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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | A prospective feasibility study of sub-millisievert abdominopelvic CT using iterative reconstruction in Crohn’s disease显示文摘 | Siobhan B O’Neill Patrick D Mc Laughlin Lee Crush Owen J O’Connor Sebastian R Mc Williams Orla Craig Anne Marie Mc Garrigle Fiona O’Neill Jackie Bye Max F. Ryan Fergus Shanahan Michael M Maher | 2013 | European Radiology2013，，： | 2 |
| 3 | Lanthanum Chromite-based Materials for Solid Oxide Fuel Cell Interconnects显示文摘 | Fergus J W | 2004 | Solid State lonics2004，171，： | 1 |
| 4 | Electrolytes for solid oxide fuel cells 显示文摘 | FERGUS J W | 2006 | Journalof Power Sources2006，162，： | 1 |
| 5 | Recent developments in cathode materials for lithium ion batteries显示文摘 | FERGUS J W | 2010 | Journal of Power Sources2010，195，： | 1 |
| 6 | Electrolytes for Solid Oxide Fuel Cells 显示文摘 | Fergus J W | 2006 | Power Sources2006，162，： | 1 |
| 7 | Silicon-carbide/boron-containing coatings for the oxidation protection of graphite显示文摘 | FERGUS J WORRELL W | 1995 | Carbon1995，33，4： | 1 |
| 8 | Perovskite oxides for semiconductor-based gas sensors显示文摘 | Fergus J W | | 0，，02： | 1 |
| 9 | Recent developments in cathode materials for lithi-um ion batteries 显示文摘 | FERGUS J W | 2010 | Journal of Power Sources2010，195，4： | 1 |
| 10 | Ceramic and polymeric solid electrolytes for lithium-ion batteries 显示文摘 | Fergus J W | 2010 | J Power Sources2010，195，15： | 1 |
| 11 | Analysis of effects of the state of charge on the formation and growth of the deposit layer on graphite electrode of pouch type lithium ion polymer batteries显示文摘 | Agubra V A Fergus J W Fu R J | 2014 | Journal of Power Sources2014，270，： | 1 |
| 12 | The effect of battery potential and charge rate on the decomposition reaction on the anode electrode of lithium ion polymer battery显示文摘 | Agubra V Fergus J W Rujian F | 2014 | ECS Transactions2014，61，8： | 1 |
| 13 | Electrolytes for Solid Oxide Fuel Cells显示文摘 | Fergus J W | 2006 | Journal of Power Sources2006，162，： | 1 |
| 14 | The location of guaiacyl and syringyl lignins in birch xylem tissue显示文摘 | Fergus B J Goring D A I | 1970 | Holzforschung1970，24，4： | 1 |
| 15 | Oxide anode materials for solid oxide fuel cells 显示文摘 | FERGUS J W | 2006 | Solid State Ionics2006，177，17： | 1 |
| 16 | Zirconia and Pyrochlore Oxides for Thermal Barrier Coatings in Gas Turbine Engines显示文摘 | Fergus J W | 2014 | Metallurgical and Materials Transactions E2014，6，： | 1 |
| 17 | Recent developments in cathode materials for lithium ion batteries显示文摘 | Fergus J W | 2010 | Journal of Power Sources2010，195，4： | 1 |
| 18 | Electrolytes for solid oxide fuel cells显示文摘 | Fergus J W | | 0，，01： | 1 |
| 19 | Recent developments in cathode materials for lithium ion batteries显示文摘 | Fergus J W | 2010 | J Power Sources2010，195，4： | 1 |
| 20 | Mteallic interconnects for solid oxide fuel cells显示文摘 | Fergus J W | 2005 | Materials Science and Engineering2005，397，： | 1 |
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