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| 1 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 2 | Management of digestive bleeding related to portal hypertension in cirrhotic patients:A French multicenter cross-sectional practice survey显示文摘AIM: To investigate the conformity of management practices of gastrointestinal hemorrhage in cirrhotic patients with relevant guidelines. METHODS: A questionnaire on the management of digestive bleeding was completed for all consecutive cirrhotic patients admitted to 31 French hospitals. RESULTS: One hundred and twenty-six bleeding events were recorded. It was the first bleeding episode in 79 patients (63%), of whom 40 (51%) had a prior diagnosis of cirrhosis and 25 (32%) had previously undergone an endoscopy. The bleeding episode was a recurrence in 46 patients (37%). The median time between onset and admission was 4 h, but exceeded 12 h in 42% of cases. There was an agreement between centers forearly vasoactive drug administration (87% of cases), association with ligation (42%) more often than sclerosis (21%) at initial endoscopy, and antibiotic prophylaxis (64%). By contrast, prescription of beta-blockade alone or in combination (0 to 100%, P = 0.003) for secondary prophylaxis and lactulose (26% to 86%, P = 0.04), differed among centers. CONCLUSION: In French hospitals, management of bleeding related to portal hypertension in cirrhotic patients is generally in keeping with the consensus. Broad variability still remains concerning beta-blockade use for secondary prophylaxis. Screening for esophageal varices, the use of antibiotic prophylaxis and patients information need to be improved. | Pierre Ingrand Jérme Gournay Pierre Bernard Frédéric Oberti Brigitte Bernard-Chabert Arnault Pauwels Philippe Renard Eric Bartoli Jean-Franois Cadranel Jean-Claude Barbare Isabelle Ingrand Michel Beauchant | 2006 | World Journal of Gastroenterology2006，12，48： | 4 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 4 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 5 | Differential relations between general cognitive ability and interest-vocation fit 显示文摘 | CHARLIE L R ERIC D H | 2004 | Journal of Occupational and Organizational Psychology2004，，77： | 1 |
| 6 | Finite element modelling of exural behaviour of externally bonded CFRP reinforced concrete structures显示文摘 | EMMANUELLE D ERIC R | 2002 | Engineering Structures2002，，24： | 1 |
| 7 | A Survey of AntiTamper Technologies显示文摘 | Mikhail J Atallah Eric D Bryant Martin R Stytz | 2004 | CROSSTALK:The Journal of Defense Software Engineering2004，17，11： | 1 |
| 8 | Base station location and channel allocation in a cellular network with emergency coverage requirements显示文摘 | MOHAN R A RAJAN B ERIC M D | 2005 | European J of Operational Research2005，164，2： | 1 |
| 9 | Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling显示文摘 | ASH A A MICHAEL B E ERIC R D | 2000 | Nature2000，403，4： | 1 |
| 10 | Review-Animal Waste Used as Livestock Feed:Dangers to Human Health显示文摘 | Eric R Haapapuro Neal D Barnard | 1997 | Preventive medicine1997，26，： | 1 |
| 11 | Synthesis and ceramic conversion ceactions of pinacol- borane-and diethylborazine-modified poly ( vinylsilox- ane) s The development of a processable single-source polymeric precursor to Boron-modified silicon carbide 显示文摘 | BRUNNER A R BUJALSKI D R ERIC S | 2000 | Chem Mater2000，，12： | 1 |
| 12 | Long- range oxidation of guanine by Ru (111) in duplex DNA 显示文摘 | Michelle R A Eric D A S Sabine C P | 1997 | Chem Biol1997，4，： | 1 |
| 13 | Pharmacogenetic Association of the NPPA T2238C Genetic Variant With Cardiovascular Disease Outcomes in Patients With Hypertension 显示文摘 | Amy I L Eric B Barry R D et aI | 2008 | JAMA2008，299，3： | 1 |
| 14 | BAI 3, CDX 2 and VIL 1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas显示文摘 | Muhammad F Bari Helen Brown Andrew G Nicholson Keith M Kerr John R Gosney William A Wallace Irshad Soomro Salli Muller Danielle Peat Jonathan D Moore Lesley A Ward Maxim B Freidin Eric Lim Manu Vatish David R J Snead | 2014 | Histopathology2014，，： | 1 |
| 15 | Thermal Analysis of Automotive Lamps Using the ADINA-F Coupled Specular Radiation and Natural Convection Model显示文摘 | William I M Eric S D Christopher R P | 1999 | Computers & Structures1999，72，1： | 1 |
| 16 | Medical therapy can improve the biological properties of the chronically failing heart显示文摘 | Eric J Eichhorn M D Michael R | 1996 | Circulation1996，194，： | 1 |
| 17 | Liquids′atomization with two different nozzles:modeling of the effects of someproce-ssing and formulation conditions by dimensional analysis显示文摘 | SANDRA M ERIC R GUILLAUME D | 2012 | Powder Technology2012，，224： | 1 |
| 18 | LS14:A novel human adi-pocyte cell line that produces prolactin显示文摘 | Hugo Terry D | 2005 | Endocrinol-ogy2005，9，147： | 1 |
| 19 | Base station location and channel allocation in a cellular network with emergency coverage requirements显示文摘 | Akena M R Rajan B Eric M D | 2005 | European Journal of Operational Researeh2005，，： | 1 |
| 20 | Liquid deposition photolithography for submicrometer resolution three-dimensional index structuring with large throughput显示文摘Photonic devices increasingly require three-dimensional control of refractive index,but existing fabrication methods such as femtosecond micromachining,multilayer lithography and bulk diffusion can only address a select scale range,are often limited in complexity or thickness and have low throughput.We introduce a new fabrication method and polymeric material that can efficiently create mm^(3) optical devices with programmable,gradient index of refraction with arbitrary feature size.Index contrast of 0.1 is demonstrated,which is 100 times larger than femtosecond micromachining,and 20 times larger than commercial holographic photopolymers.This is achieved by repetitive microfluidic layering of a self-developing photopolymer structured by projection lithography.The process has the unusual property that total fabrication time for a fixed thickness decreases with the number of layers,enabling fabrication 10^(5) faster than femtosecond micromachining.We demonstrate the process by sequentially writing 100 layers to fabricate a mm thick waveguide array. | Adam C Urness Eric D Moore Keith K Kamysiak Michael C Cole Robert R McLeod | 2013 | Light(Science & Applications)2013，2，1： | 1 |
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