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| 1 | Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro显示文摘AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells.METHODS:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:< 3 kDa,3-30 kDa,and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear phagocytes.The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow cytometry.RESULTS:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes.The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite fraction.Changes were also seen for the dendritic cell maturation markers CD80 and CD86.On CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright cells.The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation.The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells.CONCLUSION:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making. | Kathleen F Benson Kimberlee A Redman Steve G Carter David Keller Sean Farmer John R Endres Gitte S Jensen | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 2 | High efficiency, high power 808nm laser array and stacked arrays optimized for elevated temperature operation显示文摘Operation of 808-nm laser diode pumping at elevated temperature is crucial to many applications. Reliable operation at high power is limited by high thermal load and low catastrophic optical mirror damage (COMD) threshold at elevated temperature range. We demonstrated high efficiency and high power operation at elevated temperature with high COMD power. These results were achieved through device design optimization such as growth conditions, doping profile, and materials composition of the quantum-well and other layers. Electrical-to-optical efficiency as high as 62% was obtained through lowered threshold current, lowered series resistance and increased slope efficiency. The performance of single broad-area laser diodes scales to that of high power single bars on water-cooled copper micro-channel heatsinks or conductively-cooled CS heatsinks. No reduction in bar performance or significant spectral broadening is seen when these micro-channel coolers are assembled into 6-bar and 18-bar CW stacks for the highest power levels. | Crump P A Crum T R DeVito M Farmer J Grimshaw M Huang Z Igl S A Macomber S Thiagarajan P Wise D | 2004 | 光机电信息2004，21，6： | 4 |
| 3 | Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation. | Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes | 2016 | World Journal of Diabetes2016，7，2： | 4 |
| 4 | Calculation of the effects of protonation on rigid-rod polymers显示文摘 | Farmer B L Dudis D S Adams W W | 1994 | Polymer1994，35，17： | 1 |
| 5 | Isolation and properties of teleostean growth hormone显示文摘 | Farmer S W H Papoff T A Bensley | 1976 | Gen Comp Endocrinol1976，30，： | 1 |
| 6 | Morphometric relationships of commercially important species of penaeid shrimp from the Arabian Gulf显示文摘 | FARMER A S D | 1986 | Kuwait Bull Mar Sci1986，7，： | 1 |
| 7 | A Com- bined Uninterruptible Power Supply and Dynamic Voltage Compensa- tor Using a Flywheel Energy Storage System 显示文摘 | Robert S Weissbach George G Karady Richard G Farmer | 2001 | Transaction on Power Delivery2001，16，2： | 1 |
| 8 | 3I) seismic discontinuity fir faults and stratigraphic tatlers: the coherence cube 显示文摘 | Bahorich M Farmer S | 1995 | The Leading Edge1995，14，10： | 1 |
| 9 | 3-D seismic at- tributes using a semblance-based coherency algorithm显示文摘 | Marfurt K J Kirlin R L Farmer S L | 1998 | Geophysics1998，63，4： | 1 |
| 10 | Treatment of extensively drug-resistant tuberculosis in Tomsk,Russia:a retrospective cohort study显示文摘 | Keshavjee S Gelmanova IY Farmer PE | | 0，，9647： | 1 |
| 11 | Dynamic voltage compensation on distribution feeders using flywheel energy storage显示文摘 | Weissbach R S Karady G G Farmer R G | 1999 | IEEE Transactions on Power Delivery1999，14，2： | 1 |
| 12 | Employee creativity in taiwan : an application of role identity theory 显示文摘 | Farmer S M Pamela T Kate K - M | 2003 | The Academy of Management Journal2003，46，5： | 1 |
| 13 | A bilateral gynandromorphy of Nephrops norvegicus (Decapoda, Nephropidae)显示文摘 | Farmer A S | 1972 | Mar Biol1972，15，： | 1 |
| 14 | 3-D seismic coherency for faults and stratigraphic features显示文摘 | Bahorich M S Farmer S L | 1995 | The Leading Edge1995，60，3： | 1 |
| 15 | 3 D seismic at- tributes using a semblance - based coherency algorithm 显示文摘 | Marfurt K J Kirlin R L Farmer S L | 1998 | Geophysics1998，63，4： | 1 |
| 16 | An examination of leadership and employee creativity : The relevance of traits and relationships 显示文摘 | Tiemey P Farmer S M Graen G B | 1999 | Personnel Psychology1999，52，3： | 1 |
| 17 | An Examination of Leadership and Employee Creativity:The Relevance of Traits and Relationships显示文摘 | Tierney P Farmer S M Graen G B | | 0，，03： | 1 |
| 18 | 3-D seismic attributes using a semblance-based coherency algorithm 显示文摘 | Kirlin R L Farmer S L | 1998 | Geophysics1998，63，4： | 1 |
| 19 | Creative self - efficacy: its potential antecedents and relationship to creative performance显示文摘 | Pamela T Farmer S M | 2002 | The Academy of Management Journal2002，45，6： | 1 |
| 20 | Impact of selective posterior rhizotomy on fine motor skills:long-term results using a validated evaluative measure显示文摘 | Mittal S Farmer JP Al-Atassi B | 2002 | Pediatr Neurosurg2002，36，3： | 1 |
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