|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of melatonin on diabetes-related metabolic disorders显示文摘Melatonin is a circulating hormone that is mainly re- leased from the pineal gland. It is best known as a regulator of seasonal and circadian rhythms, its levels being high during the night and low during the day. Interestingly, insulin levels are also adapted to day/night changes through melatonin-dependent synchronization. This regulation may be explained by the inhibiting action of melatonin on insulin release, which is transmitted through both the pertussis-toxin-sensitive membrane receptors MT1 and MT2 and the second messengers 3',5' -cyclic adenosine monophosphate, 3',5'-cyclic guanosine monophosphate and inositol 1,4,5-trisphosphate. Melatonin may influence diabetes and associated metabolic disturbances not only by regulating insulin secretion, but also by providing protection against reactive oxygen species, since pancreatic β-cells are very susceptible to oxidative stress because they possess only low-antioxidative capacity. On the other hand, in several genetic association studies, single nucleotide polymorphysms of the human MT2 receptor have been described as being causally linked to an elevated risk of developing type 2 diabetes. This suggests that these individuals maybe more sensitive to the actions of melatonin, thereby leading to impaired insulin secretion. Therefore, block- ing the melatonin-induced inhibition of insulin secretion may be a novel therapeutic avenue for type 2 diabetes. | Javier Espino José A Pariente Ana B Rodríguez | 2011 | World Journal of Diabetes2011，2，6： | 11 |
| 2 | Management of Helicobacter pylori infection in Latin America: A Delphi technique-based consensus显示文摘AIM: To optimize diagnosis and treatment guidelines for this geographic region, a panel of gastroenterologists, epidemiologists, and basic scientists carried out a structured evaluation of available literature.METHODS: Relevant questions were distributed among the experts, who generated draft statements for consideration by the entire panel. A modified three-round Delphi technique method was used to reach consensus. Critical input was also obtained from representatives of the concerned medical community. The quality of the evidence and level of recommendation supporting each statement was graded according to United States Preventive Services Task Force criteria.RESULTS: A group of ten experts was established. The survey included 15 open-ended questions that were distributed among the experts, who assessed the articles associated with each question. The levels of agreement achieved by the panel were 50% in the first round, 73.3% in the second round and 100% in the third round. Main consensus recommendations included:(1) when available, urea breath and stool antigen test(HpSA) should be used for non-invasive diagnosis;(2) detect and eradicate Helicobacter pylori(H. pylori) in all gastroscopy patients to decrease risk of peptic ulcer disease, prevent o retard progression in patients with preneoplastic lesions, and to prevent recurrence in patients treated for gastric cancer;(3) further investigate implementation issues and health outcomes of H. pylorieradication for primary prevention of gastric cancer in high-risk populations;(4) prescribe standard 14-d triple therapy or sequential therapy for first-line treatment;(5) routinely assess eradication success post-treatment in clinical settings; and(6) select second- and third-line therapies according to antibiotic susceptibility testing.CONCLUSION: These achievable steps toward better region-specific management can be expected to improve clinical health outcomes. | Antonio Rollan Juan Pablo Arab M Constanza Camargo Roberto Candia Paul Harris Catterina Ferreccio Charles S Rabkin Juan Cristóbal Gana Pablo Cortés Rolando Herrero Luisa Durán Apolinaria García Claudio Toledo Alberto Espino Nicole Lustig Alberto Sarfatis Catalina Figueroa Javier Torres Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，31： | 2 |
| 3 | Eco-bio-social determinants of dengue vector breeding: a multicountry study in urban and periurban Asia显示文摘 | Arunachalam Natarajan Tana Susilowati Espino Fe Kittayapong Pattamaporn Abeyewickreme Wimal Wai Khin Thet Tyagi Brij Kishore Kroeger Axel Sommerfeld Johannes Petzold Max | 2010 | World Health Organization Bulletin of the World Health Organization2010，，3： | 2 |
| 4 | Transendoscopic uhrasonography with miniprobes 显示文摘 | Abad R Varas M J Espinos JC | 2001 | Rev Esp Enferm Dig2001，93，4： | 1 |
| 5 | Advanced imaging technologies for the detection of dysplasia and early cancer in barrett esophagus 显示文摘 | Espino A Cirocco M Daeosta R | 2014 | Clin Endosc2014，47，1： | 1 |
| 6 | Entropy analysis of the EEG background activity in Alzheimer' s disease patients显示文摘 | ABASOLO D HORNERO R ESPINO P | 2006 | Physiol Meas2006，27，： | 1 |
| 7 | Preparation of Transparent and Conductive Al-doped ZnO Thin Films by ECR Plasma Enhanced CVD显示文摘 | Martin A Espinos J P Justo A | 2002 | Surface and Coatings Technology2002，，： | 1 |
| 8 | Melatonin potentiates chemotherapy-induced cytotoxicity and apoptosis in rat pancreatic tumor cells显示文摘 | Uguz AC Cig B Espino J | 2012 | J Pineal Res2012，53，1： | 1 |
| 9 | Determination of technical efficiency of fisheries by stochastic frontier models: a case on the Gulf of Cadiz显示文摘 | Hoyo J J Espino D C Toribio R J | 2004 | ICES Journal of Marine Science2004，61，： | 1 |
| 10 | The emerging science of very early detection of disease outbreaks 显示文摘 | Wagner MM Tsui F Espino JU | 2001 | J Public Health Management Practice2001，7，： | 1 |
| 11 | Preservation of seagrassclonal integration buffers against burial stress 显示文摘 | Tuya F Espino F Terrados J | 2013 | J ExpMar Biol Ecol2013，439，： | 1 |
| 12 | Isolation and characterization of cellulose nanocrystals from industrial by-products of Agave tequilana and barley显示文摘 | Etzael Espino Mélissa Cakir Sandra Domenek Alma Delia Román-Gutiérrez Naceur Belgacem Julien Bras | 2014 | Industrial Crops & Products2014，，： | 1 |
| 13 | Cerebrospinal dopamine metabolites in rats after intrastriatal administration of 6-hydroxydopamine or 1-methyl-4-phenyl-1,2,3,6-tetrahydrophridine显示文摘 | Espino A Liorens J Calopa M | 1995 | Brain Res1995，669，： | 1 |
| 14 | Ion Beam Induced Chemical Vapor Deposition for The Preparation of Thin Films Oxides 显示文摘 | Leinen D Fernandez A Espinos J | 1994 | Thin Solid Films1994，241，： | 1 |
| 15 | Selenium modulates oxidative stress-induced cell apoptosis in human myeloid H1-60 cells through regulation of calcium release and caspase-3 and -9 activities显示文摘 | Uguz AC Naziroglu M Espino J | 2009 | J Membrane Biol2009，232，13： | 1 |
| 16 | Preparation of transparent and conductive Al-doped Zn O thin films by ECR plasma enhanced CVD显示文摘 | Martin A Espinos J P Justo A | 2002 | Surf Coat Technol2002，，1： | 1 |
| 17 | Analyzing comprtition between the high speed tran and alternative modes-The case of the Madrid-Zaragoza-Barcelona Corridor显示文摘 | Roman C Espino R Martín J C | 2010 | Journal of Choice Modelling2010，3，1： | 1 |
| 18 | Molecular cloning of a member of the Fasciola hepatica saposin-like protein family显示文摘 | Espino AM Hillyer GV | 2003 | J Parasitol2003，89，3： | 1 |
| 19 | Entropy analysis of the EEG background activity in Alzheimer's disease patients显示文摘 | Abasolo D I-Iornero R Espino P | 2006 | Physiol Meas2006，27，3： | 1 |
| 20 | A novel Fasciola hepatica saposinlike recombinant protein with immunoprophylactic potential显示文摘 | Espino AM Hillyer GV | 2004 | J Parasitol2004，90，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员