakka Virginie Buhe Emmanuelle PIee-Gautier Jean-Luc Carre Luc Lefeuvre Laurent Misery~,Raphaele Le Garrec | 2017 | Protein & Cell2017，8，9： | 45 |
| 2 | Albumin liver dialysis as pregnancy-saving procedure in cholestatic liver disease and intractable pruritus显示文摘Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare cholestatic liver disease. Such liver disease can get worse by female hormone disorder. Albumin dialysis or Molecular Adsorbent Recirculating System (MARS) has been reported to reverse severe cholestasis-linked pruritus. Here, we report the first use of MARS during a spontaneous pregnancy and its successful outcome in a patient with PFIC3 and intractable pruritus. Albumin dialysis could be considered as a pregnancy-saving procedure in pregnant women with severe cholestasis and refractory pruritus. | Maud Lemoine Aurélie Revaux Claire Francoz Guillaume Ducarme Sabine Brechignac Emmanuel Jacquemin Michèle Uzan Nathalie Ganne-Carrié | 2008 | World Journal of Gastroenterology2008，14，42： | 14 |
| 3 | Endocrine disrupting chemicals in mixture and obesity,diabetes and related metabolic disorders显示文摘Obesity and associated metabolic disorders represent a major societal challenge in health and quality of life with large psychological consequences in addition to physical disabilities. They are also one of the leading causes of morbidity and mortality. Although, different etiologic factors including excessive food intake and reduced physical activity have been well identified, they cannot explain the kinetics of epidemic evolution of obesity and diabetes with prevalence rates reaching pandemic proportions. Interestingly, convincing data have shown that environmental pollutants, specifically those endowed with endocrine disrupting activities, could contribute to the etiology of these multifactorial metabolic disorders. Within this review, we will recapitulate characteristics of endocrine disruption. We will demonstrate that metabolic disorders could originate from endocrine disruption with a particular focus on convincing data from the literature. Eventually, we will present how handling an original mouse model of chronic exposition to a mixture of pollutants allowed demonstrating that a mixture of pollutants each at doses beyond their active dose could induce substantial deleterious effects on several metabolic end-points. This proof-of-concept study, as well as other studies on mixtures of pollutants, stresses the needs for revisiting the current threshold model used in risk assessment which does not take into account potential effects of mixtures containing pollutants at environmental doses, e.g., the real life exposure. Certainly, more studies are necessary to better determine the nature of the chemicals to which humans are exposed and at which level, and their health impact. As well, research studies on substitute products are essential to identify harmless molecules. | Brigitte Le Magueresse-Battistoni Emmanuel Labaronne Hubert Vidal Danielle Naville | 2017 | World Journal of Biological Chemistry2017，8，2： | 4 |
| 4 | Impact of Metformin on the Prognosis of Cirrhosis Induced by Viral Hepatitis C in Diabetic Patients显示文摘 | Gisèle Nkontchou Emmanuel Cosson Mounir Aout Amel Mahmoudi Valérie Bourcier Iliass Charif Nathalie Ganne-Carrie Véronique Grando-Lemaire Eric Vicaut Jean-Claude Trinchet Michel Beaugrand | 2011 | The Journal of Clinical Endocrinology & Metabolism2011，，8： | 3 |
| 5 | Saccharomyces boulardii Does Not Prevent Relapse of Crohn’s Disease显示文摘 | Arnaud Bourreille Guillaume Cadiot Gérard Le Dreau David Laharie Laurent Beaugerie Jean–Louis Dupas Philippe Marteau Patrick Rampal Dominique Moyse Ashraf Saleh Marie–Emmanuelle Le Guern Jean–Paul Galmiche | 2013 | Clinical Gastroenterology and Hepatology2013，，8： | 3 |
| 6 | Gut microbiome in allogeneic hematopoietic stem cell transplantation and specific changes associated with acute graft vs host disease显示文摘Allogeneic hematopoietic stem cell transplantation(aHSCT)is a standard validated therapy for patients suffering from malignant and nonmalignant hematological diseases.However,aHSCT procedures are limited by potentially life-threatening complications,and one of the most serious complications is acute graft-versus-host disease(GVHD).During the last decades,DNA sequencing technologies were used to investigate relationship between composition or function of the gut microbiome and disease states.Even if it remains unclear whether these microbiome alterations are causative or secondary to the presence of the disease,they may be useful for diagnosis,prevention and therapy in aHSCT recipients.Here,we summarized the most recent findings of the association between human gut microbiome changes and acute GVHD in patients receiving aHSCT. | Quentin Le Bastard Patrice Chevallier Emmanuel Montassier | 2021 | World Journal of Gastroenterology2021，27，45： | 2 |
| 7 | Value of pelvic embolization in the management of severe postpartum hemorrhage due to placenta accreta, increta or percreta显示文摘 | Philippe Soyer Olivier Morel Yann Fargeaudou Marc Sirol Fabrice Staub Mourad Boudiaf Henri Dahan Alexandre Mebazaa Emmanuel Barranger Olivier le Dref | 2010 | European Journal of Radiology2010，，3： | 2 |
| 8 | The wide spectrum of multidrug resistance 3 deficiency: From neonatal cholestasis to cirrhosis of adulthood显示文摘 | Emmanuel Jacquemin J. Marleen L. De Vree Danièle Cresteil Etienne M. Sokal Ekkehard Sturm Micheline Dumont George L. Scheffer Marianne Paul Martin Burdelski Piter J. Bosma Olivier Bernard Michelle Hadchouel Ronald P.J. Oude Elferink | 2001 | Gastroenterology2001，，6： | 2 |
| 9 | A high-fatdiet impairs cardiac high-energy phosphate metabolismand cognitive function in healthy human subjects显示文摘 | Holloway CJ Cochlin LE Emmanuel Y | 2011 | Am JClin Nutr2011，93，4： | 1 |
| 10 | Genetic differences for nitrogen uptake and nitrogen utilisation efficiencies in winter wheat显示文摘 | Jacques Le Gouis Denis Béghin Emmanuel Heumez Pierre Pluchard | 2000 | European Journal of Agronomy2000，，3： | 1 |
| 11 | Transcriptional Activation of Apolipoprotein CIII Expression by Glucose May Contribute to Diabetic Dyslipidemia显示文摘 | Sandrine Caron An Verrijken Ilse Mertens Carolina Huaman Samanez Gisèle Mautino Joel T. Haas Daniel Duran-Sandoval Janne Prawitt Sven Francque Emmanuelle Vallez Anne Muhr-Tailleux Isabelle Berard Folkert Kuipers Jan A. Kuivenhoven Sudha B. Biddinger Marja | 2011 | Arteriosclerosis Thrombosis and Vascular Biology2011，，3： | 1 |
| 12 | Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients显示文摘 | Fran?ois Ghiringhelli Cedric Menard Pierre Emmanuel Puig Sylvain Ladoire Stephan Roux Fran?ois Martin Eric Solary Axel Le Cesne Laurence Zitvogel Bruno Chauffert | 2007 | Cancer Immunology Immunotherapy2007，，5： | 1 |
| 13 | Outcome and Cost Analysis of Sacral Nerve Modulation for Treating Urinary and/or Fecal Incontinence显示文摘 | Anne-Marie Leroi Xavier Lenne Beno?t Dervaux Emmanuel Chartier-Kastler Brigitte Mauroy Lo?c Le Normand Philippe Grise Jean-Luc Faucheron Yann Parc Paul-Antoine Lehur Fran?ois Mion Henri Damon Xavier Barth Albert Leriche Christian Saussine Laurent Guy Fran | 2011 | Annals of Surgery2011，，4： | 1 |
| 14 | Genetic differences for nitrogen uptake and nitrogen utilisation efficiencies in winter wheat显示文摘 | Jacques Le Gouis Denis Béghin Emmanuel Heumez Pierre Pluchard | 2000 | European Journal of Agronomy2000，，3： | 1 |
| 15 | Accuracy of multislice computed tomography in the preoperative assessment of coronary disease in patients scheduled for heart valve surgery显示文摘 | Réda Jakamy Olivier Barthélémy Claude Le Feuvre Emmanuel Berman Rhéda Boutekadjirt Philippe Cluzel Jean-Philippe Metzger Gérard Helft | 2012 | 2012 (8-9)2012，，8： | 1 |
| 16 | Sorafenib in patients with progressive epithelioid hemangioendothelioma显示文摘 | Christine Chevreau Axel Le Cesne Isabelle Ray‐Coquard Antoine Italiano Angela Cioffi Nicolas Isambert Yves Marie Robin Charles Fournier Stéphanie Clisant Loic Chaigneau Jacques‐Olivier Bay Emmanuelle Bompas Eric Gauthier Jean Y. Blay Nicolas Penel | 2013 | Cancer2013，，14： | 1 |
| 17 | Influence of Surgical Margins on Outcome in Patients With Intrahepatic Cholangiocarcinoma: A Multicenter Study by the AFC-IHCC-2009 Study Group显示文摘 | Olivier Farges David Fuks Emmanuel Boleslawski Yves-Patrice Le Treut Denis Castaing Alexis Laurent Christian Ducerf Michel Rivoire Philippe Bachellier Laurence Chiche Gennaro Nuzzo Jean Marc Regimbeau | 2011 | Annals of Surgery2011，，5： | 1 |
| 18 | Value of pelvic embolization in the management of severe postpartum hemorrhage due to placenta accreta, increta or percreta显示文摘 | Philippe Soyer Olivier Morel Yann Fargeaudou Marc Sirol Fabrice Staub Mourad Boudiaf Henri Dahan Alexandre Mebazaa Emmanuel Barranger Olivier le Dref | 2010 | European Journal of Radiology2010，，3： | 1 |
| 19 | Low-P tolerance by maize (Zea mays L.) genotypes: Significance of root growth, and organic acids and acid phosphatase root exudation显示文摘 | Alain Gaume Felix M?chler Carlos De León Luis Narro Emmanuel Frossard | 2001 | Plant and Soil2001，，2： | 1 |
| 20 | Peliosis hepatis with initial presentation as acute hepatic failure and intraperitoneal hemorrhage in children显示文摘 | Emmanuel Jacquemin Danièle Pariente Monique Fabre Gilbert Huault Jacques Valayer Olivier Bernard | 1999 | Journal of Hepatology1999，，6： | 1 |
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