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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | How the Bcl-2 family of proteins interact to regulate apoptosis显示文摘到 apoptosis 的房间的承诺主要被在 Bcl-2 蛋白质家庭的成员之间的蛋白质蛋白质相互作用管理。它的三个亚科有不同角色:BH3 仅仅,蛋白质经由他们的 BH3 领域由绑定触发 apoptosis 到支持幸存的亲戚,当 pro-apoptotic Bax 和 Bak 有一个必要下游的角色包含 organellar 膜和 caspase 激活的正式就职的混乱时。BH3 仅仅,蛋白质充当损坏传感器,由压力信号保持惰性直到他们的激活。一旦激活,他们被认为杂乱地绑在支持幸存的蛋白质目标,但是意外选择最近从他们的相互作用的分析出现了。BH3 仅仅,蛋白质也绑在 Bax 和 Bak 的一些。Bax 和 Bak 是否被这些 BH3 仅仅直接激活蛋白质,或间接地作为后果 BH3 仅仅蛋白质抵销他们的支持幸存的目标是强烈争论的题目。不管这,在家庭成员之间的相互作用的详细理解,经常选择,为设计反癌症药指向 Bcl-2 家庭有著名含意。 | Mark F van Delft David CS Huang | 2006 | Cell Research2006，16，2： | 38 |
| 3 | HCV genotypes in hepatitis C patients and their clinical significances显示文摘 | Huang F Zhao GZ Li Y | 1999 | World Journal of Gastroenterology1999，5，6： | 23 |
| 4 | Study on the expression of matrix metalloproteinase-2 mRNA in human gastric cancer显示文摘 | Ji F Wang WL Yang ZL Li YM Huang HD Chen WD | 1999 | World Journal of Gastroenterology1999，5，5： | 19 |
| 5 | Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3显示文摘AIM: To investigate the inhibitory role and the underlying mechanisms of sorafenib on signal transducer and activator of transcription 3 (STAT3) activity in hepatocellular carcinoma (HCC).METHODS: Human and rat HCC cell lines were treated with sorafenib. Proliferation and STAT3 dephosphorylation were assessed. Potential molecular mechanisms of STAT3 pathway inhibition by sorafenib were evaluated. In vivo antitumor action and STAT3 inhibition were investigated in an immunocompetent orthotopic rat HCC model.RESULTS: Sorafenib decreased STAT3 phosphorylationat the tyrosine and serine residues (Y705 and S727), but did not affect Janus kinase 2 (JAK2) and phosphatase shatterproof 2 (SHP2), which is associated with growth inhibition in HCC cells. Dephosphorylation of S727 was associated with attenuated extracellular signal-regulated kinase (ERK) phosphorylation, similar to the effects of a mitogen-activated protein kinase (MEK) inhibitor U0126, suggesting that sorafenib induced S727 dephosphorylation by inhibiting MEK/ERK signaling. Meanwhile, sorafenib could also inhibit Akt phosphorylation, and both the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and Akt knockdown resulted in Y705 dephosphorylation, indicating that Y705 dephosphorylation by sorafenib was mediated by inhibiting the PI3K/Akt pathway. Finally, in the rat HCC model, sorafenib signifi cantly inhibited STAT3 activity, reducing tumor growth and metastasis.CONCLUSION: Sorafenib inhibits growth and metastasis of HCC in part by blocking the MEK/ERK/STAT3 and PI3K/Akt/STAT3 signaling pathways, but independent of JAK2 and SHP2 activation. | Fang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian ZhouFang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian Zhou, Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Shanghai 200032, China Author contributions: Gu FM, Li QL and Gao Q contributed equally to this work Gu FM and Li QL performed the experi- ments and interpretation of the data and statistical analysis Zhou J and Gao Q contributed to the conception and design of the study Gu FM, Gao Q, Li QL and Zhou J wrote the manuscript Jiang JH, Huang XY, Pan JF and Fan J made substantial contri- bution to the design and conception of the study and interpreta- tion of data all authors read and approved the f inal manuscript. | 2011 | World Journal of Gastroenterology2011，17，34： | 18 |
| 6 | 恶性弥漫型腱鞘滑膜巨细胞肿瘤显示文摘 | Li C F Wang J W Huang W W 黄文斌(摘译) | 2008 | 临床与实验病理学杂志2008，24，4： | 12 |
| 7 | Gastroesophageal reflux: the features in elderlypatients显示文摘AIM To compare the features ofgastroesophageal reflux disease between elderlyand younger patients.METHODS Twenty-four hour pH-monitoring andendoscopy were P6rformed for the 66 elderlypatients with typical gastroesophageaI refluxsymptoms, and the results were compared with112 symptomatic younger patients.RESULTS The results of 24-h pH-monitoringand endoscopy showed that the elderly patientshad pathological reflux and reflux esophagitismore frequently than the younger patients.P6rcentage time with pH< 4 in elderly patientswith reflux esophagitis was 32.5% in 24 hours,as compared with 12.9% in the younger patientswith reflux esophagitis (P < 0 .05 ). The elderlypatients with reflux esophagitis have longerP6riOds of acid reflux in both upright and Supinepositions than the younger patients. Endoscopyshowed that 20 .8% of elderIy patients had grade Ⅲ / Ⅳ esophagitis, whereas only 3.4% ofyounger patients had grade Ⅲ/ Ⅳ esophagitis(P < 0.002 ). Percentages of grades Ⅰ /Ⅱesophagitis in the two groups were 12.5% and26. 5%, respectiveIy (P< 0. 002 ).CONCLUSION Elderly patients, as comparedwith younger patients, have more severegastroesophageal reflux and esophageal lesions.The incompetence of lower esophageal sphincter and the presence of hiataI hernia may beimportant factors leading to the difference in incidence and severity of reflux esophagitisbetween elderly and younger patients. | Huang X Zhu HM Deng CZ Porro GB Sangaletti O Pace F | 1999 | World Journal of Gastroenterology1999，5，5： | 12 |
| 8 | Handheld high-throughput plasmonic biosensor using computational on-chip imaging显示文摘We demonstrate a handheld on-chip biosensing technology that employs plasmonic microarrays coupled with a lens-free computational imaging system towards multiplexed and high-throughput screening of biomolecular interactions for point-of-care applications and resource-limited settings.This lightweight and field-portable biosensing device,weighing 60 g and 7.5 cm tall,utilizes a compact optoelectronic sensor array to record the diffraction patterns of plasmonic nanostructures under uniform illumination by a single-light emitting diode tuned to the plasmonic mode of the nanoapertures.Employing a sensitive plasmonic array design that is combined with lens-free computational imaging,we demonstrate label-free and quantitative detection of biomolecules with a protein layer thickness down to 3 nm.Integrating large-scale plasmonic microarrays,our on-chip imaging platform enables simultaneous detection of protein mono-and bilayers on the same platform over a wide range of biomolecule concentrations.In this handheld device,we also employ an iterative phase retrieval-based image reconstruction method,which offers the ability to digitally image a highly multiplexed array of sensors on the same plasmonic chip,making this approach especially suitable for high-throughput diagnostic applications in field settings. | Arif E Cetin Ahmet F Coskun Betty C Galarreta Min Huang David Herman Aydogan Ozcan Hatice Altug | 2014 | Light(Science & Applications)2014，3，1： | 6 |
| 9 | Expression and release of IL-29 by mast cells and modulation of mast cell behavior by IL-29显示文摘 | He, S Zhang, H Chen, H Yang, H Huang, T Chen, Y Lin, J Wang, F Chen, X Li, TL Yang, P | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 6 |
| 10 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 11 | 基于社区的高血压筛查两年后对血压的影响:一个全国范围老年人队列的断点回归分析显示文摘该研究旨在评估中国老年人的社区高血压筛查对后续血压水平的影响。研究人员对一个全国范围老年人队列进行断点回归分析。研究背景:2011年12月和2014年两次中国中老年人群纵向健康长寿调查。参与者:3899名未确诊高血压的老年人。主要观察指标:初筛2年后的老年人血压。 | 陈嘉睿(译) 叶鹏(审校) Chen S Sudharsanan N Huang F Liu Y Geldsetzer P Barnighausen T | 2019 | 中华高血压杂志2019，27，11： | 5 |
| 12 | Comparison of HER-2/neu,ER and PCNA expression in premenopausal and postmenopausal patients with breast carcinoma显示文摘 | Zheng W Zheng J Ma L Meng F Huang L Ma D | 2005 | 第二军医大学学报2005，26，8： | 4 |
| 13 | Current status of research and application in vascular stents显示文摘Cardiovascular diseases have been the leading cause of death in modern society.Using vascular stents to treat these coronary and peripheral artery diseases has been one of the most effective and rapidly adopted medical interventions.During the twenty-five years’development of vascular stents,revolutionary cardiovascular stents like drug eluting stents and endothelial progenitor cells capture stents have emerged.In this review,the evolution of vascular stents is summarized,aiming to provide a glimpse into the future of vascular stents.Advanced designs,focusing on the investigations of new substrates,new platforms,new drugs and new biomolecules are currently under evaluation with promising clinical studies.The concept of'time sequence functional stent'has been raised in this paper.It presents anti-proliferative properties in the first phase after implantation and subsequently support endothelialization.It also shows long-term inertness without release of toxic ions or toxic degradation products.The success of this concept is briefly presented with a clinical study in this model stents. | QI PengKai YANG Ying MAITZ F Manfred HUANG Nan | 2013 | Chinese Science Bulletin2013，58，35： | 3 |
| 14 | Cultivation-dependent and cultivation-independent characterization of the microbial community in acid mine drainage associated with acidic Pb/ Zn mine tailings at Lechang, Guangdong, China显示文摘 | Tan GL Shu WS Hallberg KB Li F Lan CY Huang LN | 2007 | 中国生物学文摘2007，21，7： | 3 |
| 15 | “东风何时至,已绿湖上山”--远程卒中在中国显示文摘1背景介绍中国国家卒中登记数据显示,2007-2008年,中国急性缺血性卒中静脉溶栓率仅为1.6%。2011年中国的急性缺血性卒中患者发病至用药时间平均为180 min,入院至治疗时间平均为116 min,这些质量评估数据远逊于发达国家。目前,"互联网+医疗"在中国也受到了极大关注,中国卒中学会顺应时代成立了移动医疗分会,推动远程卒中在中国的发展。 | zhao g huang h yang f 张清华 | 2018 | 中国卒中杂志2018，13，2： | 2 |
| 16 | 钒微合金化在汽车用先进高强钢中的应用显示文摘回顾了过去10年发表的在扁平材中使用钒微合金化技术所取得的一些进步,并讨论了该技术在汽车用先进高强钢(AHSS)中的应用;探讨了该技术对系列钢种可能带来的益处,这些钢种包括双相(DP)钢、全贝氏体钢、相变诱发塑性(TRIP)钢、孪生诱发塑性(TWIP)钢,并提供了示例。此外,还提出了值得AHSS生产商提供支持、应当持续研究的领域。 | Scott C P Milbourn D Huang M Perrard F | 2013 | 钢铁钒钛2013，34，5： | 2 |
| 17 | Modeling superheat removal during continuous casting of steel slabs显示文摘 | Huang X Thomas B G Najjar F M | 1992 | Metall Trans B1992，23，： | 2 |
| 18 | Variable gain parameter estimation algorithms for fast tracking and smooth steady state 显示文摘 | Bai Er W Huang Y F | 2000 | Automatic2000，36，： | 2 |
| 19 | Evaluating the inter-lobe clearance of twin-screw compressor by the iso-clearance contour diagram(ICCD) 显示文摘 | Fong Z H Huang F C Fang H S | 2001 | Mechanism and Machine Theory2001，36，6： | 2 |
| 20 | Correlation of fully developed heat transfer and pressure drop in a symmetrically grooved channel显示文摘 | Wirtz R A Huang F Greiner M | 1999 | ASME Journal of Heat Transfer1999，121，1： | 2 |
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