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| 1 | Fluid therapy for severe acute pancreatitis in acute response stage显示文摘为严重尖锐胰腺炎(树液) 的背景液体治疗不应该仅仅解决血体积的缺乏,而且在尖锐反应舞台阻止液体隐遁。最新,在那里,为液体治疗的策略没奉献给树液。那么,这研究被瞄准在树液的预后上调查液体治疗治疗的效果。76 个病人在 72 小时树液发作以内根据标准有希望地被招收的方法。他们随机被分到一个快速的液体扩大组(组我, n=36 ) 并且一个控制液体扩大组(组, n=40 ) 。血液动力学的混乱快速是任何一个(液体注入率是 10-15 ml 吗?? | MAO En-qiang TANG Yao-qing FEI Jian QIN Shuai WU Jun LI Lei MIN Dong ZHANG Sheng-dao | 2009 | Chinese Medical Journal2009，，2： | 89 |
| 2 | Black carbon aerosols and their radiative properties in the Pearl River Delta region显示文摘The climatic and environmental effects of atmospheric aerosols are a hot topic in global science community, and radiative properties of the aerosols are one of the important parameters in assessing climatic change. Here we studied the black carbon concentration and absorption coefficient measured with aethalometers, scattering coefficient measured with nephelometers, and single scattering albedo derived at an atmospheric composition watch station in Guangzhou from 2004 to 2007. Our main results are as follows. The data of black carbon concentration and absorption coefficients measured with instruments cannot be directly used until they are measured in parallel with internationally accepted instruments for comparison, calibration, and reduction. After evaluation of the data, the result shows that the monthly mean of BC concentration varies 3.1―14.8 μg·m-3 and the concentration decreases by about 1 μg·m-3 in average over the four years; It is higher in the dry season with a multi-year mean of 8.9 μg/m3 and lower in the rainy season with a multi-year mean of 8.0 μg·m-3; The extreme maximum of monthly mean concentration occurred in December 2004 and extreme minimum in July 2007, and a 4-year mean is 8.4 μg·m-3. It is also shown that monthly mean scattering coefficient derived varies 129 -565 Mm-1, monthly mean absorption coefficient 32-139 Mm-1, and monthly mean single scattering albedo 0.71-0.91, with annual mean values of 0.80, 0.82, 0.79 and 0.84 for 2004, 2005, 2006 and 2007, respectively. Three instruments were used to take simultaneous measurements of BC in PM10, PM2.5, and PM1 and the results showed that PM2.5 took up about 90% of PM10 and PM1 accounted for about 68% of PM2.5, and BC aerosols are mainly present in fine particulates. The variability of BC concentrations is quite consistent between the Nancun station (141 m above sea level) and the Panyu station (13 m above sea level), which are 8 km apart from each other. The concentration in higher altitude station (Panyu) is consistently lower than the lower altitude station (Nancun), and the difference of annual mean is about 4 μg·m-3. | WU Dui MAO JieTai DENG XueJiao TIE XueXi ZHANG YuanHang ZENG LiMin LI Fei TAN HaoBo BI XueYan HUANG XiaoYing CHEN Jing DENG Tao | 2009 | Science China Earth Sciences2009，52，8： | 58 |
| 3 | Rapid hemodilution is associated with increased sepsis and mortality among patients with severe acute pancreatitis显示文摘背景 Hemoconcentration 可以是决定严重尖锐胰腺炎(树液) 的前进的一个重要因素。另外, biomarkers 可能在在树液预言随后的坏死是有用的,这被建议了。然而,在一个短术语的 hemodilution 是否能改进结果,仍然是不明确的。我们试图与 SAP.Methods 在病人的结果上调查快速的 hemodilution 的效果 115 个病人在 24 小时树液以内根据标准有希望地被招收发作。病人们随机被分到快速的 hemodilution 也(分血器(HCT )<35% , n=56 ) 或慢 hemodilution (HCT 235% , n=59 ) 在 48 小时发作以内。Balthazar CT 分数在承认上被计算,白天 7,和白天 14,在疾病的发作以后。为介绍的败血的时间间隔,在 28 天和在里面医院幸存率以内的败血的发生是液体的数量在快速的 hemodilution 使用了的 determined.Results 显著地在慢 hemodilution 多于那被使用(P < 0.05 ) 在承认天,第一天,和第二天。以在在第一个星期期间的不同时间的分血器,氧化索引, pH 价值, APACHE II 分数和机关机能障碍快速、慢的 hemodilution 组之间有重要差别。在到在快速的 hemodilution 的败血的时间间隔有重要差别(( 7.4 1.9 )天)与慢 hemodilution 组相比(( 10.2 2.3 )天),并且败血(78.6%)的发生在快速的组与相比是更高的慢(57.6%)在开始的 28 天内。慢 hemodilution 组(84.7%) 的幸存率比快速的 hemodilution 好(66.1% 。P < 0.05 ) 快速的 hemodilution 能增加的 .Conclusions 在 28 天和在里面医院死亡以内的败血的发生。分血器应该在尖锐反应阶段在 30%-40% 之间被维持。 | MAO En-qiang FEI Jian PENG Yi-bing HUANG Jie TANG Yao-qing ZHANG Sheng-dao | 2010 | Chinese Medical Journal2010，，13： | 43 |
| 4 | Low Root Zone Temperature Limits Nutrient Effects on Cucumber Seedling Growth and Induces Adversity Physiological Response显示文摘Effects of root-zone temperatures (RZT) (12°C-RZT and 20°C-RZT) and different N, P, and K nutrient regimes on the growth, reactive oxygen species (ROS), and antioxidant enzyme in cucumber seedlings were investigated in hydroponics. Strong interactions were observed between RZT and nutrient on the dry weight (P=0.001), root length (P=0.001) and leaf area (P=0.05). Plant dry weights were suppressed at low RZT of 12°C, while higher biomass and growth of cucumber seedlings were produced at elevated RZT of 20°C under each nutrient treatment. Growth indexes (plant height, internode length, root length, and leaf area) at 12°C-RZT had less difference among nutrient treatments, but greater response was obtained for different nutrients at high RZT. RZT had larger effects (P=0.001) on cucumber seedling growth than nutrients. In addition, N was more effective nutrients to plant growth than P and K under low root temperature to plant growth. Higher hydrogen peroxide (H 2 O 2 ), malondialdehyde (MDA), soluble sugar (SS) contents in leaves were observed at 12°C-RZT in all nutrient treatments than those at 20°C-RZT, indicating the chilling adversity damaged to plant growth. In general, antioxidant enzyme had larger response under low root-zone temperature. Superoxide dismutase (SOD) activities were higher in both leaves and roots while peroxidase (POD) and catalase (CAT) showed large different action in leaves and roots at both the two root-zone temperature. | YAN Qiu-yan DUAN Zeng-qiang MAO Jing-dong LI Xun DONG Fei | 2013 | Journal of Integrative Agriculture2013，12，8： | 15 |
| 5 | Profiling of the transcriptome of Porphyra yezoensis with Solexa sequencing technology显示文摘With high-throughput Solexa sequencing technology,we profiled Porphyra yezoensis transcriptomes from 8 different samples. More than 1200 megabases from 13333334 quality paired-end reads were generated,which were assembled into 31538 unigenes. Blast analysis showed that 56.7%unigenes were novel,which represented the specific genes of Porphyra and/or rhodophytes. Several hundreds of unigenes related to stress tolerance were discovered,including genes related to desiccation-(211) and high light-tolerance(31) ,flavonoid biosynthesis(10) ,reactive oxygen scavenging(48) and other stress-tolerance processes(208) ,which indicated there existed complex and diversity modes of stress tolerance in this species.A complete set of essential genes involved in the C3-(57) and C4-(44) carbon fixation pathway(except pyruvate phosphate dikinase) were discovered,which not only proved that they were actively transcribed but also clearly outlined the panoptic view of carbon fixation in Porphyra.Moreover,by statistically analyzing the types,proportions and frequencies of the interspersed repeats(TEs) and simple sequence repeats(SSRs) ,we discovered that the top three types of TEs were all retrotransposons and the trinucleotide was the absolute predominant type among SSRs,promoting our understanding of structural characteristics of the transcriptome.This study substantially improved the global view of the Porphyra genome and provided a valuable resource for future research. | YANG Hui MAO YunXiang KONG FanNa YANG GuanPin MA Fei WANG Li | 2011 | Chinese Science Bulletin2011，56，20： | 13 |
| 6 | Clinical features and outcomes of patients with severe acute pancreatitis complicated with gangrenous cholecystitis显示文摘BACKGROUND: The effects of gangrenous cholecystitis (GC) and consequent surgical interventions on the clinical outcomes and prognosis of patients with severe acute pancreatitis are not clear. The present study was to characterize the clinical outcomes of patients with severe acute pancreatitis complicated with GC. METHODS: We retrospectively analyzed 253 consecutive patients hospitalized for acute pancreatitis in intensive care unit. Among them, 68 were diagnosed as having severe acute pancreatitis; 10 out of the 68 patients had GC. We compared these 10 patients with GC and 58 patients without GC. The indices analyzed included sepsis/septic shock, pancreatic encephalopathy, acute respiratory distress syndrome, acute renal failure, multiple organ dysfunction syndrome, and death. RESULTS: Specific CT images of GC in patients with severe acute pancreatitis included enlarged and high-tensioned gallbladder, wall thickening, lumenal emphysema, discontinuous and/or irregular enhancement of mucosa, and pericholecystic effusion. The rates of severe sepsis/septic shock (70.0% vs 24.1%, P<0.01), pancreatic encephalopathy (50.0% vs 17.2%, P<0.05), acute respiratory distress syndrome (90.0% vs 41.4%, P<0.01), multiple organ dysfunction syndrome (70.0% vs 24.1%, P<0.01), acute renal failure (40.0% vs 27.6%, P<0.05), and death (40.0% vs 13.8%, P<0.05) were significantly higher in patients with GC than in those without GC.CONCLUSION: CT scans can help to identify early GC in patients with severe acute pancreatitis; early diagnosis and intervention for patients with GC can reduce morbidity and mortality. | Er-Zhen Chen Jie Huang Zhi-Wei Xu Jian Fei En-Qiang Mao Sheng-Dao Zhang | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 13 |
| 7 | Casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer cells显示文摘Objective:To assess if casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer ceils.Methods:Human non-small-cell lung carcinoma cell lines H460,AS49 and H157 were cultured in vitro.The cytotoxic activities were determined using MTT assay.The apoptotic cells death was examined by flow cytometry using PI staining and DMA agarose gel electrophoresis.The activities of caspase-3, -8 and -9 were measured via ELISA.Cellular fractionation was determined by flow cytometry to assess release of cytochrome c and the mitochondrial transmembrane potential.Bcl-2/Bcl-XL/ XIAP/Bid/ DR5 and DR4 proteins were analyzed using western blot.Results:The concentrations required for a 50%decrease in cell growth(IC50) ranged from 1.8 to 3.2 Jt M.Casticin induced rapid apoptosis and triggered a series of effects associated with apoptosis by way of mitochondrial pathway,including the depolarization of the mitochondrial membrane,release of cytochrome c from mitochondria,activation of procaspase-9 and -3,and increase of DNA fragments.Moreover, the pan caspase inhibitor zVAD-FMK and the caspase-3 inhibitor zOEVD-FMK suppressed casticin-induced apoptosis.In addition,casticin induced XIAP and Bcl-XL down-regulation, Bax upregulation and Bid clearage.In H157 cell line,casticin increased expression of DRS at protein levels but not affect the expression of DR4.The prelreatmenl with DR5/Fc chimera protein effectively attenuated casticin-induced apoptosis in H157 cells.No correlation was found between cell sensitivity to casticin and that to p53 status,suggesting that casticin induce a p53- independent apoptosis.Conclusions:Our results demonstrate that casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DRS in human lung cancer cells. | Yuan Zhou Yi Peng Qi-Qi Mao Xia Li Ming-Wu Chen Ting Su Li Tian Nai-Quan Mao Ling-Zhi Long Mei-Fang Quan Fei Liu Su-Fang Zhou Yong-Xiang Zhao | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，5： | 11 |
| 8 | Geographic variation of chloroplast DNA in Platycarya strobilacea (Juglandaceae)显示文摘摘要 monotypic 类 Platycarya (Juglandaceae ) 是在东亚的最普遍的适度的树种类之一。在这研究,我们实现了用叶绿体 DNA (cpDNA )(psbA-trnH 和 atpB-rbcL intergenic 分隔符) 的学习在 Platycarya strobilacea 上定序的 phylogeographical,主要 refugia 和移植发送以便识别种类的地点。P 的 180 个个人的一个总数。从从中国和 Jeju 岛(朝鲜) 的 27 张人口的 stobilacea 是镇定的。结果揭示了那 P。strobilacea 为二个 intergenic 分隔符和高基因差异有 35 haplotypes (hT= 0.926 ) 。haplotypes 的这令人惊讶地高的差异显示它的长进化的历史,它与以前的种系发生的分析和石块记录一致。重要 cpDNA 人口分被检测(GST= 0.720;NST= 0.862 ) ,通过在人口和重要 phylogeographical 之中的种子的周期性的基因流动的建议底层组织(NST > GST, P < 0.05 ) 。35 chlorotypes 的种系发生的关系的构造检测了四主要 cpDNA clades。用野兽的分叉标明日期分析建议主要 cpDNA clades 的分叉以前发生了中新世。人口统计的分析显示东方 clade 经历了局部性的人口统计的扩大。分子的种系发生的数据和 haplotypes 的地理分发,通过第四级的气候的摆动在中国在大多数它的当前的范围建议多重冰川的 refugia 的存在。 | Shi-Chao CHEN Li ZHANG Jie ZENG Fei SHI Hong YANG Yun-Rui MAO Cheng-Xin FU | 2012 | Journal of Systematics and Evolution2012，50，4： | 10 |
| 9 | Extreme precipitation events in East China and associated moisture transport pathways显示文摘Interannual variation of summer precipitation in East China, and frequency of rainstorms during the monsoon season from 1961 to 2010, are analyzed in this study. It is found that the two variables show opposite trends on a decadal time scale: frequency of rainstorms increases significantly after the 1990 s, while summer precipitation in East China decreases during the same period. Analysis of the spatial distribution of summer rainstorm frequency from 1961 to 2010 indicates that it decreases from the southeast to the northwest at the east edge of the large-scale topography associated with the plateaus. Spatial distribution of rainstorms with daily rainfall greater than 50 mm is characterized by a 'high in the southeast and low in the northwest' pattern, similar to the staircase distribution of the topography. However, the spatial distribution of variation in both summer precipitation and frequency of extreme rainstorms under global warming differs significantly from the three-step staircase topography. It is shown that moisture characteristics of summer precipitation and extreme rainstorms during the monsoon season in East China, including moisture transport pathways, moist flow pattern, and spatial structure of the merging area of moist flows, differ significantly. Areas of frequent rainstorms include the Yangtze River Valley and South China. Column-integrated moisture transport and its spatial structure could be summarized as a 'merging' of three branches of intense moist flows from low and middle latitude oceans, and 'convergence' of column-integrated moisture fluxes. The merging area for moist flow associated with rainstorms in the high frequency region is located slightly to the south of the monsoonal precipitation or non-rainstorm precipitation, with significantly strong moisture convergence. In addition, the summer moist flow pattern in East China has a great influence on the frequency of extreme rainstorms. Moisture flux vectors in the region of frequent rainstorms correspond to vortical flow pattern. A comparison of moisture flux vectors associated with non-rainstorms and rainstorms indicates that the moist vortex associated with rainstorms is smaller in size and located to the south of the precipitation maximum, while the moist vortex associated with non-rainstorms is larger and located to the north. It is shown that column-integrated moist transport vortices and the structure of moist flux convergence have significant impacts on the north-south oscillation of frequent rainstorm areas in East China, which is synchronized with the maximum vorticity of moisture transport and the minimum of convergence on the decadal time scale. Synthesis of moisture transport pathways and related circulation impacts leads to a conceptual model of moisture flow associated with rainstorms. | ZHAO Yang XU XiangDe ZHAO TianLiang XU HongXiong MAO Fei SUN Han WANG YuHong | 2016 | Science China Earth Sciences2016，59，9： | 8 |
| 10 | Permafrost warming along the Mo'he-Jiagedaqi section of the China-Russia crude oil pipeline显示文摘The permafrost along the China-Russia Crude Oil Pipeline(CRCOP) is degrading since the pipeline operation in 2011. Heat dissipated from the pipeline, climate warming and anthropogenic activities leads to permafrost warming. The processes of permafrost warming along the CRCOP were studied based on the monitoring of air and soil temperatures, and electrical resistivity tomography(ERT) surveys. Results show that:(1) the mean annual air temperature(MAAT) in permafrost regions along the CRCOP increased with a rate of 0.21°C/10a–0.40°C/10 a during the past five decades;(2) the mean annual ground temperature(MAGT, at-15 m depth) of undisturbed permafrost increased by 0.2°C and the natural permafrost table remained unchanged due to the zero-curtain effect;(3) permafrost surrounding the uninsulated pipeline right-of-way warmed significantly compared with that in a natural site. During 2012–2017, the MAGT and the artificial permafrost table, 2 m away from the pipeline centerline, increased at rates of 0.063°C/a and 1.0 m/a. The thaw bulb developed around the pipe and exhibits a faster lateral expansion;(4) 80-mm-thick insulation could reduce the heat exchange between the pipeline and underlying permafrost and then keep the permafrost and pipe stable. The MAGT and the artificial permafrost table, 4.8 m away from the center line of the pipeline, increased by 0.3°C/a and 0.43 m/a, respectively. Due to the heat disturbance caused by warm oil, the degradation of wetland, controlled burn each autumn and climate warming, the permafrost extent reduced and warmed significantly along the CRCOP route. Field observations provide basic data to clarify the interactions between CRCOP and permafrost degradation and environmental effects in the context of climate change. | WANG Fei LI Guo-yu MA Wei MAO Yun-cheng MU Yan-hu SERBAN Mihaela CAI Yong-jun | 2019 | Journal of Mountain Science2019，16，2： | 8 |
| 11 | A detection method for logic functions suitable for dual-logic synthesis显示文摘Logic functions can be implemented in either AND/OR/NOT-based traditional Boolean(TB) logic or AND/XOR-based Reed-Muller(RM) logic.To the majority of logic functions,it will be beneficial to be partially implemented in both TB logic and RM logic,called dual-logic.In this paper,a detection condition favoring dual-logic synthesis is proposed.A corresponding detection algorithm is developed and implemented in C.The algorithm is applied to test a set of MCNC91 benchmarks for verifying the algorithm.The results show that the proposed algorithm is more efficient than published ones. | Yinshui Xia Fei Sun Keyi Mao | 2009 | Progress in Natural Science:Materials International2009，19，10： | 7 |
| 12 | A cohort autopsy study defines COVID-19 systemic pathogenesis显示文摘Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by dysfunction of the lungs and extrapulmonary organs.However,the organotropism of SARS-CoV-2 and the port of virus entry for systemic dissemination remain largely unknown.We profiled 26 COVID-19 autopsy cases from four cohorts in Wuhan,China,and determined the systemic distribution of SARS-CoV-2. | Xiao-Hong Yao Tao Luo Yu Shi Zhi-Cheng He Rui Tang Pei-Pei Zhang Jun Cai Xiang-Dong Zhou Dong-Po Jiang Xiao-Chun Fei Xue-Quan Huang Lei Zhao Heng Zhang Hai-Bo Wu Yong Ren Zhen-Hua Liu Hua-Rong Zhang Cong Chen Wen-Juan Fu Heng Li Xin-Yi Xia Rong Chen Yan Wang Xin-Dong Liu Chang-Lin Yin Ze-Xuan Yan Juan Wang Rui Jing Tai-Sheng Li Wei-Qin Li Chao-Fu Wang Yan-Qing Ding Qing Mao Ding-Yu Zhang Shu-Yang Zhang Yi-Fang Ping Xiu-Wu Bian | 2021 | Cell Research2021，31，8： | 7 |
| 13 | Realization of quantum discrete Fourier transform with NMR显示文摘The pulse sequences of the logic operations used in quantum discrete Fourier transform are designed for the experiment of nuclear magnetic resonance(NMR), and 2-qubit discrete Fourier transforms are implemented experimentally with NMR. The experimental errors are examined and methods for reducing the errors are proposed. | FANG Ximing ZHU Xiwen FENG Mang MAO Xi’an DU Fei | 2000 | Chinese Science Bulletin2000，45，12： | 7 |
| 14 | Chemical composition and structural identification of primary carbides in as-cast H13 steel显示文摘The aim of this study was to characterize the primary carbides formed in as-cast H13 steel. The composition, morphology, type, and size of primary carbides in as-cast H13 steel were investigated by optical microscope (OM), field emission scanning electron microscopy (FE-SEM), electron back-scattered diffraction (EBSD), and X-ray diffraction (XRD) analysis. The number of primary carbides was investigated by ASPEX automated inclusion analysis system. The results indicated that primary carbides in as-cast H13 steel are mainly composed of Cr, Mo, V, and Ti, and there exist four kinds of primary carbides in the interdendritic zones of H13 steel, which are stripy Mo–Cr-rich M2C, eutectic Mo–Cr-rich M2C, V-rich MC, and V-rich MC with Ti and N. Thermodynamic calculation indicated that M2C precipitates in liquid phase at solid fractions larger than 0.99, while MC precipitates in liquid phase at solid fractions larger than 0.96. Statistical results indicated that the number of M2C is much greater than the number of other kinds of primary carbides. Most primary carbides are blocky, with lengths of no more than 10 μm and a length/width ratio of no more than 3. The large primary carbides in as-cast H13 steel are mainly M2C. | Ming-tao Mao Han-jie Guo Fei Wang Xiao-lin Sun | 2019 | International Journal of Minerals,Metallurgy and Materials2019，26，7： | 7 |
| 15 | Two-in-one:A pooled analysis of primary hepatic neuroendocrine carcinoma combine d/collide d with hepatocellular carcinoma显示文摘To the Editor:Primary hepatic neuroendocrine carcinoma(PHNEC)combined/collided with hepatocellular carcinoma(HCC)is a rare and intriguing disease with characteristics of two histologically different cancers.Usually,a combined type refers to the cases in which hepatic neuroendocrine carcinoma(HNEC)and HCC components intermingle with each other and cannot be clearly separated in the transitional areas,while a collision type refers to those in which the two distinct cancers occurred simultaneously and independently.Sometimes it is difficult to readily distinguish these two types.We searched PubMed,Medline,China Science Periodical Database,and VIP Database with the publication from January 1980 to January 2019,using the keywords(“hepatic neuroendocrine carcinoma”or“HNEC”)and(“hepatocellular carcinoma”or“HCC”).After manually excluding records on secondary HNEC and other types of liver cancer,a total of 28 cases in 24 reports[1–24]were identified and summarized in Table 1. | Jia-Xi Mao Fei Teng Ke-Yan Sun Cong Liu Guo-Shan Ding Wen-Yuan Guo | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，4： | 6 |
| 16 | Two case reports and literature review for hepatic epithelioid angiomyolipoma: Pitfall of misdiagnosis显示文摘BACKGROUND Hepatic epithelioid angiomyolipoma(HEAML) is a rare liver disease and is easily misdiagnosed. Enhanced recognition of HEAML is beneficial to the differential diagnosis of rare liver diseases.CASE SUMMARY We presented two cases of HEAML in Changzheng Hospital, Naval Medical University, and then collected and analyzed all reports about HEAML recorded in PubMed, MEDLINE, China Science Periodical Database, and VIP database from January 2000 to March 2018. A total of 409 cases of HEAML in 97 reports were collected, with a ratio of men to women of 1:4.84 and an age range from 12 years to 80 years(median 44 years). Among the patients with clinical symptoms mentioned, 61.93%(205/331) were asymptomatic, 34.74%(115/331) showed upper or right upper quadrant abdomen discomfort, while a few of them showed abdominal mass, gastrointestinal symptoms, low fever, or weight loss. The misdiagnosis rate of HEAML was as high as 40.34%(165/409) due to its nonspecific imaging findings. Most of the tumors were solitary and round in morphology, with clear boundaries. Ultrasound scan indicated low echo with internal nonuniformity and rich blood supply in most cases. Computer tomography/magnetic resonance imaging enhanced scan showed varied characteristics. The ratio of fast wash-in and fast wash-out, fast wash-in and slow wash-out, and delayed enhancement was roughly 4:5:1. A definite diagnosis of HEAML depended on the pathological findings of the epithelioid cells in lesions and the expression of human melanoma black 45, smooth muscle actin,melanoma antigen, and actin by immunohistochemical staining. HEAML had a relatively low malignant rate of 3.91%. However, surgical resection was the main treatment for HEAML, due to the difficulty diagnosing before operation.CONCLUSION HEAML is a rare and easily misdiagnosed disease, and it should be diagnosed carefully, taking into account clinical course, imaging, pathological,and immunohistochemical findings. | Jia-Xi Mao Fei Teng Cong Liu Hang Yuan Ke-Yan Sun You Zou Jia-Yong Dong Jun-Song Ji Jun-Feng Dong Hong Fu Guo-Shan Ding Wen-Yuan Guo | 2019 | World Journal of Clinical Cases2019，7，8： | 6 |
| 17 | Nitazoxanide,an anti-parasitic drug,efficiently ameliorates learning and memory impairments in AD model mice显示文摘The pathogenesis of Alzheimer's disease(AD)is characterized by both accumulation ofβ-amyloid(AB)plaque and formation of neurofirillary tangles in the brain.Recent evidence shows that autophagy activation may potently promote intraellular Aβclearance.Thus targeting autophagy becomes a promising strategy for discovery of drug leads against AD.In the present study,we established a platform to discover autophagy stimulator and screened the lab in-house FDA-approved drug library.We found thatanti-parasitic drug nitazoxanide(NTZ)was an autophagy activator and could efficiently improve learning and memory impairmentsin APP/PS1 transgenic mice.In BV2 cells and primary cortical astrocytes,NTZ stimulated autophagy and promoted Aβclearance by inhibiting both P12K/AKT/mTOR/ULK1 and NQO1/mTOR/ULK1 signaling pathways;NTZ treatment attenuated LPS-induced inflammation by inhibiting PI3K/AKT/IKB/NFKB signaling.In SH-SY5Y cells and primary cortical neurons,NTZ treatment restrained tau hyperphosphorylation through inhibition of PI3K/AKT/GSK3βpathway.The beneficial effects and related signaling mechanisms from the in vitro studies were also observed in APP/PS1 transgenic mice following administration of NTZ(90 mg·kg^-1d,ig)for100 days.Furthermore,NTZ administration decreased Aβlevel and senile plaque formation in the hippocampus and cerebral cortexof APP/PS1 transgenic mice,and improved learning and memory impairments in Morris water maze assay.In conclusion,our results highlight the potential of NTZ in the treatment of AD. | Lei Fan Xiao-xia Qiu Zhi-yuan Zhu Jian-lu Lv Jian Lu Fei Mao Jin Zhu Jia-ying Wang Xiao-wei Guan Jing Chen Jin Ren Ji-ming Ye Yong-hua Zhao Jian Li Xu Shen | 2019 | Acta Pharmacologica Sinica2019，40，10： | 6 |
| 18 | Hydrogen peroxide functions as a secondary messenger for brassinosteroids-induced CO_2 assimilation and carbohydrate metabolism in Cucumis sativus显示文摘Brassinosteroids(BRs) are potent regulators of photosynthesis and crop yield in agricultural crops;however,the mechanism by which BRs increase photosynthesis is not fully understood.Here,we show that foliar application of 24-epibrassinolide(EBR) resulted in increases in CO 2 assimilation,hydrogen peroxide(H 2 O 2) accumulation,and leaf area in cucumber.H 2 O 2 treatment induced increases in CO 2 assimilation whilst inhibition of the H 2 O 2 accumulation by its generation inhibitor or scavenger completely abolished EBR-induced CO 2 assimilation.Increases of light harvesting due to larger leaf areas in EBR-and H 2 O 2-treated plants were accompanied by increases in the photochemical efficiency of photosystem II(Φ PSII) and photochemical quenching coefficient(q P).EBR and H 2 O 2 both activated carboxylation efficiency of ribulose-1,5-bisphosphate oxygenase/carboxylase(Rubisco) from analysis of CO 2 response curve and in vitro measurement of Rubisco activities.Moreover,EBR and H 2 O 2 increased contents of total soluble sugar,sucrose,hexose,and starch,followed by enhanced activities of sugar metabolism such as sucrose phosphate synthase,sucrose synthase,and invertase.Interestingly,expression of transcripts of enzymes involved in starch and sugar utilization were inhibited by EBR and H 2 O 2.However,the effects of EBR on carbohydrate metabolisms were reversed by the H 2 O 2 generation inhibitor diphenyleneodonium(DPI) or scavenger dimethylthiourea(DMTU) pretreatment.All of these results indicate that H 2 O 2 functions as a secondary messenger for EBR-induced CO 2 assimilation and carbohydrate metabolism in cucumber plants.Our study confirms that H 2 O 2 mediates the regulation of photosynthesis by BRs and suggests that EBR and H 2 O 2 regulate Calvin cycle and sugar metabolism via redox signaling and thus increase the photosynthetic potential and yield of crops. | Yu-ping JIANG Fei CHENG Yan-hong ZHOU Xiao-jian XIA Wei-hua MAO Kai SHI Zhi-xiang CHEN Jing-quan YU | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，10： | 6 |
| 19 | Vitamin C Attenuates Hemorrhagic Shock-induced Dendritic Cell-specific Intercellular Adhesion Molecule 3-grabbing Nonintegrin Expression in Tubular Epithelial Cells and Renal Injury in Rats显示文摘 | Li Ma Jian Fei Ying Chen Bing Zhao Zhi-Tao Yang Lu Wang Hui-Qiu Sheng Er-Zhen Chen En-Qiang Mao | 2016 | Chinese Medical Journal2016，，14： | 5 |
| 20 | Back Propagation neural network modeling for warpage prediction and optimization of plastic products during injection molding显示文摘 | Fei Yin Huajie Mao Lin Hua Wei Guo Maosheng Shu | 2010 | Materials and Design2010，，4： | 4 |
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