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| 1 | Endometrial mesenchymal stem cells as a cell based therapy for pelvic organ prolapse显示文摘Pelvic organ prolapse(POP) occurs when the pelvic organs(bladder, bowel or uterus) herniate into the vagina, causing incontinence, voiding, bowel and sexual dysfunction, negatively impacting upon a woman's quality of life. POP affects 25% of all women and results from childbirth injury. For 19% of all women, surgical reconstructive surgery is required for treatment, often augmented with surgical mesh. The surgical treatment fails in up to 30% of cases or results in adverse effects, such as pain and mesh erosion into the bladder, bowel or vagina. Due to these complications the Food and Drug Administration cautioned against the use of vaginal mesh and several major brands have been recently been withdrawn from market. In this review we will discuss new cell-based approaches being developed for the treatment of POP. Several cell types have been investigated in animal models, including a new source of mesenchymal stem/stromal cells(MSC) derived from human endometrium. The unique characteristics of endometrial MSC, methods for their isolation and purification and steps towards their development for good manufacturing practice production will be described. Animal models that could be used to examine the potential for this approach will also be discussed as will a rodent model showing promise in developing an endometrial MSC-based therapy for POP. The development of a preclinical large animal model for assessing tissue engineering constructs for treating POP will also be mentioned. | Stuart J Emmerson Caroline E Gargett | 2016 | World Journal of Stem Cells2016，8，5： | 10 |
| 2 | Reduction of the closure time of postoperative enterocutaneous fistulas with fibrin sealant显示文摘AIM: To assess whether the use of fibrin sealantshortens the closure time of postoperative enterocutaneous fistulas (ECFs). METHODS: The prospective case-control study included 70 patients with postoperative ECFs with an output of < 500 mL/d, a fistulous tract of > 2 cm and without any local complication. They were divided into study (n = 23) and control groups (n = 47). Esophageal, gastric and colocutaneous fistulas were monitored under endoscopic visualization, which also allowed fibrin glue application directly through the external hole. Outcome variables included closure time, time to resume oral feeding and morbidity related to nutritional support. RESULTS: There were no differences in mean age, fistula output, and follow-up. Closure-time for all patients of the study group was 12.5 ± 14.2 d and 32.5 ± 17.9 d for the control group (P < 0.001), and morbidity related to nutritional support was 8.6% and 42.5%, respectively (P < 0.01). In patients with colonic fistulas, complete closure occurred 23.5 ± 19.5 d after the first application of fibrin glue, and spontaneous closure was observed after 36.2 ± 22.8 d in the control group (P = 0.36). Recurrences were observed in 2 patients because of residual disease. One patient of each group died during follow-up as a consequence of septic complications related to parenteral nutrition. CONCLUSION: Closure time was significantly reduced with the use of fibrin sealant, and oral feeding was resumed faster. We suggest the use of fibrin sealant for the management of stable enterocutaneous fistulas. | Jorge Avalos-González Eliseo Portilla-deBuen Caridad Aurea Leal-Cortés Abel Orozco-Mosqueda María del Carmen Estrada-Aguilar Gabriela Abigail Velázquez-Ramírez Gabriela Ambriz-González Clotilde Fuentes-Orozco Aldo Emmerson Guzmán-Gurrola Alejandro González-Ojeda | 2010 | World Journal of Gastroenterology2010，16，22： | 10 |
| 3 | 头孢呋新酯显示文摘头孢呋新(ce furoxi me)为注射用第二代头孢菌素。它体外抗菌活性很强,对肠道细菌产的β内酰胺酶稳定性高,且药代动力学特征良好。因为它在生理pH时高度离解,脂溶性差,基本上口服不吸收。头孢呋新酯(Cefuroxime axe(?)l)为头孢呋新前体药,在头孢呋新C4位羧基上发生酯化,从而提高了亲脂性,增加口服后吸收率。头孢呋新酯吸收后仅3~4分钟内在肠粘膜和门循环中迅速水解,去酯分解为头孢呋新、乙醛和乙酸。血循环中测不到头孢呋新酯原药。制剂由于曾存在一些与药物本身理化特性有关的问题,发展头孢呋新酯花了相当长的时间。 | Emmerson AM 陈汉源 | 1989 | 国外医药(抗生素分册)1989，10，5： | 3 |
| 4 | Commercial approaches to genetic selection for growth and feed conversion in domestic poultry 显示文摘 | Emmerson D A | 1997 | Poultry Science1997，76，： | 1 |
| 5 | Effect of estrogen and progesterone on early embryonic mortality in ovariectomized gilts显示文摘 | Day B N Anderson L L Emmerson M A et ol | 1959 | J Anim Sci1959，18，： | 1 |
| 6 | Survivorship analysis of the Kinematic Stabilizer total knee replacement : a 10 - to 14-year follow- up显示文摘 | Emmerson KP Moran CG Pinder IM | 1996 | J Bone Joint Surg Br1996，78，3： | 1 |
| 7 | Fresh osteochondral al- lografts 显示文摘 | Jamali AA Emmerson BC Chung C | 2005 | Clinical Orthopaedics and Related Research2005，437，： | 1 |
| 8 | Geo statistical analysis of sampling uncertainty at the Tollesbury Man aged retrea site in Black-water Estuary, Essex, UK: kriging and cokriging approach to minimize sampling density 显示文摘 | Chang Y H Serimshaw M D Emmerson R H C | | The Sci ence of0，，： | 1 |
| 9 | Nucleotide sequence of the fusion and hemagglutinin-neuraminidase glycoprotein genes of Newcastle disease virus,strain Ulster:molecular basis for variations in pathogenicity between strains显示文摘 | Millar N S Chambers P Emmerson P T | 1988 | J Gen Virol1988，69，： | 1 |
| 10 | Physical activity, age, and cagnitive-neuropsycholagical function 显示文摘 | Dustman RE Emmerson R Shearer D | 1994 | J Aging Phys Act1994，2，： | 1 |
| 11 | Nucleotide sequence of the fusion and haemaglutinin-neuram inidase glycoprotein genes of Newcastle disease virus,strain ulster molecular basis for variation in pathogenicity between strains显示文摘 | MILLAR N S CHAMBERS P EMMERSON P T | 1988 | J Gen Virol1988，69，： | 1 |
| 12 | Induced maturation of prawn Penaeus indicus 显示文摘 | Emmerson W D | 1980 | Marine Ecology Progress Series1980，，2： | 1 |
| 13 | Developmental Regulation of Nutrient Transporter and Enzyme mRNA Abundance in the Small Intestine of Broilers 显示文摘 | Gilbert E R Li H Emmerson D A | 2007 | Poult Sci2007，86，8： | 1 |
| 14 | Role of apoptotie and matrix- degrading genes in articular cartilage and meniscus of mature and aged rabbits during development of osteoarthritis 显示文摘 | Pennock AT Robertson CM Emmerson BC | 2007 | Arthritis Rheum2007，56，5： | 1 |
| 15 | Effect of oral fructose on urate production 显示文摘 | Emmerson BT | 1974 | Ann Rheum Dis1974，33，： | 1 |
| 16 | Life span changes in electrophysiological measures of inhibition 显示文摘 | Dustman RE Emmerson RY Shearer DE | 1996 | Brain Cogn1996，30，： | 1 |
| 17 | Geostatistical analysis of sampling uncertainty at the Tollesbury Managed Retreat site in Black water Estuary, Essex, UK: Kriging and cokriging approach to minimize sampling density 显示文摘 | Chang Y H Scrimshaw M D Emmerson R H C | 1998 | The Science of the Total Environment1998，221，： | 1 |
| 18 | The role of estrogen deficien- cy in skin ageing and wound healing 显示文摘 | Emmerson E Hardman MJ | 2011 | Biogerontology2011，3，4： | 1 |
| 19 | Induced maturation of prawn Penaeus indicus显示文摘 | Emmerson W D | 1980 | Marine Ecology Progress Series1980，2，2： | 1 |
| 20 | Nucleotide sequence analysis of the haemagglutinin-neuraminidase gene of Newcastle disease virus显示文摘 | Millar N S Chambers P Emmerson P T | 1986 | Journal of General Virology1986，67，： | 1 |
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