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| 1 | Relation of atrophic gastritis with Helicobacter pylori-CagA^+ and interleukin-1 gene polymorphisms显示文摘AIM: To determine the association of Helicobacter pylori (H pylori) CagA+ infection and pro-inflammatory poly-morphisms of the genes interleukin (IL)-1RN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of gastric cancer. METHODS: Seven biopsy specimens, a fasting blood sample and a questionnaire concerning nutritional and sociodemographic factors were obtained from 501 con-secutive patients who had undergone endoscopy for dyspeptic symptoms. A histopathological diagnosis was made. Pepsinogen concentrations were analyzed by enzyme linked immunosorbent assay (ELISA). Infection with H pylori CagA+ was determined by serology and polymerase chain reaction (PCR). IL-1B and IL-1RN polymorphisms genotyping was performed by PCR-restriction fragment length polymorphism (PCR-RFLP)and PCR respectively. RESULTS: In this dyspeptic population, 86% were H pylori positive and of these, 67.8% were positive for CagA. Atrophic antral gastritis (AAG) was associated with CagA+ status [odd ratio (OR) = 4.1; P < 0.000] and fruit consumption (OR = 0.3; P < 0.00). Atrophic body gastritis (ABG) was associated with pepsinogen PGI/PGII < 3.4 (OR = 4.9; P < 0.04) and alcohol consumption (OR = 7.3; P < 0.02). Duodenal ulcer was associated with CagA+ (OR = 2.9; P < 0.04) and smoking (OR = 2.4; P < 0.04). PGI < 60 μg/L as well as PGI/PGII < 3.4 were associated with CagA+. CONCLUSION: In a dyspeptic population in Costa Rica, H pylori CagA+ is not associated with ABG, but it is a risk factor for AAG. The pro-inflammatory cytokine poly-morphisms IL-1B + 3945 and IL-1RN are not associated with the atrophic lesions of this dyspeptic population. | Rafaela Sierra Clas Une Vanessa Ramírez Warner Alpízar-Alpízar María I González José A Ramírez Antoine de Mascarel Patricia Cuenca Guillermo Pérez-Pérez Francis Mégraud | 2008 | World Journal of Gastroenterology2008，14，42： | 2 |
| 2 | A new language for neuronal dynamics 显示文摘 | So P Francis J T Netoff T I | 1998 | Biophys Journal1998，74，6： | 2 |
| 3 | Alkali Reductive Roasting of Ilmenite Ore显示文摘 | El-Tawil S Z Mosri I M Yehia A Francis A A | 1996 | Canadian Metallurgical Quarterly1996，35，1： | 1 |
| 4 | The Volatile Composition of Chardonnay Juices a Study by Flavor precursor Analysis显示文摘 | Sefton M A Francis I L Williams P J | 1993 | American Journal of Enology and Viticulture1993，44，4： | 1 |
| 5 | Can firms learn by observing? Evidence from cross-border M&As 显示文摘 | Francis B B Hasan I Sun X Waisman M | 2014 | Journal of Corporate Finance2014，25，： | 1 |
| 6 | Effects of co- fermentation with Candida stellata and Saccharomyces cerevisiae on the aroma and composition of Chardormay wine 显示文摘 | Soden A Francis I L Oakey H | 2000 | Australian Journal of Grape and Wine Research2000，6，1： | 1 |
| 7 | Adrenal radiology: dis tinguishing benign from malignant adrenal masses显示文摘 | Dunnick NR Korobkin M Francis I | 1996 | AJR1996，167，： | 1 |
| 8 | Adrenal radiology: distin guishing benign from malignant adrenal masses显示文摘 | Dunnick NR Korobkin M Francis I | 1996 | Am J Roent genol1996，167，10： | 1 |
| 9 | Her-2 neu (Cerb-B2) expression in fine needle aspiration samples of breast carcinoma: a pilot study comparing FISH, CISH and immunocytochemistry 显示文摘 | Kapila K A1-Awadhi S Francis I | 2011 | J Cytol2011，28，2： | 1 |
| 10 | Political connections and the process of going public:evidence from China显示文摘 | FRANCIS B B HASAN I SUN X | 2009 | Journal of International Money and Finance2009，，28： | 1 |
| 11 | Action of intraeellular IL-1Ra (Type 1 ) is independent of the IL-1 intracellular signalling pathway显示文摘 | Evans I Dower SK Francis SE | 2006 | Cytokine2006，33，5： | 1 |
| 12 | Preoperative staging of non-small-cell carcinoma of the lung:imaging methods显示文摘 | Quint L E Francis I R Wahl R L | 1995 | AJR Am J Roentgenol1995，164，6： | 1 |
| 13 | Cloning and characterization of the cDNA for lycopene β-cyclase from tomato reveals decrease in its expression during fruit ripening显示文摘 | Pecker I Gabbay R Francis X | 1996 | Plant Mol Biol1996，30，： | 1 |
| 14 | Array com parative genomic hybridization reveals loss of SOCS6 is associated with poor prognosis in primary lung squamous cell carcinoma显示文摘 | Sriram KB I arsen J E Savarimuthu Francis SM | 2012 | PLoS One2012，7，30： | 1 |
| 15 | Sensory descriptive analysis of aroma of hydrolysed precursor fractions from semillon, chardonnay and sauvignon blanc grape juices显示文摘 | FRANCIS I L SEFTON M A WILLIANS P J | 1992 | Journal of the Science of Food and Agriculture1992，59，4： | 1 |
| 16 | Loss of ge- netic diversity due to fishing pressure 显示文摘 | Smith P J Francis R I C C McVeagh M | 1991 | Fish Res1991，10，34： | 1 |
| 17 | New numerical procedure for the prediction of temperature development in early age concrete structures显示文摘 | Anka Ilc Goran Turk Franci Kav?i? Gregor Trtnik | 2009 | Automation in Construction2009，，6： | 1 |
| 18 | Comparisons of dynamic infusion and delayed computed tomography, intraoperative ultrasound, and palpation in the diagnosis of liver metastases显示文摘 | Knol J A Marn C S Francis I R | 1993 | Am JSurg1993，165，1： | 1 |
| 19 | TNIPI, a retinoic acid receptor corepressor and A20-binding inhibitor of NF-KB, distributes to both nu?clear and cytoplasmic locations显示文摘 | Gurevich I Zhang C Francis N | 2011 | J Histochem Cytochem2011，59，12： | 1 |
| 20 | Action of intracellular IL-1Ra (Type 1) is independent of the IL-I intracellular signalling pathway显示文摘 | Dower SK Francis SE | 2006 | Cytokine2006，33，5： | 1 |
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