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| 1 | Effect of nutritional counselling on hepatic,muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease显示文摘AIM: To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL). METHODS: Whole body MRI and 1H MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease (NAFLD). RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4% (-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT) depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and intra-abdominal-AT (-11.4%). Intramyocellular lipids (IMCL) were significantly reduced in the tibialis muscle (-28.2%). Decreases in both IHCL (-39.9%) and soleus IMCL (-12.2%) content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION: This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LFTs. | E Louise Thomas Audrey E Brynes Gavin Hamilton Nayna Patel Adam Spong Robert D Goldin Gary Frost Jimmy D Bell Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，36： | 13 |
| 2 | An in vivo 13C magnetic resonance spectroscopic study of the relationship be- tween diet and adipose tissue composition 显示文摘 | THOMAS E FROST G BARNARD M | 1996 | Lipids1996，31，2： | 1 |
| 3 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 4 | Subglottic secretion drainage for preventing ventilator associated pneumonia:a meta-analysis显示文摘 | Frost SA Azeem A Alexandrou E | 2013 | Aust Crit Care2013，26，4： | 1 |
| 5 | Strontium isotope geochemistry of groundwater in the central part of the Dakota (Great Plains) aquifer, USA显示文摘 | GOSSELINA D C HARVEYA F E FROST C | 2004 | Applied Geochemistry2004，19，： | 1 |
| 6 | Mechano-chemical treatment of kaolinite显示文摘 | Frost R L Mako E Kristof J Horvath E Theo-kloprogge J | 2001 | Journal of Colloid and Interface Science2001，239，： | 1 |
| 7 | Effect of water on the formamide-intercalation of kaolinite显示文摘 | FROST R L KRISTOF J HORVATH E | 2000 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2000，56，9： | 1 |
| 8 | Comparison of antimicrobial resistance of Campylobacter jejuni isolated from humans, chickens raw milk, and environmental water in Quebec 显示文摘 | Levesque S Frost E Michaud S | 2007 | J Food Prot2007，70，3： | 1 |
| 9 | A study of structural memory effects in synthetic hydrotalcites using environmental SEM 显示文摘 | K L Erickson T E Bostrom R L Frost | 2005 | Materials Letters2005，59，23： | 1 |
| 10 | Initiation of oligodendrocyte progenitor cell migration by a PDGF-A ac- tivated extracellular regulated kinase (ERK) signaling path- way显示文摘 | FROST E E ZHOU Z C KRASNESKY K | 2009 | Neurochem Res2009，34，1： | 1 |
| 11 | Effect of water on the formamide-intercalation of kaolinite显示文摘 | KRISTOF J HORVATH E | 2000 | Spectrochimica Acta Part A2000，56，： | 1 |
| 12 | Clonal origin of bladder cancer显示文摘 | Sidransky E A Frost P von Eschenbach A | 1992 | N Engl J Med1992，326，： | 1 |
| 13 | Effect of water on the formamide-intercalation of kaolinite 显示文摘 | Frost R L Kristof J Horvath E | 2000 | Spectrochimica Acta Part A2000，56，： | 1 |
| 14 | Agronomic implications of variation in wheat development due to variety, sowing date, site and season显示文摘 | Spink J H Kirby E M Frost D L | 2000 | Plant Varieties and Seeds2000，13，2： | 1 |
| 15 | Src inhibition ameliorates polycystie kidney disease显示文摘 | Sweeney W E Jr von Vigier R O Frost P Avner E D | 2008 | J Am Soe Nephrol2008，19，： | 1 |
| 16 | Persistence of a 1930 swine influenza A(H1N1)virus in Quebec显示文摘 | BIKOUR M H FROST E H DESLADEES S | 1995 | J Gen Virol1995，76，10： | 1 |
| 17 | Acoustic Radiation from Surfaces Oscillating at Large Amplitude and Small Math Number显示文摘 | Frost P A Harper E Y | 1975 | J Acous Soc Am1975，58，： | 1 |
| 18 | Aberrant expression of G(1)/S regulators is a frequent event in sporadic pituitary adenomas显示文摘 | Simpson D J Frost S J Bicknell J E | 2001 | Carcinogenesis2001，22，8： | 1 |
| 19 | Monitoring hydraulic gradient using three-point estimator 显示文摘 | S1LLIMAN S E FROST C | 1998 | Journal of Environmental Engineering ASCE1998，124，6： | 1 |
| 20 | The simulation theatre:a means to enhanced learning in the 21^st century显示文摘 | Bryson E O Levine Frost E A | 2008 | Middle East J Anesthersiol2008，19，5： | 1 |
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