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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Pain in youths with neuromuscular disease显示文摘 | ENGEL JM KARTIN D CARTER G T | 2009 | Am J Hosp Palliat Care2009，26，5： | 1 |
| 3 | A combined OFDM/SDMA approach 显示文摘 | Perre L V D Engels M G E | 2000 | IEEE J Select Areas Commun2000，18，11： | 1 |
| 4 | Advances in the study of high intensity conditioning as a means of improving mineral flotation performance 显示文摘 | ENGEL M D MIDDLEBROOK P D JAMESON G J | 1997 | Minerals Engineering1997，10，1： | 1 |
| 5 | Cbanges of cerebral biood flow during the secondary expansion of a cortical contusion assessed by 14C- iodoantiphrine in mice using a non-invaaive protocol显示文摘 | Engel D C Mies G Terpolilli N A | 2008 | Neurotrauma2008，25，7： | 1 |
| 6 | Histopathological studiesof staphylococcal alpha-toxin: effects on rabbit corneas显示文摘 | Moreau J M Sloop G D Engel L S | 1997 | Curr EyeRes1997，，16： | 1 |
| 7 | The earliest pathologic alterations in dysferlinopathy 显示文摘 | Selcen D Stilling G Engel AG | 2001 | Neurology2001，1256，11： | 1 |
| 8 | Develop- ment and psychometric validation of an eating disorder- specific health-related quality of life instrument显示文摘 | Engel S G Wittrock D A Crosby R D | 2006 | Int J Eat Disord2006，39，1： | 1 |
| 9 | Tficlabendazole for the treatment of fascioliasis and paragonimiasis 显示文摘 | Keiser J Engels D Buscher G | 2005 | Expert Opin Investig Drags2005，14，12： | 1 |
| 10 | Techniques for scheduling with rejection 显示文摘 | Engels D W Karger D R Kolliopoulos S G | 2003 | Journal of Algorithms2003，49，1： | 1 |
| 11 | Advances in the study of high intensity conditioning as-ameans of improving mineral flotation performance 显示文摘 | Engel M D Middlebrook Jameson G J | 1997 | Minerals Engineering1997，10，1： | 1 |
| 12 | Histopatho-logicai studies of staphylococcal alpha-toxin: effectson rabbit corneas 显示文摘 | Moreau J M Sloop G D Engel L S | 1997 | Curr Eye Res1997，16，12： | 1 |
| 13 | Techniques for scheduling with rejection 显示文摘 | Engels D W Karger D R Kolliopoulos S G | 2003 | Journal of Algorithms2003，49，： | 1 |
| 14 | The pulsed dis- charge arc resistance and its functional behavior 显示文摘 | Engel T G Anthony L D Magne K | 1989 | IEEE Transactions on Plasma Science1989，17，2： | 1 |
| 15 | Pain in youths with neuromuscular disease显示文摘 | ENGEL J M KARTIN D CARTER G T | 2009 | Am J Hosp Palliat Care2009，26，5： | 1 |
| 16 | Mutations in MyoTilin cause myofibrillar myopathy显示文摘 | SELCEN D ENGEL A G | 2004 | Neurology2004，62，8： | 1 |
| 17 | Prognostic value of sec- ondary insults in traumatic brain injury: results from the IMPACT study显示文摘 | McHugh G S Engel D C Butcher I | 2007 | J Neurotrauma2007，24，2： | 1 |
| 18 | Techniques for scheduling with rejection显示文摘 | Engels D W Karger D R Kolliopoulos S G | 2003 | Journal of Algorithms2003，49，1： | 1 |
| 19 | Imaging purple membrane in aqueous solution at sub-nanometer resolution by atomic force microscopy显示文摘 | Müller D J Schabert F A Büldt G Engel A | 1995 | Biophys J1995，68，： | 1 |
| 20 | Automatic control of pressure support for ventilator weaning in surgical intensive care patients 显示文摘 | Schadler D Engel C Elke G | 2012 | Am J Respir Crit Care Med2012，185，6： | 1 |
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