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| 1 | Management of hepatitis C in patients with chronic kidney disease显示文摘Hepatitis C virus(HCV) infection is highly prevalent among chronic kidney disease(CKD) subjects under hemodialysis and in kidney transplantation(KT) recipients, being an important cause of morbidity and mortality in these patients. The vast majority of HCV chronic infections in the hemodialysis setting are currently attributable to nosocomial transmission. Acute and chronic hepatitis C exhibits distinct clinical and laboratorial features, which can impact on managementand treatment decisions. In hemodialysis subjects, acute infections are usually asymptomatic and anicteric; since spontaneous viral clearance is very uncommon in this context, acute infections should be treated as soon as possible. In KT recipients, the occurrence of acute hepatitis C can have a more severe course, with a rapid progression of liver fibrosis. In these patients, it is recommended to use pegylated interferon(PEG-IFN) in combination with ribavirin, with doses adjusted according to estimated glomerular filtration rate. There is no evidence suggesting that chronic hepatitis C exhibits a more aggressive course in CKD subjects under conservative management. In these subjects, indication of treatment with PEG-IFN plus ribavirin relies on the CKD stage, rate of progression of renal dysfunction and the possibility of a preemptive transplant. HCV infection has been associated with both liver disease-related deaths and cardiovascular mortality in hemodialysis patients. Among those individuals, low HCV viral loads and the phenomenon of intermittent HCV viremia are often observed, and sequential HCV RNA monitoring is needed. Despite the poor tolerability and suboptimal efficacy of antiviral therapy in CKD patients, many patients can achieve sustained virological response, which improve patient and graft outcomes. Hepatitis C eradication before KT theoretically improves survival and reduces the occurrence of chronic graft nephropathy, de novo glomerulonephritis and post-transplant diabetes mellitus. | Roberto J Carvalho-Filho Ana Cristina CA Feldner Antonio Eduardo B Silva Maria Lucia G Ferraz | 2015 | World Journal of Gastroenterology2015，21，2： | 4 |
| 2 | Central nervous system vasculitis and polyneuropathy as first manifestations of hepatitis C显示文摘Sensory or motor peripheral neuropathy may be observed in a significant proportion of hepatitis C virus (HCV)-infected patients.However,central nervous system (CNS) involvement is uncommon,especially in cryoglobulin-negative subjects.We describe a case of peripheral neuropathy combined with an ischemic CNS event as primary manifestations of chronic HCV infection without cryoglobulinemia.Significant improvement was observed after antiviral therapy.We discuss the spectrum of neurological manifestations of HCV infection and review the literature. | Roberto J Carvalho-Filho Janaína Luz Narciso-Schiavon Luciano HL Tolentino Leonardo L Schiavon Maria Lucia G Ferraz Antonio Eduardo B Silva | 2012 | World Journal of Gastroenterology2012，18，2： | 3 |
| 3 | Physical characterization of hydroxyapatite porous scaffolds for tissue engineering 显示文摘 | Teixeira S Rodriguez M A Pena P De Aza A H De Aza S Ferraz M P Monteiro F J | 2009 | Materials Science & Engineering C-Biomimetic and Supramolecular Systems2009，29，5： | 1 |
| 4 | Amin- ophylline affects glycemia control and increases anaerobic gly- colysis in horses during incremental exercise显示文摘 | Ferraz G C Teixeira-Neto A R Lacerda-Neto J C etal | 2008 | Journal of E- quine Veterinary Science2008，28，7： | 1 |
| 5 | Hydrogen sul- fide : an endogenous mediator of resolution of inflamma- tion and injury 显示文摘 | Wallace J L Ferraz J G Muscara M N | 2012 | Antioxid Redox Signal2012，17，1： | 1 |
| 6 | Emergy assessment of integrated production systems of grains, pig and fish in small farms in the South Brazil显示文摘 | Otávio Cavalett Júlio Ferraz de Queiroz Enrique Ortega | 2005 | Ecological Modelling2005，，3： | 1 |
| 7 | Chronic sub- dural hematoma: epidemiological and prognostic analysis of 176 cases显示文摘 | Farhat Neto J Araujo JL Ferraz VR | 2015 | Rev Col Bras Cir2015，42，5： | 1 |
| 8 | Liver transplant for the treatment of giant hepatic hemangioma 显示文摘 | Ferraz AA Sette M J Maia M | 2004 | Liver Transpl2004，10，11： | 1 |
| 9 | The Kauffman model on smallworld topology显示文摘 | Ferraz C H A Herrmann H J | 2006 | Physica A:Statistical Mechanics and its Applications In Press Corrected Proof2006，17，： | 1 |
| 10 | The azo dyes DisperseRed 1 and Disperse Orange 1 increase the micronuclei frequenciesin human lymphocytes and in HepG2 cells 显示文摘 | Chequer F M Angeli J P Ferraz E R | 2009 | Mutation Research2009，676，12： | 1 |
| 11 | CaO-P2O5 glass hydroxyapatite double-layer plasma-sprayed coating:in vitro bioactivity evaluation显示文摘 | Ferraz M P Monteiro F J Santos J D | 1999 | J Biomed Mater Res1999，45，： | 1 |
| 12 | Effect of chemical composition on hydrophobicity and zeta potential of plasma sprayed HA/CaO-P2O5 glass coatings显示文摘 | Ferraz M P Monteiro F J Serro A P | 2001 | Biomaterials2001，22，： | 1 |
| 13 | Nanohydroxyapatite Microspheres as Delivery System for Antibiotics:Release Kinetics,Antimicrobial Activity,and Interaction with Osteoblasts显示文摘 | Ferraz M P Mateus A Y Sousa J C | 2007 | Wiley InterScience2007，81，4： | 1 |
| 14 | A conservation GAP analysis of Brazil Amazonian vegetation显示文摘 | Fearnside P M J Ferraz | 1995 | Conservation Biology1995，9，： | 1 |
| 15 | Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy 显示文摘 | LECOMTE T FERRAZ J M ZINZINDOHOUE F | 2004 | Clin Cancer Res2004，10，17： | 1 |
| 16 | Identification and characterization of polymorphisms within the 5'flanking region,first exon and part of first intron of bovine GH gene显示文摘 | Ferraz A L Bortolossi J C Curi R A | 2006 | J Anim Breed Genet2006，123，3： | 1 |
| 17 | McCune-Albright syndrome and acromegaly:hormonal control with use of cabergoline and long-acting somatostatin--case report显示文摘 | Almeida J P Albuquerque L A Ferraz C L | 2009 | Arq Bras Endocrinol Metabol2009，53，1： | 1 |
| 18 | Animal model estimation of genetic parameters and response to selection for litter size and weight,growth,and backfat in closed seedstock populations of large white and landrace swine显示文摘 | FERRAZ J B JOHNSON R K | 1993 | J Anim Sci1993，71，4： | 1 |
| 19 | CaO-P205 Glass- Hydroxyapatite Thin films Obtained by Laser Ablation: Characterization and in Vitro Bioactivity 显示文摘 | Ferraz M P Monteiro F J Giao D | 2004 | Key Eng Mater2004，，： | 1 |
| 20 | The azo dyes disperse red 1 ant disperse orange increase the micronuclei frequen cies in human lymphocytes and in HepG2 cells显示文摘 | CHEQUER F M D ANGELI J P F FERRAZ E R A | 2009 | Mutation ResearchGenetic Toxicology and Environmental Mutagenesis2009，676，1： | 1 |
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