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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | How to perform gastrointestinal ultrasound: anatomy and normal findings显示文摘Gastrointestinal ultrasound is a practical, safe, cheap and reproducible diagnostic tool in inflammatorybowel disease gaining global prominence amongst clinicians. Understanding the embryological processes of the intestinal tract assists in the interpretation of abnormal sonographic findings. In general terms, the examination principally comprises interrogation of the colon, mesentery and small intestine using both lowfrequency and high-frequency probes. Interpretation of findings on GIUS includes assessment of bowel wall thickness, symmetry of this thickness, evidence of transmural changes, assessment of vascularity using Doppler imaging and assessment of other specific features including lymph nodes, mesentery and luminal motility. In addition to B-mode imaging, transperineal ultrasonography, elastography and contrast-enhanced ultrasonography are useful adjuncts. This supplement expands upon these features in more depth. | Nathan S S Atkinson Robert V Bryant Yi Dong Christian Maaser Torsten Kucharzik Giovanni Maconi Anil K Asthana Michael Blaivas Adrian Goudie Odd Helge Gilja Dieter Nuernberg Dagmar Schreiber-Dietrich Christoph F Dietrich | 2017 | World Journal of Gastroenterology2017，23，38： | 5 |
| 3 | Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial显示文摘 | Eric Lawitz Fred F Poordad Phillip S Pang Robert H Hyland Xiao Ding Hongmei Mo William T Symonds John G McHutchison Fernando E Membreno | 2013 | The Lancet2013，，： | 5 |
| 4 | Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features显示文摘 | Walter F Stewart Joshua N Liberman Robert S Sandler Michael S Woods Annette Stemhagen Elsbeth Chee Richard B Lipton Christina E Farup | 1999 | The American Journal of Gastroenterology1999，，12： | 2 |
| 5 | Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains显示文摘 | George P Robert F Gerry S | 1987 | PNAS1987，84，： | 1 |
| 6 | Application of Burkholderia cepacia and Trichoderma virens,alone and in combinations,a-gainst Meloidogyne incognita on bell pepper显示文摘 | MEYER S L F ROBERTS D P CHITWOOD D J | 2001 | Nematropica2001，，： | 1 |
| 7 | Site-specific reversible scission of hydrogen bonds in polymers:An investigation of polyamides and their lewis acidbase complexes by infrared Spectroscopy显示文摘 | Roberts M F Jennkhe S A | | 0，，： | 1 |
| 8 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 9 | Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period, the epidemiologic data on the insulin resistance syndrome prospective study显示文摘 | Frederic F Roberte A Afshan S | 2004 | Diabetes2004，53，： | 1 |
| 10 | Low-level expression of HER2 and CK19 in normal peripheral blood mononuclear cells: relevance for detection of circulating tumor cells显示文摘 | You F Roberts L A Kang S P | 2008 | J Hematol Oncol2008，28，1： | 1 |
| 11 | Techniques for the study and development of microbial fuel cells: an electrochemical perspective 显示文摘 | Zhao F Robert C T S John R V | 2009 | Chem Soc Rev2009，38，： | 1 |
| 12 | Spatially Variant Contrast Enhancement Using Local Ranger Modification 显示文摘 | James D F Robert A S | 1983 | SPIE1983，2213，： | 1 |
| 13 | New high-speed scanning technique for Computed Radiography显示文摘 | Ralph S Robert F Peter K | 2002 | SPIE2002，4682，： | 1 |
| 14 | An unusually large multifunctional polypeptide in the erythromycin- producing polyketide synthase of Saecharopolyspora erythraea显示文摘 | Cortes J Haydock S F Roberts G A | 1990 | Nature1990，348，： | 1 |
| 15 | Zinc and carbon co-limitation of marine phytoplankton显示文摘 | Morel F M M Reinfelder J R Roberts S B Chamberlain C P Lee J G Yee D | 1994 | Nature1994，369，6483： | 1 |
| 16 | Interlocking Directorates : A Strategy for Reducing Environmental Un - certainty显示文摘 | F David Schoorman Max H Bazerman Robert S Atkin | 1981 | A- cademy of Management1981，6，2： | 1 |
| 17 | Object - based visual attention for computer vision 显示文摘 | YAORU S ROBERT F | 2003 | Artificial Intelligence2003，，146： | 1 |
| 18 | CTLA-4 and PD-1/PD-L1 blockade : new immunotherapentic modalities with durable clini- cal benefit in melanoma patients 显示文摘 | Ott P A Hodi F S Robert C | 2013 | Clinical Cancer Re- search2013，19，19： | 1 |
| 19 | An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea 显示文摘 | Cortes J Haydock S F Roberts G A | 1990 | Nature1990，348，6297： | 1 |
| 20 | The role of elevation and soil chemistry in the distribution and ion accumulation of floral morphs of Streptanthus polygaloides Gray (Brassicaceae), a Californian nickel?hyperaccumulator 显示文摘 | Nathaniel P Michael F Robert S B | 2014 | Plant ecology & diversity2014，7，42： | 1 |
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