|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection显示文摘Injuries to the postnatal skeleton are naturally repaired through successive stepsinvolving specific cell types in a process collectively termed “bone regeneration”.Although complex, bone regeneration occurs through a series of well-orchestratedstages wherein endogenous bone stem cells play a central role. In most situations,bone regeneration is successful;however, there are instances when it fails andcreates non-healing injuries or fracture nonunion requiring surgical or therapeuticinterventions. Transplantation of adult or mesenchymal stem cells (MSCs) definedby the International Society for Cell and Gene Therapy (ISCT) as CD105+-CD90+CD73+CD45-CD34-CD14orCD11b-CD79αorCD19-HLA-DR- is beinginvestigated as an attractive therapy for bone regeneration throughout the world.MSCs isolated from adipose tissue, adipose-derived stem cells (ADSCs), aregaining increasing attention since this is the most abundant source of adult stemcells and the isolation process for ADSCs is straightforward. Currently, there isnot a single Food and Drug Administration (FDA) approved ADSCs product forbone regeneration. Although the safety of ADSCs is established from their usagein numerous clinical trials, the bone-forming potential of ADSCs and MSCs, ingeneral, is highly controversial. Growing evidence suggests that the ISCT definedphenotype may not represent bona fide osteoprogenitors. Transplantation of bothADSCs and the CD105- sub-population of ADSCs has been reported to induce bone regeneration. Most notably, cells expressing other markers such as CD146,AlphaV, CD200, PDPN, CD164, CXCR4, and PDGFRα have been shown torepresent osteogenic sub-population within ADSCs. Amongst other strategies toimprove the bone-forming ability of ADSCs, modulation of VEGF, TGF-β1 andBMP signaling pathways of ADSCs has shown promising results. The U.S. FDAreveals that 73% of Investigational New Drug applications for stem cell-basedproducts rely on CD105 expression as the “positive” marker for adult stem cells.A concerted effort involving the scientific community, clinicians, industries, andregulatory bodies to redefine ADSCs using powerful selection markers andstrategies to modulate signaling pathways of ADSCs will speed up thetherapeutic use of ADSCs for bone regeneration. | Quang Le Vedavathi Madhu Joseph M Hart Charles R Farber Eli R Zunder Abhijit S Dighe Quanjun Cui | 2021 | World Journal of Stem Cells2021，13，9： | 2 |
| 2 | Accounting for the value of ecosystem services显示文摘 | Howarth R B Farber S | 2002 | Ecological Economics2002，41，3： | 1 |
| 3 | Arabinogalac- tan - folic acid - drug conjugate for targeted delivery and target - ac- tivated release of anticancer drugs to folate receptor - overexpress- ing cells 显示文摘 | PINHASSI R I ASSARAF Y G FARBER S | 2010 | Biomacromolecules2010，11，1： | 1 |
| 4 | Valuing ecosystem services显示文摘 | Liu S Costanza R Farber S | 2010 | Annals of the New York Academy of Sciences2010，1185，1： | 1 |
| 5 | Coverage of the left subclavian artery during thoracic endovascular aortic repair 显示文摘 | Riesenman P J Farber M A Mendes R R | 2007 | J Vasc Surg2007，45，1： | 1 |
| 6 | Valuation and management of wetland ecosystems显示文摘 | Costanza R Farber S C Maxwell J | 1989 | Ecological Economics1989，1，33： | 1 |
| 7 | Determination of antibiotic residues in manure, soil, and surface waters显示文摘 | Christian T Schneider R J Farber H A | 2003 | Acta Hydroehim Hydrobiol2003，31，1： | 1 |
| 8 | Valuation and management of wetlands ecosystem servicees显示文摘 | Farber S C Maxewell J | 1989 | Ecological Economics1989，16，1： | 1 |
| 9 | Monitoring the Production of Aflatoxin B1 in Wheat by Measuring the Concentration of nor-1 mRNA显示文摘 | Mayer Z Farber P Geisen R | 2003 | Applied And Enviornmental Microbiology2003，3，： | 1 |
| 10 | Accounting for the value of ecosystem services 显示文摘 | Howarth R B Farber S | 2002 | Ecological Economics2002，41，3： | 1 |
| 11 | A weak calcium binding site in subtilisin BPN has a dramatic effect on protein stability 显示文摘 | R D Kidd H P Yennawar P Sears CH Wong G K Farber | 1996 | Am Chem Soc1996，118，： | 1 |
| 12 | Determination of antibi-otic residues in manure, soil, and surface waters显示文摘 | Christian T Schneider R J Farber H A | 2003 | Acta HydrochimicaEt Hydrobiologica2003，31，1： | 1 |
| 13 | The conversion of SO2 to sulfate in the atmosphere显示文摘 | Eatough D J Caka F M Farber R J | 1994 | Israel Journal of Chemistry1994，34，34： | 1 |
| 14 | The pathogenesis of irreversible cell injury in isehemia显示文摘 | FARBER J L CHIEN K R MITTNACHT S J R | 1981 | Am J Pathol1981，102，： | 1 |
| 15 | Assessment of alterna- tive approaches for bioclimatic modeling with spe- cial emphasis on the Mahalanobis distance显示文摘 | FARBER O KADMON R | 2003 | Eco- logical Modelling2003，160，12： | 1 |
| 16 | Mass spectrometric kinetic studies on several azido polymers 显示文摘 | Farber M Harris S P and Srivastava R D | 1984 | Combustion and Flame1984，55，： | 1 |
| 17 | A weak calcium binding site in subtilisin BPN-has a dramatic effect on protein stability显示文摘 | R D Kidd H P Yennawar P Sears C H Wong G K Farber | 1996 | Am Chem Soc1996，118，： | 1 |
| 18 | Accounting for the value of ecosystem services显示文摘 | Howarth R B Farber S | 2002 | Ecological Economics2002，41，3： | 1 |
| 19 | Economic and Ecological Concepts for Valuing Ecosystem Services显示文摘 | Farber S Costanza R Wilson M | 2002 | Ecological Economics2002，41，： | 1 |
| 20 | Determination of antibiotic residues in manure,soil,and surface water显示文摘 | Christian T Schneider R J Farber H A | 2003 | Acta Hydrochim Hydrobiol2003，31，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员