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| 1 | Detection of dietary plant-based small RNAs in animals显示文摘 | Jian Yang Lisa M Farmer Abia AA Agyekum Kendal D Hirschi | 2015 | Cell Research2015，25，4： | 9 |
| 2 | Assessment of the cardiovascular and gastrointestinal autonomic complications of diabetes显示文摘The global prevalence of diabetes mellitus is increasing; arguably as a consequence of changes in diet, lifestyle and the trend towards urbanization. Unsurprisingly, the incidence of both micro and macrovascular complications of diabetes mirrors this increasing prevalence. Amongst the complications with the highest symptom burden, yet frequently under-diagnosed and sub-optimally treated, is diabetic autonomic neuropathy, itself potentially resulting in cardiovascular autonomic neuropathy and gastrointestinal(GI) tract dysmotility. The aims of this review are fourfold. Firstly to provide an overview of the pathophysiological processes that cause diabetic autonomic neuropathy. Secondly, to discuss both the established and emerging cardiometric methods for evaluating autonomic nervous system function in vivo. Thirdly, to examine the tools for assessing pan-GI and segmental motility and finally, we will provide the reader with a summary of putative non-invasive biomarkers that provide a pathophysiological link between lowgrade neuro inflammation and diabetes, which may allow earlier diagnosis and intervention, which in future may improve patient outcomes. | Christina Brock Birgitte Brock Anne Grave Pedersen Asbjorn Mohr Drewes Niels Jessen Adam D Farmer | 2016 | World Journal of Diabetes2016，7，16： | 5 |
| 3 | High efficiency, high power 808nm laser array and stacked arrays optimized for elevated temperature operation显示文摘Operation of 808-nm laser diode pumping at elevated temperature is crucial to many applications. Reliable operation at high power is limited by high thermal load and low catastrophic optical mirror damage (COMD) threshold at elevated temperature range. We demonstrated high efficiency and high power operation at elevated temperature with high COMD power. These results were achieved through device design optimization such as growth conditions, doping profile, and materials composition of the quantum-well and other layers. Electrical-to-optical efficiency as high as 62% was obtained through lowered threshold current, lowered series resistance and increased slope efficiency. The performance of single broad-area laser diodes scales to that of high power single bars on water-cooled copper micro-channel heatsinks or conductively-cooled CS heatsinks. No reduction in bar performance or significant spectral broadening is seen when these micro-channel coolers are assembled into 6-bar and 18-bar CW stacks for the highest power levels. | Crump P A Crum T R DeVito M Farmer J Grimshaw M Huang Z Igl S A Macomber S Thiagarajan P Wise D | 2004 | 光机电信息2004，21，6： | 4 |
| 4 | Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation. | Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes | 2016 | World Journal of Diabetes2016，7，2： | 4 |
| 5 | A CMOS based analog standard cell product family 显示文摘 | Smith L D Farmer H R Kunesh M | 1989 | IEEE Journal of Solid-State Circuits1989，24，4： | 2 |
| 6 | Immunobead-PCR:A technique for the detection of circulating tumor cells using immunomagnetic beads and the polymerase chain reaction显示文摘 | Hardingham JE Kotasek D Farmer B | 1993 | Cancer Res1993，53，： | 2 |
| 7 | Geometry from a time series显示文摘 | Packard N H Crutchield J P Farmer J D | | 0，，09： | 2 |
| 8 | Calculation of the effects of protonation on rigid-rod polymers显示文摘 | Farmer B L Dudis D S Adams W W | 1994 | Polymer1994，35，17： | 1 |
| 9 | Predicting chaotic time series 显示文摘 | FARMER J D SIDOROWICH J J | 1987 | Phys Rev Lett1987，59，： | 1 |
| 10 | Synthesis of bulky β-lactams for inhibition of cell surface β-lactamase activity显示文摘 | Karunaaratne D N Farmer R Hancock E W | 1993 | Bioconjugate Chem1993，4，： | 1 |
| 11 | Geometry from a time series显示文摘 | PACKARD N H CRUTCHFIELD J P FARMER J D | 1980 | Physics Review Letters1980，，： | 1 |
| 12 | Morphometric relationships of commercially important species of penaeid shrimp from the Arabian Gulf显示文摘 | FARMER A S D | 1986 | Kuwait Bull Mar Sci1986，7，： | 1 |
| 13 | The economy needs agent-based modelling 显示文摘 | Farmer J D Foley D | 2009 | Nature2009，460，7256： | 1 |
| 14 | Real-time aerosol mass spectrometry with millisecond resolution 显示文摘 | Kimmel J R Farmer D K Cubison M J | 2011 | Int J Mass Spectrom2011，303，1： | 1 |
| 15 | 查看详情显示文摘 | N H Packard J P Crutchfield J D Farmer | | 0，，： | 1 |
| 16 | Framework for the incorporation of demand-side in a competitive electricity market显示文摘 | Strbac G Farmer E D Cory B J | 1996 | IEE Proceedings-Generation Transmission and Distribution1996，143，3： | 1 |
| 17 | Predicting Chaotic Time Series显示文摘 | Farmer J D Sidorowich J J | 1987 | Physi- cal Review Letters1987，，59： | 1 |
| 18 | Optimal shadowing and noise reduction显示文摘 | Farmer J D Sidorowich J J | 1991 | Physica D1991，47，3： | 1 |
| 19 | Revenue reconciled optimal pricing of transmission services 显示文摘 | Farmer E D Cory B J | 1996 | IEEE Transactions on Power Systems1996，11，14： | 1 |
| 20 | Geometry from a time series显示文摘 | PACKARD N H CRUTCHFIELD J P FARMER J D | 1989 | Physical Reviem Letter1989，45，9： | 1 |
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