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| 1 | Treatment with NADPH oxidase inhibitor apocynin alleviates diabetic neuropathic pain in rats显示文摘Increased reactive oxygen species by the activation of NADPH oxidase(NOX) contributes to the development of diabetic complications.Apocynin,a NOX inhibitor,increases sciatic nerve conductance and blood flow in diabetic rats.We investigated potential protective effect of apocynin in rat diabetic neuropathy and its precise mechanism of action at molecular level.Rat models of streptozotocin-induced diabetes were treated with apocynin(30 and 100 mg/kg per day,intragastrically) for 4 weeks.Mechanical hyperalgesia and allodynia were determined weekly using analgesimeter and dynamic plantar aesthesiometer.Western blot analysis and histochemistry/immunohistochemistry were performed in the lumbar spinal cord and sciatic nerve respectively.Streptozotocin injection reduced pain threshold in analgesimeter,but not in aesthesiometer.Apocynin treatment increased pain threshold dose-dependently.Western blot analysis showed an increase in catalase and NOX-p47 phox protein expression in the spinal cord.However,protein expressions of neuronal and inducible nitric oxide synthase(n NOS,i NOS),superoxide dismutase,glutathion peroxidase,nitrotyrosine,tumor necrosis factor-α,interleukin-6,interleukin-1β,aldose reductase,cyclooxygenase-2 or MAC-1(marker for increased microgliosis) in the spinal cord remained unchanged.Western blot analysis results also demonstrated that apocynin decreased NOX-p47 phox expression at both doses and catalase expression at 100 mg/kg per day.Histochemistry of diabetic sciatic nerve revealed marked degeneration.n NOS and i NOS immunoreactivities were increased,while S-100 immunoreactivity(Schwann cell marker) was decreased in sciatic nerve.Apocynin treatment reversed these changes dose-dependently.In conclusion,decreased pain threshold of diabetic rats was accompanied by increased NOX and catalase expression in the spinal cord and increased degeneration in the sciatic nerve characterized by increased NOS expression and Schwann cell loss.Apocynin treatment attenuates neuropathic pain by decelerating the increased oxidative stress-mediated pathogenesis in diabetic rats. | Murat Olukman Aytül onal Fatma Gül celenk Yigit Uyankgil Türker cavusoglu Neslihan Düzenli Sibel ülker | 2018 | Neural Regeneration Research2018，13，9： | 4 |
| 2 | Roles of β-amylase and starch breakdown during temperatures stress显示文摘 | FATMA K DONG Y S CHARLES L G | 2006 | Physiologia Plantarum2006，126，1： | 1 |
| 3 | Roles ofβ-amylaseand starch breakdown during temperatures stress显示文摘 | Fatma K Dong Y S Charles L G | 2006 | Physiol plan-tarum2006，126，： | 1 |
| 4 | Adapter protein 14- 3-3 is required for a presynaptic form of LIP in the cerebellum 显示文摘 | Fatma Simsek-Duran Davic J L Gyorgy L | 2004 | Nature Neuroscience2004，7，： | 1 |
| 5 | Roles of β-amylase andstarch breakdown during temperatures stress显示文摘 | Fatma K Dong Y S Chariles L G | 2006 | Physiolplantarum2006，126，： | 1 |
| 6 | Application of chlorophyll fluorescence for the diagnosis of salt stress in tomato 'Solanum lycopersicum (variety Rio Grande)'显示文摘 | Zribi L Farina G Fatma R | 2009 | Scientia Horticulturae2009，120，： | 1 |
| 7 | Application of chlorophyll fluorescence for the diagnosis of salt stress in tomato 'Solanum lycopersicum (variety Rio Grande)'显示文摘 | Zribi L Fatma G Fatma R | 2009 | Scientia Horticulturae2009，120，3： | 1 |
| 8 | RNA interference of Arabidopsis beta -amylase 8 prevents maltose accumulation upon cold shock and increase sensitivity of PSII photochemical efficiency to freezing stress 显示文摘 | Fatma K Guy Charles L | 2005 | The Plant Journal2005，，44： | 1 |
| 9 | Application of chlorophyll fluorescence for the diagnosis of salt stress in tomato “Solanum lycopersicum (variety Rio Grande)”显示文摘 | Zribi L Fatma G Fatma R | 2009 | Scientia Horticulturae2009，120，： | 1 |
| 10 | Does treatment affect the levels of serum Interleukin-6, Interleukin-8 and procalcitonin in diabetic foot infection? A pilot study显示文摘 | Fatma Aybala Altay ?rfan ?encan G?nül ?i?ek ?entürk Mustafa Altay Selda Güvenman Selman ünverdi Ziya Cibali A??kg?z | 2012 | Journal of Diabetes and Its Complications2012，，3： | 1 |
| 11 | Antioxidant activity of benzoxazolinonic and benzothiazolinonic derivatives in the LDL oxidation model显示文摘 | Isma?l Yekini Fatma Hammoudi Fran?oise Martin-Nizard Sa?d Yous Nicolas Lebegue Pascal Berthelot Pascal Carato | 2009 | Bioorganic & Medicinal Chemistry2009，，22： | 1 |
| 12 | Performance status of patients is the major prognostic factor at all stages of pancreatic cancer显示文摘 | Faruk Tas Fatma Sen Hatice Odabas Leyla K?l?c Serkan Kesk?n Ibrah?m Y?ld?z | 2013 | International Journal of Clinical Oncology2013，，5： | 1 |
| 13 | Application of chlorophyll fluorescence for the diagnosis of salt stress in tomato“Solanum lycopersicum(variety Rio Grande)”显示文摘 | ZRIBI L FATMA G FATMA R | 2009 | Scientia Horticulturae2009，120，3： | 1 |
| 14 | Analysis of Teachers’Approaches to Distance Education显示文摘 | Fatma Kübra?elen Aygül?elik Süleyman Sadi Seferoglu | 2013 | Procedia-Social and Behavioral Sciences2013，，8： | 1 |
| 15 | Targeted chromosomal deletions and inversions in zebrafish 显示文摘 | Ankit Gupta Victoria L Hall Fatma O K | 2013 | Gennme Research2013，23，： | 1 |
| 16 | Food Safety Education Using an Interactive Multimedia Kiosk in a WIC Setting:Correlates of Client Satisfaction and Practical Issues显示文摘 | Mary Jo Trepka Frederick L Newman Fatma G Huffman | 2010 | Journal of Nutrition Education and Behavior2010，42，3： | 1 |
| 17 | Indoor Air Pollutants and Health in the United Arab Emirates显示文摘 | Yeatts Karin B El-Sadig Mohamed Leith David Kalsbeek William Al-Maskari Fatma Couper David Funk William E Zoubeidi Taoufik Chan Ronna L Trent Chris B Davidson Christopher A Boundy Maryanne G Kassab Maamoon M Hasan Mohamed Y Rusyn Ivan Gibso | 2012 | EN2012，，5： | 1 |
| 18 | Roles of β-amylase and starch breakdown during temperatures stress显示文摘 | FATMA K DONG Y S CHARLES L G | 2006 | Physi- ol plantarum2006，126，： | 1 |
| 19 | Roles of β-amylase and starch breakdown during temperatures stress显示文摘 | FATMA K DONG Y S CHARLES L G | 2006 | Physiol Plantarum2006，，126： | 1 |
| 20 | Roles of β-amylase and starch breakdown during temperatures stress显示文摘 | Kaplan Fatma Dong Yul Sung Guy Charles L | 2006 | Physlologla Plantarum2006，126，1： | 1 |
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