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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Intracellular localization of hyaluronan in proliferating cells显示文摘 | Evanko S P Wight T N | 1999 | J Histochem Cytochem1999，47，10： | 2 |
| 3 | Influnce of structural features on sorption of NOM-analogue organic acids to goethite 显示文摘 | Evanko C R Dzombak D A 1998 | 1998 | Environ Sci Technol1998，32，： | 1 |
| 4 | Hyaluronan-dependent pericellular matrix显示文摘 | EVANKO S P TAMMi M I TAMMI R H | 2007 | Adv Drug Deliv Rev2007，59，： | 1 |
| 5 | Platelet-derived Growth Factor Stimulates the Formation of Versican-hyaluronan Aggregates and Pericellular Matrix Expansion in Arterial Smooth Muscle Cells显示文摘 | Evanko S P Johnson P Y Braun K R | 2001 | Arch Biochem Biophys2001，394，1： | 1 |
| 6 | Influence of structural features on sorption of NOM-analogue organic acids to goethite 显示文摘 | Evanko C R Dzombak D A | 1998 | Environment Science Technology1998，32，： | 1 |
| 7 | Surface complexation modeling of organic acid sorption to goethite 显示文摘 | Evanko C R Dzombak D A | 1999 | Journal of Colloid and Interface Science1999，214，： | 1 |
| 8 | Hyaluronan-dependent pericellular matrix 显示文摘 | Evanko SP Tammi MI Tammi RH | 2007 | Adv Drug Deliv Rev2007，9，13： | 1 |
| 9 | Interaction with Gβγ is required for membrane targeting and palmitoylation of Ga(s)and Ga(q)显示文摘 | Evanko D S Thiyagarajan M M Wedegaertner P B | 2000 | J Biol Chem2000，275，： | 1 |
| 10 | Intracellular localization of hyaluronan in proliferating cells显示文摘 | Evanko SP Wight TN | 1999 | J Histochem Cytochem1999，47，10： | 1 |
| 11 | Platelet-derived growth factor stimulates the formation of versican-hyaluronan aggregates and pericellular matrix expansion in arterial smooth muscle cells显示文摘 | Evanko SP Johnson PY Braun KR | 2001 | Arch Biochem Biophys2001，394，1： | 1 |
| 12 | Mechanical loading and TGF-beta regulate proteoglycan synthesis in tendon 显示文摘 | Robbins JR Evanko SP Vogel KG | 1997 | Arch Biochem Biophys1997，342，2： | 1 |
| 13 | Formation of hyaluronan-and versican-rich pericellular matrix is required for proliferation and migration of vascular smooth muscle cells 显示文摘 | Evanko SP Angello JC Wight TN | 1999 | Arterioscler Thromb Vasc Boil1999，19，： | 1 |
| 14 | Influence of aqueous solution chemistry on the surface charge,viscosity and stability of concentrated alumina dispersions in water显示文摘 | Evanko C R Delisio R F Dzombak D A | 1997 | Colloids Surf1997，125，23： | 1 |
| 15 | Hyaluronan--depend- ent perieellular matrix 显示文摘 | Evanko SP Tammi MI Tammi RH | 2007 | Adv Drug Deliv Rev2007，59，13： | 1 |
| 16 | Formation of hyaluronan and versican-rich pericellular matrix is required for proliferation and migration of vascular smooth muscle cells显示文摘 | Evanko SP Angello JC Wight TN | 1999 | Arterioseter Thromb Vasc Biol1999，19，4： | 1 |
| 17 | Defining pathways of loss and secretion of chemical messengers from astrocytes显示文摘 | Evanko DS Zhang Q Zorec R | 2004 | Gila2004，47，： | 1 |
| 18 | Effects of intraoral splint wear on proteoglycans in the temporomandibular joint disc显示文摘 | Evanko S Alonzo T | 2000 | Arch Biochem Biophys2000，379，1： | 1 |
| 19 | Influence of structural features on sorption of NOM-analogue organic acids to goethite显示文摘 | Evanko C R Dzombak D A 1998 | 1998 | Environ Sci Technol1998，32，： | 1 |
| 20 | Surface complexation modeling of organic acid sorption to goethite 显示文摘 | EVANKO C R DZOMBAK D A | 1999 | Journal of Colloid and Interface Science1999，214，： | 1 |
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