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| 1 | Tumor Antigen Specific Activation of Primary Human T-Cells Expressing a Virally Encoded Chimeric T-Cell Receptor Specific for p185HER2显示文摘We have developed and tested chimeric T-cell receptors (TCR) specific for p185HER2. In these experiments, retroviral vectors expressing the N29γ or N29ζ receptors were constructed in pRET6. Amphotropic viral producer cells were established in the GALV-based PG13 packaging cell line. Ficoll purified human peripheral blood lymphocytes (PBL) were virally transduced using an optimized protocol incorporating activation with immobilized anti-CD3/anti-CD28 monoclonal anti- bodies, followed by viral infection in the presence of fibronectin fragment CH296. Transduced cells were co-cultured with human tumor cell lines that overexpress (SK-OV-3) or underexpress (MCF7) p185HER2 to assay for antigen specific im- mune responses. Both CM+ and CD8+ T-cells transduced with the N29γ or N29ζ chTCR demonstrated HER2-specific anti- gen responses, as determined by release of Th1 like cytokines, and cellular cytotoxicity assays. Our results support the fea- sibility of adoptive immunotherapy with genetically modified T-cells expressing a chTCR specific for p185HER2. | 杨建民 Michael S FRIEDMAN Christopher M REYNOLDS Marianne T HUBEN Lee WILKE Jennifer FULLER 李桥 Zelig ESHHAR James J MULE Kevin T MCDONAGH | 2004 | Journal of Microbiology and Immunology2004，2，4： | 5 |
| 2 | Functional expression of chimeric receptor genes in human T cells 显示文摘 | Eshhar Z Waks T Bendavid A | 2001 | J Immunol Meth- ods2001，248，12： | 1 |
| 3 | Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibodytype specificity显示文摘 | Gross G Waks T Eshhar Z | 1989 | Proc Natl Acad Sci USA1989，86，10： | 1 |
| 4 | Expression of immunoglobulin-T- cell receptor chimeric molecules as functional receptors withantibodytype specificity显示文摘 | Gross G Waks T Eshhar Z | 1989 | Proc Natl Acad Sci U S A1989，86，10： | 1 |
| 5 | Tumor-specific T-bodies:towards clinical applications显示文摘 | ESHHAR Z | 1997 | Cancer Immunol Immunother1997，45，34： | 1 |
| 6 | The T-body approach: redirecting T cells with antibody specificity显示文摘 | Eshhar Z | 2008 | Handb Exp Pharmacol2008，181，： | 1 |
| 7 | Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity显示文摘 | Gross G Waks T Eshhar Z et aI | 1989 | Proc Natl Acad Sci USA1989，86，10： | 1 |
| 8 | Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibodytype specificity 显示文摘 | Gross G Waks T Eshhar Z | 1989 | Proc Nat! Acad Sci USA1989，86，10： | 1 |
| 9 | Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors显示文摘 | Eshhar Z Waks T Gross G | 1993 | Proc Natl Acad Sci USA1993，90，2： | 1 |
| 10 | Suppression of Human ProstateTumor Growth in Mice by a Cytolytic D-,L-Amino Acid Peptide Membrane Lysis, IncreasedNecrosis,and Inhibition of Prostate-Specific Antigen Secretion显示文摘 | Niv Papo Amir Braunstein Zelig Eshhar | 2004 | Cancer Research2004，15，64： | 1 |
| 11 | Expression of immunoglobulin- T-cell receptor chimeric molecules as functional receptors with antibody-type specificity 显示文摘 | Gross G Waks T Eshhar Z | 1989 | Proc Natl Acad Sci USA1989，86，10： | 1 |
| 12 | Suppression of human prostate tumor growth in mice by a cytolytic D-, L-amino acid peptide: membrane lysis, increased necrosis, and inhibition of prostate-specific antigen secretion 显示文摘 | Papo N Braunstein A Eshhar A | 2004 | Cancer Res2004，64，16： | 1 |
| 13 | Mapping of the high affinity Fc epsilon receptor binding site to the third constant region domain of IgE显示文摘 | Nissim A Jouvin M H Eshhar Z | 1991 | EMBO J1991，10，1： | 1 |
| 14 | Allogeneic chimeric antigen receptor-modified cells for adoptive cell therapy of cancer显示文摘 | Marcus A Eshhar Z | 2014 | Expert Opin Biol Ther2014，14，7： | 1 |
| 15 | Antibodies to gangliosid and myelin autoantigens are produced in mice following sciatic nerve injury 显示文摘 | SCHWARTZ M SELA B A ESHHAR N | 1982 | J Neurochem1982，38，5： | 1 |
| 16 | Expression of immunoglobu- lin-T-cell receptor chimeric molecules as functional recep-tors with antibody-type specificity显示文摘 | Gross G Waks T Eshhar Z | 1989 | Proc Nat1 Acad Sci U S A1989，86，10： | 1 |
| 17 | Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody- type specificity显示文摘 | Gross G Waks T Eshhar Z | 1989 | Proc Natl Acad Sci U S A1989，86，10： | 1 |
| 18 | Expression of immunoglobulin -T- cell receptor chimeric molecules as functional receptors with antibody - type specificity显示文摘 | Gross G Waks T Eshhar Z | 1989 | Proc Natl Acad Sci USA1989，86，10： | 1 |
| 19 | Expression of immunoglobulin-T- cell receptor chimeric molecules as functional receptors with antibody-type specificity显示文摘 | Gross G Waks T Eshhar Z | 1989 | Proc Nat1 Acad Sci U S A1989，86，10： | 1 |
| 20 | Expression of immunoglobulin- T-cell receptor chimeric molecules as functional receptors with anti- body-type specificity 显示文摘 | GROSS G WAKS T ESHHAR Z | 1989 | Proc Natl Acad Sci U S A1989，86，10： | 1 |
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