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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | Management of hepatitis C in patients with chronic kidney disease显示文摘Hepatitis C virus(HCV) infection is highly prevalent among chronic kidney disease(CKD) subjects under hemodialysis and in kidney transplantation(KT) recipients, being an important cause of morbidity and mortality in these patients. The vast majority of HCV chronic infections in the hemodialysis setting are currently attributable to nosocomial transmission. Acute and chronic hepatitis C exhibits distinct clinical and laboratorial features, which can impact on managementand treatment decisions. In hemodialysis subjects, acute infections are usually asymptomatic and anicteric; since spontaneous viral clearance is very uncommon in this context, acute infections should be treated as soon as possible. In KT recipients, the occurrence of acute hepatitis C can have a more severe course, with a rapid progression of liver fibrosis. In these patients, it is recommended to use pegylated interferon(PEG-IFN) in combination with ribavirin, with doses adjusted according to estimated glomerular filtration rate. There is no evidence suggesting that chronic hepatitis C exhibits a more aggressive course in CKD subjects under conservative management. In these subjects, indication of treatment with PEG-IFN plus ribavirin relies on the CKD stage, rate of progression of renal dysfunction and the possibility of a preemptive transplant. HCV infection has been associated with both liver disease-related deaths and cardiovascular mortality in hemodialysis patients. Among those individuals, low HCV viral loads and the phenomenon of intermittent HCV viremia are often observed, and sequential HCV RNA monitoring is needed. Despite the poor tolerability and suboptimal efficacy of antiviral therapy in CKD patients, many patients can achieve sustained virological response, which improve patient and graft outcomes. Hepatitis C eradication before KT theoretically improves survival and reduces the occurrence of chronic graft nephropathy, de novo glomerulonephritis and post-transplant diabetes mellitus. | Roberto J Carvalho-Filho Ana Cristina CA Feldner Antonio Eduardo B Silva Maria Lucia G Ferraz | 2015 | World Journal of Gastroenterology2015，21，2： | 4 |
| 3 | Central nervous system vasculitis and polyneuropathy as first manifestations of hepatitis C显示文摘Sensory or motor peripheral neuropathy may be observed in a significant proportion of hepatitis C virus (HCV)-infected patients.However,central nervous system (CNS) involvement is uncommon,especially in cryoglobulin-negative subjects.We describe a case of peripheral neuropathy combined with an ischemic CNS event as primary manifestations of chronic HCV infection without cryoglobulinemia.Significant improvement was observed after antiviral therapy.We discuss the spectrum of neurological manifestations of HCV infection and review the literature. | Roberto J Carvalho-Filho Janaína Luz Narciso-Schiavon Luciano HL Tolentino Leonardo L Schiavon Maria Lucia G Ferraz Antonio Eduardo B Silva | 2012 | World Journal of Gastroenterology2012，18，2： | 3 |
| 4 | Six-minute walking test performance is associated with survival in cirrhotic patients显示文摘BACKGROUND Patients with cirrhosis are at risk of cirrhotic cardiomyopathy,with resulting cardiac dysfunction and exercise limitations.Six minute walking test(6MWT)assesses functional status and predicts morbidity and mortality in cardiopulmonary diseases.AIM To determine if it associates with mortality by analyzing 6MWT performance in patients with liver cirrhosis.METHODS A cohort of 106 cirrhotic patients was evaluated in the outpatient setting with echocardiogram and 6MWT and follow up for one year to document hepatic decompensation and mortality.The distance in meters was recorded at the end of 6 min(6MWD).RESULTS This cohort had a mean age of 51 years and 56%male;patients were staged as Child A in 21.7%,B 66%and C 12.3%.Walk distance inversely correlated with Child scores,and was significantly reduced as Child stages progresses.Patients who died(10.4%)showed shorter mean 6MWD(P=0.006).Low 6MWD was an independent predictor of mortality(P=0.01).CONCLUSION 6MWT is a noninvasive inexpensive test whose result is related to Child scores and mortality.It is useful to identify patients with liver cirrhosis at high risk of mortality for closer monitoring and potential early intervention. | Carolina Frade M G Pimentel Ana Cristina de Castro Amaral Adriano Miziara Gonzalez Michelle Lai Danielde Oliveira Mota Maria Lucia Gomes Ferraz Wilson Mathias Junior Mario Kondo | 2021 | World Journal of Hepatology2021，13，11： | 2 |
| 5 | Interhospitaltransfer of pan-resistant Acinetobacter strains in Johannesburg,South Africa显示文摘 | MARAIS E DE JONG G FERRAZ V | 2004 | Am J Infect Control2004，32，5： | 1 |
| 6 | TL, EPR and optical absorption studies on natural alexandrite compared to natural chrysoberyl 显示文摘 | Ferraz G M Watanabe S Souza S O | 2002 | Radiation Protection Dosimetry2002，100，14： | 1 |
| 7 | Photoelectrocatalysis based on Ti/TiO2 nanotubes removes toxic properties of the azo dyes Disperse Red 1, Disperse Red 13 and Disperse Orange 1 from aqueous chloride samples 显示文摘 | Ferraz E R A Oliveira G A R Grando M D | 2013 | J Environ Manage2013，124，： | 1 |
| 8 | Name Reactions for Carbocyclic Ring Formations 显示文摘 | FERRAZ H M C BIANCO G G TEIXEIRA C | 2007 | Tetrahedron Asymmetry2007，18，12： | 1 |
| 9 | Amin- ophylline affects glycemia control and increases anaerobic gly- colysis in horses during incremental exercise显示文摘 | Ferraz G C Teixeira-Neto A R Lacerda-Neto J C etal | 2008 | Journal of E- quine Veterinary Science2008，28，7： | 1 |
| 10 | Hydrogen sul- fide : an endogenous mediator of resolution of inflamma- tion and injury 显示文摘 | Wallace J L Ferraz J G Muscara M N | 2012 | Antioxid Redox Signal2012，17，1： | 1 |
| 11 | Static and dynamic analysis of theanterior segment with optical coherence tomography 显示文摘 | Baikoff G Lutun E Ferraz C | 2004 | J Cata-ract Refract Surg2004，30，： | 1 |
| 12 | Static and dynamic analysis of the anterior segment with optical coherence tomography显示文摘 | Baikoff G Lutun E Ferraz C | 2004 | J Cata- ract Refract Surg2004，30，： | 1 |
| 13 | Xanthine Oxidase Inhibitory Activity of Lychnophora Species From Brazil (' Arnica') 显示文摘 | FERRAZ FILLHA Z S VITOLO I F FIETTO L G | 2006 | Journal of Ethno- pharmacology2006，，107： | 1 |
| 14 | Specific immunoassays for endocrine disruptor monitoring using recombinant antigens cloned by degenerated primer PCR 显示文摘 | Ferraz N Carnevia D Nande G | 2007 | Analytical and Bioanalytical Chemistry2007，389，78： | 1 |
| 15 | Static and dynamic analysis of the anterior segment with optical coherence tomography显示文摘 | Baikoff G Lutun E Ferraz C | 2004 | J Cata- ract Refract Surg2004，30，： | 1 |
| 16 | En- hancement of cellulose hydrolysis in sugarcane bagasse by the selective removal of lignin with sodium chlorite 显示文摘 | G Siqueira A V6rnai A Ferraz A M F Milagres | 2013 | Applied Energy2013，102，0： | 1 |
| 17 | A literature review ofeyelodextrin inclusion complexes characterization-Part I:Phase solubilitydiagram, dissolution and scanning electron microscopy 显示文摘 | Takahashi A I Veiga F J B Ferraz H G | 2012 | International Journal of Pharmaceutical Sciences Review and Research2012，12，1： | 1 |
| 18 | Lack of Evidence of Upper Gastrointestinal Endoscopy as a Risk Factor for Transmission of Hepatitis B Virus 「letter」显示文摘 | Ferrari A P Geocze S Ferraz M L G | 1991 | Endoscopy1991，23，： | 1 |
| 19 | Static and dynamic analysis of theanterior segment with optical coherence tomography 显示文摘 | Baikoff G Lutun E Ferraz C | 2004 | J Cata-ract Refract Surg2004，30，： | 1 |
| 20 | A naturally occurring deletion in the SRY promoter region affecting the Sp1 binding site is associated with sex reversal显示文摘 | Assumpcao J G Ferraz L F Benedetti C E | 2005 | J Endocrinol Invest2005，28，7： | 1 |
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